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The mitochondrial intermembrane space nuclease Nuc1 (endonuclease G) prevents mitophagy-mediated mtDNA escape in yeast
Cupo et al. find that Nuc1 nuclease activity and mitochondrial intermembrane space
localization prevent mtDNA escape in yeast. In Nuc1 mutants, inducing mitophagy increases
mtDNA escape, whereas inhib...