Building on their landmark efforts to create cell-type atlases of adult brains using single-cell and spatial genomics technologies, researchers in the BRAIN ...

A team of researchers at Penn State College of Medicine and the Allen Institute for Brain Science has produced 3D growth charts with resolution high enough to differentiate between cell types in the d...

The developmental dynamics of distinct cell types across brain regions remain poorly understood. Here authors generate DevAtlas, a high-resolution developmental 3D atlas, mapping region and cell type-...

The portrayal of uncaring scientists without any thought for the animals being used in their research is far from the truth.

Postdoc for an NIH SSPsyGene consortium project to uncover novel insights into the genetic and molecular underpinnings of neurodevelopmental disorders

A lipid-nanoparticle-based formulation incorporating engineered lipids containing a blood–brain-barrier-crossing moiety effectively delivers mRNA to neurons and astrocytes following systemic administr...

Scientists rally across the country in response to layoffs and funding cuts ordered by the Trump administration

White matter (WM) astrocytes differ significantly from gray matter astrocytes, with WM astrocytes in the forebrain exhibiting unique proliferation capacity, which is absent in cerebellar WM, suggestin...

Illuminating key biological pathways that underlie neurodevelopmental and psychiatric disorders, such as autism spectrum disorder and attention deficit hyperactivity disorder, is the goal of a new fiv...

PennState Hershey Medical Center

The main interest of the Kim lab is to understand the cellular architecture of the nervous system and how it supports cognitive functions in the mammalian brain. We use mice as our main animal model. The unique challenge to understanding the governing principles of the mammalian brain is that microscopic structures (e.g., cell bodies, axons) interact with each other in a macroscopic network (e.g., whole brain) to generate behavior. To overcome this challenge, we develop and utilize high-resolution 3D brain mapping methods to examine cellular details in the entire mouse brain. Leveraging our novel methods, we focus on three discreet, yet inter-related research topics.