Sign in

Yizhou Hu(Eugene)

@yizhoueugene.bsky.social
54 followers 115 following 18 posts

Researcher;System Medicine,developmental plasticity in nervous system cancers, psoriatic skin ;@Karolinska Inst. , @Wihuri Inst. & Univ. of Helsinki

PostsRepliesMedia
Reposted by Yizhou Hu(Eugene)
Ted Price @tedpricethepainguy.bsky.social · 10/03/2026
BOOM! Fantastic new paper from Patrik Ernfors and his team: www.nature.com/articles/s41... Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis
nature.com
Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis - Nature Neuroscience
Su et al. show that inflammatory arthritis pain stems from sustained interferon-driven MNK1/MNK2–elF4E signaling that sensitizes joint-innervating neurons. Blocking this pathway reverses pain, suggest...
12211
Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 05/03/2026
Huge congratulations to @patrikernfors.bsky.social ! Truly well-deserved honor!🎉🎉🎉
020
Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 29/01/2026
Everything can be modeled. In the future, knowledge will cost mere kilowatt hours, and discovery , somehow, will be the calibration of new data embeddings.
000
Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 06/11/2025
Huge congratulations, Sara! Dream Team!🎉🎉🎉
110
Reposted by Yizhou Hu(Eugene)
Gonçalo Castelo-Branco @gocastelobranco.bsky.social · 05/11/2025
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com www.nature.com/articles/s41...
nature.com
Spatial dynamics of brain development and neuroinflammation - Nature
A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.
58026
Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 05/11/2025
Big congrats, Gonçalo!🎉🎉
010
Reposted by Yizhou Hu(Eugene)
bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 21/09/2025
GUANACO: A Unified Web-Based Platform for Single-Cell Multi-Omics Data Visualization www.biorxiv.org/content/10.1101/202…
001
Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 22/09/2025
Thrilled to collaborate on cosupervising this work! GUANACO puts single-cell MultiOmics visualization in reach for bench scientists: built-in stats, no code for publication-ready figures. pls explore more functions from the link 👇Congrats to the team!
000
Reposted by Yizhou Hu(Eugene)
Mattia Zaghi @matzag.bsky.social · 10/09/2025
A few weeks ago, I had to discuss about DynaTag, a smart tweak to CUT&Tag that enables single-cell transcription factor mapping with just a buffer change. Opening a number of future avenues. 📰 Via @GenomeWeb : lnkd.in/djYm_sGg #epigenetics #singlecell
lnkd.in
LinkedIn
This link will take you to a page that’s not on LinkedIn
0135
Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 10/09/2025
Our study on neuroblastoma developmental plasticity is the cover story in the latest issue of Dev. Cell @cp-devcell.bsky.social .The Chinese-ink Taiji (Yin–Yang) cover to echo cell-state transitions. Huge thanks to the editors, co-authors. #Neuroblastoma www.cell.com/developmenta...
031
Reposted by Yizhou Hu(Eugene)
François Lallemend @flallemend.bsky.social · 02/06/2025
Postdoc in Computational Biology – Auditory Pathways & Sensory Disorders @LallemendLab to study how peripheral/central auditory pathways (circuit, cellular, molecular) are altered in tinnitus & age-related hearing loss. #scRNAseq, #barcode-lineage-tracing, #translational ki.varbi.com/what:job/job...
ki.varbi.com
Postdoctoral studies in single-cell and computational biology
Postdoctoral studies in single-cell and computational biology Do you want to contribute to top quality medical research?  A postdoctoral position is available in the laboratory of Professor Francois
033
Reposted by Yizhou Hu(Eugene)
Jens Hjerling Leffler @hjerling-leffler.bsky.social · 02/06/2025
Postdoc positions available in my lab @ki.se Sweden - exciting science, fantastic environment and great quality of life. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. ki.varbi.com/en/what:job/...
ki.varbi.com
Postdoc in Single Cell Genomics, Jens Hjerling-Leffler group, Karolinska Institutet
Do you want to contribute to top quality medical research? The position is located within The Division of Molecular Neurobiology in the lab of Professor Jens Hjerling-Leffler at the Department of Medi
01814
Reposted by Yizhou Hu(Eugene)
UlrikaKMarklund @ulrikakmarklund.bsky.social · 29/05/2025
Check out our new study on the innermost nervous system of the body—the submucosal plexus. We define three neuronal classes, map their connectivity, and uncover their stepwise development via phenotypic switching. Congrats to all authors! #NatureNeuroscience #EntericNervousSystem rdcu.be/eoqXz
rdcu.be
The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine
Nature Neuroscience - The neuronal composition of the intestinal submucosal plexus is incompletely understood. Here Li et al. define their neuron classes, connectome and stepwise acquisition of...
1166
Reposted by Yizhou Hu(Eugene)
Igor Adameyko @adameykolab.bsky.social · 20/05/2025
If you want to run MERFISH spatial transcriptomics and you search for the optimized probe codebooks, here they are: www.science.org/doi/10.1126/...
science.org
Boosting multiplexing capabilities for error-robust spatial transcriptomic methods using a set exchange approach
Using an algorithm, highly optimized error-robust codebooks for spatial transcriptomic methods can systematically be produced.
0186
Reposted by Yizhou Hu(Eugene)
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · 12/05/2025
🎫 Exclusive event: One-day symposium on #Brain #Tumor #Plasticity 🕣September 16, 2025. The Royal Swedish Academy of Sciences, Stockholm @scienceacademyswe.bsky.social Few spots available. Register here: ui.ungpd.com/Events/ed387...
ui.ungpd.com
Brain Tumor Plasticity
A growing body of evidence emphasizes the presence of significant intra-tumoral phenotypic diversity and plasticity within brain tumors. Inherent plasticity introduces an additional layer of intricacy...
166
Reposted by Yizhou Hu(Eugene)
Marek Bartosovic @mardzix.bsky.social · 07/05/2025
Epichrom 2025 ! After 3 years, Epichrom is revived and will take place in Stockholm on the 12th of June. Great opportunity to share your research and hear about latest epigenetics/chromatin research in Sweden. Registration is free of charge www.bartosovic-lab.com/epichrom
lnkd.in
LinkedIn
This link will take you to a page that’s not on LinkedIn
154
Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 12/05/2025
Thank you @ki.se for sharing our @cp-devcell.bsky.social study on neuroblastoma developmental plasticity! 🙏🚀
010
Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 10/05/2025
Thank you, Susanne! Your help made this possible.
000
Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 09/05/2025
9/9🙏 Thanks to our collaborators: @schlisio-lab.bsky.social , Prof. Arthur Tischler (@tuftsmedicalcenter.bsky.social), Prof. Ronald de Krijger ( @themaximacenter.bsky.social ), and all the other amazing team members!
020
Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 09/05/2025
8/9 Our enhanced neural-network tool, scCAMEL, now aligns cross-species, multimodal data in a single workflow—empowering comprehensive mapping of tumor plasticity. sccamel.readthedocs.io/en/latest/
sccamel.readthedocs.io
scCAMEL — scCAMEL 0.26b documentation
100
Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 09/05/2025
7/9 Spatial maps reveal clonal pockets of bridge & neural‑crest‑like cells encircled by TAMs & CAFs that sustain aggressiveness—micro‑environment is a Dev. state‑specific partner‑in‑crime.
100
Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 09/05/2025
6/9 Functional hits 👉 E2F7-networks fuel de‑differentiation, while HMX1 can force differentiation—unless MYCN amplification blocks it.---> Dev. state‑specific vulnerabilities = therapeutic targets.
100
Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 09/05/2025
5/9 🔑 Enhancer–gene regulatory networks uncover 121 core TF gene patterns organized into five principal patterns: Cell Cycle, ADRN-meta, ADRN-neu, Mes-Prog, and Mes-immune.
110
Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 09/05/2025
4/9 The enhancer‑primed epigenetic landscape gives neuroblastoma cells the "latent" capacity to shift between developmental programs.
100
Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 09/05/2025
3/9 We traced 7 NBL cell states back to the trunk neural crest lineage. A previously less-appreciated “bridge” state acts as the hub for state switching and, together with neural‑crest‑like cells, dominates high‑risk NBL.
100
Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 09/05/2025
2/9 In collaboration with @patrikernfors.bsky.social and Jian Wang’s team, we integrated single-cell and spatial transcriptomics from patient tumors and scRNA+ATAC data from mouse spontaneous models to construct a high-resolution disease atlas.
100
Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 09/05/2025
1/9 🚀 Our latest findings in @cp-devcell.bsky.social : #Neuroblastoma cells aren’t locked into one single fate—they flip between developmental programs, driving tumor heterogeneity and malignancy. www.sciencedirect.com/science/arti...
sciencedirect.com
Single-cell MultiOmics and spatial transcriptomics demonstrate neuroblastoma developmental plasticity
Neuroblastoma, the most prevalent extracranial pediatric solid tumor, arises from neural crest progeny cells. It exhibits substantial developmental pl…
2126
Reposted by Yizhou Hu(Eugene)
Gonçalo Castelo-Branco @gocastelobranco.bsky.social · 05/05/2025
Join us at the Nobel Symposium Multiple Sclerosis: Past, Present and Future Treatment June 5th, 2025 | Jacob Berzelius lecture hall @ki.se | Stockholm, Sweden free registration at: jirango.com/cview/web/f0...
1145
Reposted by Yizhou Hu(Eugene)
Patrik Ernfors @patrikernfors.bsky.social · 24/03/2025
How is the input of the different kinds of primary sensory neurons responding to heat and mechanical stimuli summarized in the spinal cord? Check out our recent study. www.nature.com/articles/s41...
nature.com
Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord - Nature Neuroscience
Zhang et al. identify unimodal neural representations in the spinal cord of cutaneous mechanical and heat stimuli gated by a shared feed-forward local inhibitory neuron type and a neural transition du...
05325
Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 13/03/2025
New mug, #science_doesn’t_care_what_U_believe
000