npj Drug Discovery - Intracellular GPCR modulators enable precision pharmacology

Insight – a sudden change in understanding or perspective that feels true or reliable – is a common occurrence during psychedelic experiences, and oft…

The development of macrocyclic binders to therapeutic proteins typically relies on large-scale screening methods that are resource-intensive and provide little control over binding mode. Despite consi...

Abstract. Pharmacogenomics, the study of how an individual's genetic makeup influences their response to medications, is a rapidly evolving field with sign

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Akuammicine (1), an alkaloid isolated from Picralima nitida, is an agonist of the kappa opioid receptor (κOR). To establish structure–activity relationships (SARs) for this structurally unique κOR lig...