Sign in

Daniel Wrapp

@wrapplab.bsky.social
318 followers 77 following 1 posts

Host-pathogen interactions, structural biology, protein design and more. Assistant Professor at Duke University. www.wrapplab.org

PostsRepliesMedia
Reposted by Daniel Wrapp
Laboratory of Functional Viromics (LETKO) @fviromics.bsky.social · 16/09/2026
Our hedgehog coronavirus receptor study is now out in Nature Microbiology! Exciting new data has been added since the pre-print, including structure-guided mutagenesis showing species barriers, TMPRSS2 experiments and more details on the curious temperature adaptation in hedgehogs. (1/4)
184
Reposted by Daniel Wrapp
American Society for Virology @amersocvirology.bsky.social · 09/06/2026
ASV is alarmed by the US HHS to suspend and debar Dr. Ralph Baric from federal funding. Read our open letter below:
Open letter from ASV to protest US HHS actions against Dr. Ralph Baric.
04435
Reposted by Daniel Wrapp
Jon Cohen @cohenjon.bsky.social · 12/05/2026
www.science.org/content/arti...
science.org
Virologist accused of starting COVID-19 will fight U.S. ban on funding
HHS memo says Ralph Baric had a “pattern of deception” in describing virus studies long before pandemic
01912
Reposted by Daniel Wrapp
Cell - a Cell Press journal @cp-cell.bsky.social · 27/02/2026
Now online! High-resolution in situ structures of hantavirus glycoprotein tetramers
dlvr.it
High-resolution in situ structures of hantavirus glycoprotein tetramers
The cryo-EM structures of Andes hantavirus (ANDV) glycoprotein tetramers, dimers of tetramers, and ADI-65534 Fab complexes on eVLPs unveil the molecular basis of New World hantavirus glycoprotein architecture, acid-induced membrane fusion, and antibody-mediated neutralization. Immunization with repRNA encoding ANDV-VLPs elicits high neutralizing-antibody titers.
085
Reposted by Daniel Wrapp
Mera L🪬 @mlicc1701.bsky.social · 10/01/2026
It's really real 😭😭😭 Huge thanks to Wrapper's Delight ( @wrapplab.bsky.social ) and T-Pain ( @timothysheahan.bsky.social ) for everything. Working on this together was the best part of 2025!
174
Reposted by Daniel Wrapp
Tim Sheahan @timothysheahan.bsky.social · 10/01/2026
Human coronavirus 229E antibodies and Spike structure function paper is finally out for real. Led by @wrapplab.bsky.social (wrappers delight) and @mlicc1701.bsky.social (MFL) #lovevirology #229E #antibodies www.nature.com/articles/s42...
nature.com
Client Challenge
1103
Reposted by Daniel Wrapp
Communications Biology @commsbio.nature.com · 09/01/2026
A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain www.nature.com/articles/s42... @wrapplab.bsky.social
032
Reposted by Daniel Wrapp
Matt Slein @mattslein.bsky.social · 19/11/2025
Excited to share a new publication from my PhD labs where we explore a method to improve antibody-mediated protection against herpes simplex virus infections: www.science.org/doi/10.1126/...
science.org
Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice
HSV-specific antibodies demonstrate improved activity in vitro and in vivo when the IgG Fc domain is rendered insensitive to the viral Fc receptor.
063
Reposted by Daniel Wrapp
Jason McLellan @mclellanlab.bsky.social · 08/10/2025
I'm honored to receive a MacArthur Fellowship. As always, I extend my sincerest thanks to all my wonderful mentors, colleagues, collaborators, admins, and trainees who make this work possible. #MacFellow
3222034
Reposted by Daniel Wrapp
@WashUCVIMP.bsky.social @washucvimp.bsky.social · 02/09/2025
As part of our 2025 “Rising Stars in #Vaccinology and #Immunity to #Microbes” seminar series, we spoke with Dr. Daniel Wrapp @wrapplab.bsky.social who uses structure-based design to develop new #antiviral therapies. cvimp.podbean.com/e/episode-13...
cvimp.podbean.com
Episode 13: Using structure-based design to develop novel antiviral therapeutics | Creating Memory: Vaccines & Immunity
We talk with Dr. Daniel Wrapp, Assistant Professor Assistant Professor at the Duke Human Vaccine Institute at Duke University School of Medicine, NC, who uses structure-based design to develop novel t...
0167
Reposted by Daniel Wrapp
Jason McLellan @mclellanlab.bsky.social · 18/06/2025
Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
27926
Reposted by Daniel Wrapp
cryoEM papers @cryoempapers.bsky.social · 20/05/2025
Design, Structure, and Immunogenicity of a Soluble Prefusion-stabilized EBV gB Antigen www.biorxiv.org/content/10.1101/2025.05.19.654955v1 #cryoEM
055
Daniel Wrapp @wrapplab.bsky.social · 19/05/2025
Very excited to share our latest preprint describing the isolation and characterization of neutralizing HCoV-229E-directed antibodies from a human donor! Great collaboration between DHVI and the Baric and Sheahan (@timothysheahan.bsky.social) labs at UNC. www.biorxiv.org/content/10.1...
biorxiv.org
A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain
HCoV-229E is an endemic Alphacoronavirus that typically causes common cold-like disease in most healthy adults, but can also cause severe respiratory disease in the very young and the elderly. Althoug...
11811