Helicase-driven copy-back RNA synthesis in coronaviruses reveals how antivirals trap replication intermediates.

HHS memo says Ralph Baric had a “pattern of deception” in describing virus studies long before pandemic

Baric’s life’s work paved the way for vaccines against COVID-19. But it brought scrutiny to him, his lab, and UNC in the process.

Coronaviruses (CoV) are important human pathogens causing hundreds of millions of infections and millions of deaths over the past 20 years. The study of how these viruses multiply and cause disease id...

Days Hours Minutes Seconds Program Registration Abstracts Organizing Committee Social Events Welcome to HCV-Flavi 2026 We warmly invite you to join the 32nd International Symposium on Hepatitis C Viru...

A new paper shows that women, particularly those early in their careers, have been disproportionately affected by NIH grant terminations.

Coronaviruses (CoVs) replicate their RNA genomes with increased fidelity than other RNA viruses, a mechanism mediated by the proofreading and recombination activities of the exoribonuclease domain of ...

To best combat the evolving landscape of SARS-CoV-2 variants of interest and variants of concern, the development of effective small animal models is of critical importance. Herein, we describe the de...

This work shows that receptor use in merbecovirus is clade-specific by clustering them into clades based on the receptor-binding domain (RBD) of their spike proteins. While MERS-CoV and its close rela...

Researchers calculated that $1.8 billion in National Institutes of Health grants were terminated in just over one month

Move by US biomedical agency threatens thousands of projects on infectious diseases, cancer and more.

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Rescission of the Final Scientific Integrity Policy of the National Institutes of Health NOT-OD-25-080. OD

Federal officials cited the end of the Covid-19 pandemic in halting the research. But much of the work was focused on preventing outbreaks of other pathogens.

NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...

Emerging coronaviruses like SARS-CoV, SARS-CoV-2, and MERS-CoV cause a range of disease outcomes in humans from an asymptomatic, moderate, and severe respiratory disease that can progress to death but...

Researchers facing

Aaron Siri, who specializes in vaccine lawsuits, has been at Robert F. Kennedy Jr.’s side reviewing candidates for top jobs at the Department of Health and Human Services.

Zhou et al. describe NZ-804, a non-peptidic inhibitor of the SARS-CoV-2 Mpro. It shows potent antiviral activity with low-nanomolar IC50 and EC50 in human lung cells and primary airway epithelial cult...