Grinat et al. identify IRS2 as a central regulator of placental syncytiotrophoblast differentiation. Using mouse genetics, CRISPR-engineered trophoblast stem cells, and human trophoblast stem cells an...

Un equipo del Centro de Biología Molecular Severo Ochoa (CBM), instituto mixto del Consejo Superior de Investigaciones Científicas (CSIC) y la Universidad Autónoma de Madrid (UAM), ha identificado en ...

Un equipo liderado desde el Centro de Biología Molecular Severo Ochoa del Consejo Superior de Investigaciones Científicas (CBM-CSIC-UAM) ha desarrollado organoides de oviducto bovino, pequeñas estruct...

Cellular and Molecular Life Sciences - The oviduct provides the dynamic microenvironment that supports fertilization and early embryo development yet replicating its hormonally regulated secretory...

Un equipo internacional de investigadores liderados desde el Centro de Biología Molecular Severo Ochoa, centro mixto del CSIC y la UAM, ha identificado un mecanismo molecular implicado en la preeclamp...

Cell Death & Disease - BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia

Building an in vitro model of receptive endometrium allows investigation of human embryo implantation and early post-implantation development and recapitulates the earliest stages in establishing the ...

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Preeclampsia, a life-threatening hypertensive disorder of pregnancy, is a leading cause of maternal and perinatal morbidity and mortality. Its early-onset form (EO-PE), requiring delivery before 34 we...

European Research Council president describes scheme as part attempt to lure US talent

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The benefit of beta-blockers after myocardial infarction in patients with a preserved left ventricular ejection fraction (LVEF) is unclear. We conducted a meta-analysis at the individual-patient le...

Summary: This Review contains an overview of placental vascular development and pathologies in mice and humans and highlights key remaining questions in the field.

Michita et al. show that Zika virus (ZIKV) NS1 induces tunneling nanotubes (TNTs) in placental cells, which facilitate viral spread and transport of mitochondria in placental cells. Infection with a NS1 mutant ZIKV not inducing TNTs results in a higher interferon response than wild-type ZIKV infection.

La expresión de los genes es el proceso mediante el cual la información contenida en el material genético se utiliza para producir proteínas, que a su vez realizan una función […]

The placental DNA methylation landscape is unique, with widespread partially methylated domains (PMDs). The placental “methylome” is conserved across …

The glycosylphosphatidylinositol (GPI) biosynthetic pathway in the endoplasmic reticulum (ER) is crucial for generating GPI-anchored proteins (GPI-APs), which are translocated to the cell surface and ...