Victoria Hart @vichart33.bsky.social · 30/04/2026Another brilliant Sheffield Pancreatic Cancer Research Network meeting. We heard two fantastic researchers working at the cutting edge of PC. Samrein Ahmed (SHU) shared mechanistic insights into RLIP76, and Helen Matthews (UoS) explored adhesion-dependent resistance to KRAS inhibition. 032
Victoria Hart @vichart33.bsky.social · 23/03/2026Interested in Pancreatic Cancer Research? We'll be hosting our 8th Sheffield Pancreatic Cancer Research Network meeting in April! Check out the details at: sites.google.com/sheffield.ac... @mcb-sheffield.bsky.social @fohsheffield.bsky.socialsites.google.com 000
Reposted by Victoria HartHelen Matthews @helenkmatthews.bsky.social · 18/12/2025How does Ras signalling affect actin? Some answers in a new review from Joe Tyler & I @mcb-sheffield.bsky.social authors.elsevier.com/a/1m8v-3PA3s... We discuss how Ras proteins coordinate local and global changes to the actin cytoskeleton and contribute to cytoskeletal plasticity in cancer. 0185
Victoria Hart @vichart33.bsky.social · 20/11/2025On World Pancreatic Cancer Day, the Sheffield Pancreatic Cancer Interest Network hosted a successful bake sale to raise funds and awareness for PCUK. Thank you to all who participated and supported our efforts. #WorldPancreaticCancerDay 011
Victoria Hart @vichart33.bsky.social · 22/10/2025Another fantastic set of talks at the 7th Sheffield Pancreatic Cancer Research Interest Network. A big thank you to Stephen Bradley and Ifeoluwa Oyelade for sharing their inspiring research. #PancreaticCancer #CancerResearch 001
Victoria Hart @vichart33.bsky.social · 13/10/2025A beautiful and inspiring location for the #TargetingRAS2025 conference. The pace of discovery in the field is truly astounding. It was such a pleasure to share ideas and meet some great people. #Salamanca #RAS #Biology #CancerBiology 020
Reposted by Victoria HartMechanobiology Institute @mbisg.bsky.social · 09/09/2025What happens to packed cells in a monolayer during mitosis? @rlawson954.bsky.social presented varying experiments investigating shape and force changes, cell-cell junctions, and mechanics in mitotic cells, suggesting important roles for keratin and desmosomes #MBIMPG2025 @helenkmatthews.bsky.social 041
Victoria Hart @vichart33.bsky.social · 01/09/2025Interested in Pancreatic Cancer Research? We are gearing up to host our 7th Sheffield Pancreatic Cancer Research Network meeting! Check out the details at: sites.google.com/sheffield.ac... @mcb-sheffield.bsky.social @fohsheffield.bsky.socialsites.google.comSheffield Pancreatic Cancer Research Network - EventsUpcoming Events 052
Victoria Hart @vichart33.bsky.social · 07/07/2025Two fantastic talks at the 6th Pancreatic Cancer Research Network meeting by Megan Poxon and @isabelladavis00.bsky.social . Fancy speaking at the next one? Just get in touch! p.s. Don't forget to check out our new website 🔬https://sites.google.com/sheffield.ac.uk/pancreatic-cancer-network/home 031
Reposted by Victoria HartHelen Matthews @helenkmatthews.bsky.social · 02/07/2025Great talks by PhD students @isabelladavis00.bsky.social and Meg at the Sheffield Pancreatic Cancer Research Network meeting 👏 022
Victoria Hart @vichart33.bsky.social · 01/07/2025A beautiful day in the sunshine for our lovely lab summer social ☀️ @isabelladavis00.bsky.social @helenkmatthews.bsky.social @rlawson954.bsky.social 042
Reposted by Victoria HartImogen Ramsden @imogen-ramsden.bsky.social · 27/06/2025Last day of the #SmallGproteins meeting, great evening last night meeting researchers in the field hearing about people’s journeys, and gave advice on expressing a phosphorylated GTPase. Looking forward to Session 6 kicked off by @vickysanzmoreno.bsky.social! @biochemsoc.bsky.social #BiochemEvent 033
Victoria Hart @vichart33.bsky.social · 26/06/2025Now some adhesion and migration at #SGP25 🔬 hunting for Ras allies 🧫 polarised trafficking regulation adaptability during change 🧬 RhoA and Cdc42 pathway crosstalk Now onto the party! @biochemsoc.bsky.social #BiochemEvent 021
Victoria Hart @vichart33.bsky.social · 26/06/2025Now some adhesion and migration at #SGP25 🔬mechanosensing in cancer development 🧫 Rac1 driven plasticity in small cell lung cancer 🧬 actin in organelle transport 🧪 tool development to study spatial organisation of receptors @biochemsoc.bsky.social #BiochemEvent 020
Victoria Hart @vichart33.bsky.social · 26/06/2025Moving to a translational space 🔬 how we can revitalise therapies in response to resistance to Ras inhibitors 🧫 Arf6 alters matrix for metastatic niche in ovarian cancer 🧬 Novel phosphorylation regulates Arfs 🧪 Rac1 involvement in breast cancer metastases @biochemsoc.bsky.social #BiochemEvent 020
Victoria Hart @vichart33.bsky.social · 26/06/2025As day 3 of #SGP25 opens we heard brilliants talks covering… 🔬Ras lipid sensing to control localisation 🧫 Rnd3/RhoE importance in hepatocellular carcinoma 🔥 the role of Cdc42 in inflammation in response to wildfire smoke 🧪 the RhoA mutational landscape @biochemsoc.bsky.social #BiochemEvent 021
Victoria Hart @vichart33.bsky.social · 25/06/2025Next, we look at how to target our small G proteins 🔬innovations in the targeting of Ras from Revolution Medicines 🧫 translating non-canonical functions of kRas to find targeting combinations 🧬 developing and testing a GAP glue 🧪 mutant and WT Ras crosstalk @biochemsoc.bsky.social #BiochemEvent 011
Victoria Hart @vichart33.bsky.social · 25/06/2025As a side what a beautiful site for a conference, flowers everywhere in the sunshine ☀️ @biochemsoc.bsky.social #BiochemEvent 041
Victoria Hart @vichart33.bsky.social · 25/06/2025And we continue #SGP25 with 🔬RAP1GDS1 isoform specific importance in lung cancer 🧫 how kRas oncogenic enhanced proliferation can occur without hyperactive ERK or Akt 🧬 RhoGAP family interactions in endometrial cancer @biochemsoc.bsky.social #BiochemEvent 020
Reposted by Victoria HartImogen Ramsden @imogen-ramsden.bsky.social · 25/06/2025SGP25 Session 2 (Part 1): ⚙️ “Branchgetic” Ras mutations indicate effector selection 🔬 RAF biosensors to monitor acivity in live cells 💥 C2 domain boosts RasGAP activity 💊 RhoB-Ral complex a target for EGFR TK inhibition? @biochemsoc.bsky.social #BiochemEvent 021
Victoria Hart @vichart33.bsky.social · 25/06/2025Day 2 of #SGP25 of to a great start with ✨ unpicking Ras effector binding in different tissues ✨ developing RAF based biosensors ✨ C2 domains and GAP functionality ✨ how RhoB and Ral affect EGFT therapy in lung cancer @Biochemsoc #BiochemEvent 111
Reposted by Victoria HartImogen Ramsden @imogen-ramsden.bsky.social · 24/06/2025SGP25 Session 1 (Part 1): ⛓️ Mapping KRAS interactomes in organoid models 🧬 Isoform-specific KRAS vulnerabilities: one mutation, big difference 🔬 Novel tool tracks Ras mutation dynamics in vivo ✨ And a reminder that clear science communication empowers patients! @biochemsoc.bsky.social #BiochemEvent 021
Victoria Hart @vichart33.bsky.social · 24/06/2025Excited to be selected as a Social Media Contributor for Small G proteins in cellular signalling and disease 2025! 🧬 Follow along for insights into how these tiny but mighty proteins shape health and disease! #BiochemEvent @BiochemSoc #SmallGProteins #CellBiology #SciComm 041
Victoria Hart @vichart33.bsky.social · 23/06/2025I am excited to share our new Sheffield Pancreatic Cancer Research Network website! Please check it out at... sites.google.com/sheffield.ac... @fohsheffield.bsky.social @mcb-sheffield.bsky.socialsites.google.comSheffield Pancreatic Cancer Research NetworkMeet the Team 055
Victoria Hart @vichart33.bsky.social · 05/06/2025A brilliant talk that sparked great discussions! 020
Reposted by Victoria HartRachel Lawson @rlawson954.bsky.social · 14/04/2025Great to hear about the research going on in @mcb-sheffield.bsky.social at University of Sheffield. Short talks from @helenkmatthews.bsky.social and @erainerolab.bsky.social about the projects going on in their labs 😊 094
Victoria Hart @vichart33.bsky.social · 27/03/2025loved having to opportunity to discuss our work and have plenty of great suggestions! #biologists100 010
Victoria Hart @vichart33.bsky.social · 26/03/2025Excited to be in the lovely Liverpool for the 100 year anniversary of the @biologists.bsky.social. 010