iiinova — where your digital self keeps evolving

Abel Vertesy @vertesy.bsky.social · 06/10/2026

[6/6] We had invaluable help from many colleagues, including @sergeyisaev.bsky.social, @mzabolocki.bsky.social, Maria Novatchkova and Chong V. Li. I’m also grateful to my mentors: Juergen A Knoblich, Alexander van Oudenaarden, Edda Klipp, Ursula Kummer, @vmullerhun.bsky.social and Peter Csermely.

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Abel Vertesy @vertesy.bsky.social · 06/10/2026

[5/6] We found those elementary (cell-type intrinsic) rules of wiring and much more: reproducible network assembly, recurrent motifs and molecular signatures of connectivity. In TSC, these rules broke down, shifting networks toward less constrained wiring, which could explain elevated Ca²⁺ dynamics.

Marker genes across layer 4 excitatory neurons, across connectivity motifs.

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Abel Vertesy @vertesy.bsky.social · 06/10/2026

[4/6] Complex structures are built by external instructions (Eiffel Tower) or self-organization (termite hills). The developing brain uses both. But how much does it rely on self-organization? To ask this, we need a model with minimal external input: organoids, and the rules single neurons follow.

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Abel Vertesy @vertesy.bsky.social · 06/10/2026

[3/6] COSCO is a new experimental-computational method to map single-neuron synaptic connectivity together with transcriptomes using barcodes and sequencing. We recovered >86,000 neurons and >10,000 networks from 50+ human brain organoids across 6 cell lines—giving us the needed statistical power.

Graphical abstract of our preprint, Connectomics by Sequencing Reveals Self-Organizing Principles of Neuronal Networks in Cerebral Organoids

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Abel Vertesy @vertesy.bsky.social · 06/10/2026

[2/6] I thought the best way to understand its complexity was bottom-up & population-scale: map single-neuron connections across 1000s of networks, then use machine learning to find rules.Inspired by @tonyzador.bsky.social’s idea, we developed COSCO with @ramseynajm.bsky.social and Bálint Doleschall

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Abel Vertesy @vertesy.bsky.social · 06/10/2026

[1/6] Excited to share our work on bioRxiv! bit.ly/47CryUl from @knoblich-lab.bsky.social. It has been a huge part of my life, through some hard years, so seeing it come together feels special. I’ve long been fascinated by networks—especially the most complex one we know: the brain.

Single-neuron connectivity within human cerebral organoids, discovered by COSCO

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Abel Vertesy @vertesy.bsky.social · 06/10/2026

We are very happy to finally share our work with all of you! It was a long, but fascinating journey. I hope you will find it an exciting read!

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Reposted by Abel Vertesy

knoblich-lab.bsky.social @knoblich-lab.bsky.social · 06/10/2026

New preprint! 🧠🧬 Can cerebral organoids reveal intrinsic rules of circuit assembly? We think yes! COSCO maps >10,000 networks and reveals cell-type intrinsic wiring, reproducible network formation, recurrent motifs, molecular signatures of wiring and aberrant connectivity in TSC. bit.ly/47CryUl

Graphical abstract for Connectomics by Sequencing Reveals Self-Organizing Principles of Neuronal Networks in Cerebral Organoids

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Reposted by Abel Vertesy

Igor Adameyko @adameykolab.bsky.social · 11/07/2026

For the neural crest nerds: we love looking into transcriptional programs in single NCC cells. However, selective ribosomal modifications refine gene expression programs at a different scale. Here is our story about modified ribosomes in neural crest fate selection: www.nature.com/articles/s41...

nature.com

Ribosomal modifications are associated with mesenchymal fate selection in the neural crest lineage - Nature Communications

Neural crest cells differentiate into skeletogenic mesenchyme and neuro-glial lineages, thereby contributing to craniofacial formation. Here, single-cell analysis of cranial neural crest shows that sp...

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Abel Vertesy @vertesy.bsky.social · 13/07/2026

Paying peer reviewers pays off. I’ve argued this for years, and a well-designed experiment now supports it: much faster reviews and better quality. As with open access, we’ll need to learn how to use the model well – and watch for unintended consequences. www.nature.com/articles/d41...

nature.com

Why paying peer reviewers works, according to a journal’s editor-in-chief

A biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.

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Abel Vertesy @vertesy.bsky.social · 27/05/2026

Demonstration today, 27 May 2026, 13:00, starting in front of the Main Building of the University of Vienna.

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Abel Vertesy @vertesy.bsky.social · 27/05/2026

The Austrian gov. plans to cut university funding in 2028–2030 by ~-6%. Inflation heads to ~+4%. Our world & AT is changing ever faster (technology, society, the planet). To adapt, we need more education & research. #UnisRetten www.univie.ac.at/en/news/deta... www.univie.ac.at/aktuelles/un...

univie.ac.at

Budget – Universities call for demonstrations against budget cuts

Rector Sebastian Schütze: "Enormous reputational damage"

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Reposted by Abel Vertesy

Universität Wien / University of Vienna @univie.ac.at · 26/05/2026

#UnisRetten: Zukunft lässt sich nicht einsparen‼️✊ Gemeinsam auf die Straße gehen und ein Zeichen setzen -gegen die geplanten Einsparungen und für Qualität in Lehre & Forschung, für Chancengerechtigkeit & Zukunftsfähigkeit! 📅: 27. Mai, 13 Uhr 📍: Hauptgebäude Uni Wien www.univie.ac.at/aktuelles/un...

Demo in Wien! Mittwoch, 27. Mai, 13 Uhr. Für die Unis. Auf die Straße. Uni Wien Hauptgebäude.

Demoroute: Start Uni Wien, über das Wissenschaftsministerium zum Ballhausplatz.

Ablauf: 13 Uhr, Startkundgebung und Reden vor der Uni Wien (Hauptgebäude), 14 Uhr, Demozug zum Ballhausplatz über das BMBWF, 15:30 Uhr, Schlusskundgebung am Ballhausplatz

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