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Abel Vertesy

@vertesy.bsky.social
73 followers 40 following 10 posts

Single-cell Connectomics, Organoids, Neuroscience

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Abel Vertesy @vertesy.bsky.social · 06/10/2026
[5/6] We found those elementary (cell-type intrinsic) rules of wiring and much more: reproducible network assembly, recurrent motifs and molecular signatures of connectivity. In TSC, these rules broke down, shifting networks toward less constrained wiring, which could explain elevated Ca²⁺ dynamics.
Marker genes across layer 4 excitatory neurons, across connectivity motifs.
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Abel Vertesy @vertesy.bsky.social · 06/10/2026
[3/6] COSCO is a new experimental-computational method to map single-neuron synaptic connectivity together with transcriptomes using barcodes and sequencing. We recovered >86,000 neurons and >10,000 networks from 50+ human brain organoids across 6 cell lines—giving us the needed statistical power.
Graphical abstract of our preprint, Connectomics by Sequencing Reveals Self-Organizing Principles of Neuronal Networks in Cerebral Organoids
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Abel Vertesy @vertesy.bsky.social · 06/10/2026
[1/6] Excited to share our work on bioRxiv! bit.ly/47CryUl from @knoblich-lab.bsky.social. It has been a huge part of my life, through some hard years, so seeing it come together feels special. I’ve long been fascinated by networks—especially the most complex one we know: the brain.
Single-neuron connectivity within human cerebral organoids, discovered by COSCO
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