Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 06/10/2026Congratulations to Carolyn Rutter on two new NCI grants: an R01 developing a public tool and guidelines for calibrating cancer microsimulation models, and a CISNET colorectal cancer grant studying early onset CRC, new screening tests, and emerging treatments. 110
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 06/10/2026New from the Etzioni Lab: TrajSurv‑mPC uses a patient's full PSA and treatment history, rather than summary measures, to predict survival in metastatic prostate cancer. Developed and tested in MSK and VA cohorts. Published in JCO Clinical Cancer Informatics. ascopubs.org/doi/10.1200/...ascopubs.orgTrajSurv-mPC: Learning From Prostate-Specific Antigen Trajectories for Interpretable and Generalizable Survival Prediction in Metastatic Prostate Cancer | JCO Clinical Cancer InformaticsPurposeConventional prognostic models for metastatic prostate cancer (mPC) typically rely on summary features like prostate-specific antigen (PSA) doubling time, often obscuring informative longitudin... 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 25/09/2026Did you know? The Deep Learning Affinity Group (DLAG) at Fred Hutch hosts monthly seminars and journal club discussions on deep learning in biomedical research. Browse past sessions and an updated list of selected publications by Fred Hutch researchers: research.fredhutch.org/dlag/en.htmlresearch.fredhutch.orgDeep Learning Affinity Group (DLAG)The Deep Learning Affinity Group (DLAG) at Fred Hutchinson Cancer Center is a subfield of machine learning that has significantly advanced the field of AI by enabling the development of more accurate ... 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 22/09/2026Yingqi Zhao of our Biostatistics Program presented "Is ctDNA a Surrogate Endpoint to Evaluate Targeted Therapy Efficacy?" at the World Conference on Lung Cancer, in a session on thinking like a statistician. Check it out here: meetingsapp.iaslc.org/event/wclc20...meetingsapp.iaslc.orgES51. Think Like a Statistician to Become a Better Researcher⏬Presentation Slides will be accessible below within 24 hours after the session concludes⏬ Presentation References: Title: “On Using Machine Learning to Improve Lung Cancer Screening Globally” Referen... 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 17/09/2026🎉Congratulations to Ruth Etzioni & the CISNET Prostate Working Group on renewed NIH funding. The team will continue developing models to inform prostate cancer screening, staging, and treatment decisions, updating their frameworks to reflect current clinical practice. #prostatecancer 001
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 15/09/2026👀 Hey! We know him! Lucas Jing Liu, a member of the Etzioni Lab, develops innovative AI algorithms to enhance diagnosis, treatment, and recurrence monitoring of prostate and breast cancers. Check him out tomorrow with @sciantsmedia.com ! scholar.google.com/citations?us...scholar.google.com 021
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 09/09/2026🎉Congrats to our own Charles Kooperberg (Contact PI) & the PAGE team on renewed NIH funding for cardiometabolic disease genetics research. The team will study how genetic variants affect gene regulation across populations to inform more equitable precision medicine. reporter.nih.gov/search/hhmbg...reporter.nih.govRePORT ⟩ RePORTER 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 28/08/2026New episode of A Stochastic Podcast: Multicancer blood tests for cancer screening are here. The next challenge is evaluating them fast enough to keep up. Ruth Etzioni and @jsb-ucla.bsky.social discuss endpoints, trial design, and what her lab is working on. youtu.be/oKqXxbbBYfYyoutu.beRuth Etzioni: Rethinking Cancer Screening Trials for the Multicancer Test EraYouTube video by Fred Hutch Biostatistics Program 010
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 24/08/2026Susanna Fletcher Greer (V Foundation) highlights new JCI Insight research from Michael Haffner's lab at Fred Hutch: AI that reads pathology slides to help spot aggressive prostate cancer transformation. Congrats to coauthors Lucas Liu and Ruth Etzioni. www.linkedin.com/posts/susann...linkedin.comWhat If a Pathology Slide Could Tell Us How a Cancer Is Changing? | Susanna Fletcher Greer, Ph.D.For a fun Friday read: a new JCI Insight study highlights NEURAL-PC, an AI model that can detect aggressive metastatic prostate cancer and subtle neuroendocrine changes from routine pathology slides. ... 000
Reposted by Fred Hutch Biostatistics ProgramJingyi Jessica Li @jsb-ucla.bsky.social · 21/08/20265/5 Our commentary: authors.elsevier.com/a/1ndxd8YyDf... DOI: 10.1016/j.cels.2026.101706 Background debate: Sun et al. (2024): nature.com/articles/s41... Mukamel & Yu (2025): nature.com/articles/s41... Sun et al. reply (2025): nature.com/articles/s41...authors.elsevier.comPlease wait whilst we redirect youAll content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply. 011
Reposted by Fred Hutch Biostatistics ProgramJingyi Jessica Li @jsb-ucla.bsky.social · 21/08/20264/5 DE tests shifts in average gene expression. DV tests changes in expression heterogeneity across cells. They test different hypotheses. Considering both can provide a more comprehensive view of transcriptomic differences. 111
Reposted by Fred Hutch Biostatistics ProgramJingyi Jessica Li @jsb-ucla.bsky.social · 21/08/20263/5 This does not validate the original DE claims. Instead, it suggests that these previously noted genes exhibit changes in cell-to-cell variability rather than changes in mean expression. 101
Reposted by Fred Hutch Biostatistics ProgramJingyi Jessica Li @jsb-ucla.bsky.social · 21/08/20262/5 Across our reanalysis, we find no reliable DE genes. Yet differential variability (DV), an established but still underused complement to DE, identifies genes enriched for memory-related processes, including several previously highlighted as DE. 101
Reposted by Fred Hutch Biostatistics ProgramJingyi Jessica Li @jsb-ucla.bsky.social · 21/08/20261/5 New in Cell Systems: our commentary revisits a recent Nature debate over memory-associated gene-expression changes in single-cell data. The debate centered on whether reported differential-expression (DE) signals were statistically reliable. 211
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 20/08/2026We posted about this earlier in the summer, but always happy to have an excuse to celebrate a second time🎉 Congratulations, Ruth! 010
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 05/08/2026At #JSM2026 on Thursday, August 6, Yingye Zheng presents a new method for recalibrating chronic disease risk prediction models when applied to new populations with different baseline risk, shown to be robust across differing risk factor distributions. ww2.amstat.org/meetings/jsm... 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 05/08/2026At #JSM2026 on Thursday, August 6, Kemal Gogebakan discusses a statistical artifact in late-stage cancer incidence as a screening trial endpoint, using the recent UK MCED trial as a case study, and proposes a prevalence-adjusted analysis to correct it. ww2.amstat.org/meetings/jsm... 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 05/08/2026At #JSM2026 on Thursday, August 6, @wu-biostat.bsky.social presents ReDAQt, a new method that removes the effect of sequencing depth from diversity metrics in virome studies, succeeding where tools built for other omics data fall short. ww2.amstat.org/meetings/jsm... 111
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 05/08/2026At #JSM2026 on Thursday morning, August 6, Yimin Zhao presents a comprehensive benchmark of methods for conformal prediction under covariate shift, comparing 7 leading approaches across coverage, efficiency, and scalability. ww2.amstat.org/meetings/jsm... 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 05/08/2026🎉 Awards night! @jsb-ucla.bsky.social and Yingqi Zhao are being recognized as 2026 ASA Fellows tonight at the JSM Awards Ceremony in Boston. Congratulations to both on this well-earned honor. 🏆 #JSM2026 100
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 04/08/2026Congrats to Yuzheng Dun, who is chairing a Contributed Papers session at #JSM2026 on Aug 5. "Bayesian Methodology for Genomics" features talks spanning spatial proteomic imaging, TWAS, and high-dimensional mediation analysis in cancer genomics. ww2.amstat.org/meetings/jsm... 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 04/08/2026At #JSM2026 on Wednesday, August 5, Ruth Etzioni asks whether cancer screening trials should shift from mortality to surrogate endpoints like late-stage incidence, as new blood-based multi-cancer tests emerge. Ticketed lunch session, added fee. ww2.amstat.org/meetings/jsm... 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 04/08/2026At #JSM2026 on Wednesday, August 5, Jingyi Guan presents a new test for studying immune cell organization in spatial proteomics, accounting for patient-to-patient variation in tissue that standard methods often overlook. ww2.amstat.org/meetings/jsm... 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 04/08/2026At #JSM2026 on Wednesday, August 5, Yingqi Zhao discusses sequential decision making in clinical monitoring, weighing when to act on a data trend versus wait for more data, in settings like glucose monitoring and disease screening. tinyurl.com/YingqiJSM 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 03/08/2026At #JSM2026 on Tuesday, August 4, Chenxin (Flora) Jiang presents Nullstrap-DE, a new framework pairing the power of DESeq2 and edgeR with more reliable false discovery rate control for differential expression analysis. tinyurl.com/ChenxinJSM 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 03/08/2026Tomorrow at #JSM2026, Arnold Johnsen presents a new statistical approach for making cancer screening trials more efficient, using time to cancer diagnosis as a surrogate for survival to assess screening's effect on mortality. Demonstrated on National Lung Screening Trial data. tinyurl.com/ArnoldJSM 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 31/07/2026On August 3, Yifei Wang will talk about mGMM, a new statistical method for combining internal and external study data, applied to colorectal cancer data to reveal smoking associations that varied by tumor subtype. #JSM2026 ww2.amstat.org/meetings/jsm... 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 31/07/2026On Monday, August 3 at #JSM2026 @jsb-ucla.bsky.social will talk about clarifying the definition of "spatial niche" in spatial omics, proposing a taxonomy and reporting standards to make analyses more consistent and comparable. ww2.amstat.org/meetings/jsm... 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 31/07/2026On Monday, Aug 3 at #JSM2026, @programmingsun.bsky.social will talk about STpath, a framework that translates pathology image embeddings into biologically meaningful features like cell-type composition & gene expression, enabling their use in studies of clinical outcomes. tinyurl.com/WeiSunJSM2026 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 31/07/2026On Monday, Aug 3 at #JSM2026, Jing Ma will present a new mediation model for microbiome data, representing gut microbiome as a microbial balance to estimate community-level effects and identify key taxa, shown via gut microbiome ➡️ LBP ➡️liver fat pathway. tinyurl.com/MaJSM2026 121
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 31/07/2026On Sunday, August 2, Yuzheng Dun will talk about SRKAT at #JSM2026. SRKAT is a new statistical method for testing interactions between biological markers, applied to reveal sex-microbiome interactions linked to BMI and waist circumference. tinyurl.com/YuzhengDunJS... 111
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 31/07/2026This Sunday at #JSM2026 Si Liu will talk about using graph neural networks to extract comparable features from spatial proteomic data, in order to identify meaningful tumor domains. ww2.amstat.org/meetings/jsm... 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 28/07/2026Our Biostatistics Program will be well represented at JSM 2026 in Boston, Aug 1-6! Talks on digital pathology, spatial omics, causal inference, cancer screening, and more. More to come as each talk approaches. #JSM2026 ww2.amstat.org/meetings/jsm... 031
Reposted by Fred Hutch Biostatistics ProgramFred Hutch @fredhutch.org · 27/07/2026In case you need a little pick-me-up to start your week, courtesy of Fred Hutch’s Human Biology Division. 🔬🧫🤗 0104
Reposted by Fred Hutch Biostatistics ProgramFred Hutch @fredhutch.org · 20/07/2026Congrats to Drs. Steve Hahn, Ruth Etzioni and Ulrike Peters on their election to @washacadsci.bsky.social! They join 30 other scientists from across Washington state recognized for outstanding scientific achievement and a commitment to bringing trusted science to public policy decisions. 162
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 17/07/2026SeattleStatGROWS is back for its 4th year! 21 undergrads are starting 8 weeks of hands-on research with our faculty, kicked off with a lunch where program alumni met the new cohort, past meets present! 🎉 More info: www.fredhutch.org/en/education... 011
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 17/07/2026A great shot from an audience member of @jsb-ucla.bsky.social officially receiving her 2026 @iscb.bsky.social ISCB Fellowship! Congratulations again to our program head on this well earned honor. 🎉 021
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 16/07/2026Congratulations to our own Dr. Ruth Etzioni, elected to the Washington State Academy of Sciences! She was recognized for pioneering statistical models that transformed cancer early detection and screening policy, plus her leadership and mentorship across the field. 🎉 washacad.org/new-members-...washacad.orgNew Members Elected to Washington State Academy of Sciences - Washington State Academy of SciencesNew members were elected in recognition of their scientific achievement and willingness to work on behalf of the Academy for the benefit of Washington state. 030
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 13/07/2026🎉 Dr. Marlena Bannick joins the Fred Hutch Biostatistics Program as Assistant Professor starting 9/1/26! She's a UW Biostat PhD (advised by Ting Ye), FDA-OCE-ASA fellow, and co-developer of the RobinCar R packages for adaptive trial design. Welcome, Marlena! 🔗https://marlenabannick.com/marlenabannick.comMarlena Bannick, PhDBiostatistician at Seattle Children's Research Institute 010
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 09/07/2026New talk on our YouTube channel! Dr. Jean Feng (UCSF) asks when we can trust LLMs judging other LLMs, or humans adaptively selecting outputs to evaluate, and what statistical guarantees these common practices actually offer. youtu.be/_nhq-JcpWjgyoutu.beJean Feng: LLMs Judging LLMs and Humans Judging LLMs: Who Can We Trust?YouTube video by Fred Hutch Biostatistics Program 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 09/07/2026👀 We are super excited for Ben to bring his energy and ideas to Fred Hutch. Welcome, @biophysben.bsky.social !! 041
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 09/07/2026🎉 Welcoming @biophysben.bsky.social to our Biostat Program in January 2027! He works across ML, physics, and biology, using generative models to map genetic drivers of disease, infer gene networks from sister cell data, and predict cellular responses from gene co-fluctuations. 🎉benkuznets-speck.com 041
Reposted by Fred Hutch Biostatistics ProgramFred Hutch @fredhutch.org · 29/06/2026Tune in to @sciantsmedia.com Twitch stream tonight at 6pm PST as they raise money to benefit Fred Hutch and chat computational biology and blood-based biomarkers with Patrick McDeed, PhD from the Ha Lab! www.twitch.tv/sciants_streams 044
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 25/06/2026Great to see this from @matsen.bsky.social, who spoke at our for our AI Symposium this spring. His framing of agent orchestration around the manuscript as the source of truth is well worth a read. This is a terrific example of researchers sharing how they're actually using AI in their work. 010
Reposted by Fred Hutch Biostatistics Program@doublewhammied @doublewhammied.bsky.social · 25/06/2026" ... person-years (a 26% relative reduction), compared to 84 per 100K among avg-risk women (a 20% reduction)." 2/2 #CanSky This is great! Many thx to @fredhutch.org & #RuthEtzioni & her lab 4 this work! #MCD #cancerprevention #researchsaveslives #knowledgeispower www.fredhutch.org/content/www/...fredhutch.orgBreast cancer survivors may benefit from a yearly blood test to detect new cancersResearchers in the Etzioni Lab are using modeling to assess the benefit of using yearly multicancer early detection blood tests to catch new cancers in breast cancer survivors. 021
Reposted by Fred Hutch Biostatistics Program@doublewhammied @doublewhammied.bsky.social · 25/06/2026"Across every scenario, multicancer screening reduced the rate of late-stage #cancer Dx & the benefit was consistently greater 4 #breastcancer survivors than 4 avg-risk women. In the most optimistic scenario, ER- survivors saw up to 111 late-stage diagnoses prevented per 100K ..." 1/2 #CanSkyfredhutch.orgBreast cancer survivors may benefit from a yearly blood test to detect new cancersResearchers in the Etzioni Lab are using modeling to assess the benefit of using yearly multicancer early detection blood tests to catch new cancers in breast cancer survivors. 132
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 23/06/2026📽️Anil Palepu on evaluating AI clinical reasoning through OSCE-style frameworks instead of static exams. Talk covers diagnostic dialogue, disease management, and a real-patient feasibility study. This was a special joint Biostat Seminar co-sponsored w/ @uwbiostat.bsky.social. youtu.be/Mcd6HHElzsgyoutu.beAnil Palepu on Conversational AI for Diagnosis and ManagementYouTube video by Fred Hutch Biostatistics Program 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 22/06/2026Breast cancer survivors face elevated risk of other cancers later on, but guidelines mostly just watch for recurrence. New modeling study from the Etzioni Lab finds annual multicancer blood testing could meaningfully cut late-stage diagnoses in this group. www.fredhutch.org/en/news/spot...fredhutch.orgBreast cancer survivors may benefit from a yearly blood test to detect new cancersResearchers in the Etzioni Lab are using modeling to assess the benefit of using yearly multicancer early detection blood tests to catch new cancers in breast cancer survivors. 000
Fred Hutch Biostatistics Program @fredhutchbiostat.bsky.social · 22/06/2026Li Lab Postdoc Changhu Wang received the Chen Hu Endowed Trainee Travel Fund award to present at RECOMB 2026. Congratulations, Changhu! More on Changhu Wang: jsb-lab.org/people/chang...jsb-lab.orgChanghu Wang – The Junction of Statistics and Biology 000