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Uriel Urquiza-Garcia

@uurquiza.bsky.social
301 followers 188 following 38 posts

Programming plants at the genome scale | Synthetic chromosomes, regulatory networks & quantitative biology | CEPLAS www.synthetic-biology.hhu.de/resear…

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Reposted by Uriel Urquiza-Garcia
Ralf Reski @reskilab.bsky.social · 07/05/2026
Moss Powering the Next Drug Frontier Chinese hamster ovary (#CHO) cells have been the gold standard for producing biologic drugs. Now, an unlikely contender—#moss—is offering a new path forward. #pharma #biopharmaceutical #nextgeneration www.genengnews.com/topics/biopr...
genengnews.com
Moss Powering the Next Drug Frontier
Eleva’s moss platform could transform production of complex biologics and rare disease treatments.
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Uriel Urquiza-Garcia @uurquiza.bsky.social · 05/04/2026
Amazing to see one week regenerating P. patens transformed with big DNA carrying a mCherrry, can’t wait for the genotyping soon and full genome sequencing afterwards #plantsyntheticgenomics
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Uriel Urquiza-Garcia @uurquiza.bsky.social · 11/02/2026
Finally I had a look to my Phytobricks ecosystem that I have been building as part of my research on plant synthetic biology now genomics. Looks like I have some hubs, perhaps already some signs of scale free network? #plantsyngenomics #moss #synPACs #beyondrecoding
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Uriel Urquiza-Garcia @uurquiza.bsky.social · 11/01/2026
Technical thread on why Liu et al.'s Cell Reports doi.org/10.1016/j.ce... paper validates some of our Urquiza-Garcia et al 2025 model predictions published in Molecular Systems Biology doi.org/10.1038/s443... 🧵
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Reposted by Uriel Urquiza-Garcia
bioRxiv Plant Bio @biorxiv-plants.bsky.social · 14/11/2025
Systemic and local regulation of root growth by vascular trehalose 6-phosphate is correlated with re-allocation of primary metabolites between shoots and roots www.biorxiv.org/content/10.1101/202…
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Reposted by Uriel Urquiza-Garcia
Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 26/07/2025
Our #cryoET of #plasmodesmata preprint is out! Will write more on it later. 🌿❄️
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Uriel Urquiza-Garcia @uurquiza.bsky.social · 25/06/2025
Bringing back to life some 10 year old constructs I did during my PhD CCA1pro:NanoLUC-PEST
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Reposted by Uriel Urquiza-Garcia
CEPLAS - Cluster of Excellence on Plant Sciences @ceplas.bsky.social · 22/05/2025
🎊 We made it!! @dfg.de has just announced that we have been successful with our CEPLAS III proposal in the current funding round of the Excellence Strategy! Many thanks to all our supporters! @hhu.de @unicologne.bsky.social @mpipz.bsky.social @fz-juelich.de @leibnizipk.bsky.social
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Uriel Urquiza-Garcia @uurquiza.bsky.social · 22/05/2025
@ceplas.bsky.social continues!! Let’s continue delivering excellent plant research now SMARTe plants in dynamic environments!
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Reposted by Uriel Urquiza-Garcia
Ralf Reski @reskilab.bsky.social · 28/03/2025
Moose – Die Gamechanger der Medizin und Forschung! Mein Interview für #FrischeFische auf YouTube. #Exzellenzinitiative #Moose #Medizin #Evolution #Forschung #scicomm #wisskomm @cibss.bsky.social #livMatS @biologyunifreiburg.bsky.social www.youtube.com/watch?v=JzgL...
youtube.com
🌱 Moose – Die Gamechanger der Medizin und Forschung! 🌱
YouTube video by Gary Silver
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Reposted by Uriel Urquiza-Garcia
Tonni Andersen @tonnigrubeandersen.bsky.social · 21/03/2025
Finally! Im so excited to present to culmination of many years of work from the fantastic Defeng Shen and some great collaborators. For details, I have made a digested thread below, but if you are more interested feel free to reach out (and read the paper of course). www.science.org/doi/10.1126/...
science.org
Apoplastic barriers are essential for nodule formation and nitrogen fixation in Lotus japonicus
Establishment of the apoplastic root barrier known as the Casparian strip occurs early in root development. In legumes, this area overlaps with nitrogen-fixing nodule formation, which raises the possi...
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Reposted by Uriel Urquiza-Garcia
Facundo Romani @fromani.bsky.social · 14/03/2025
After a lot of work, we are finally able to share this project about the cell cycle in Marchantia from the Haseloff lab. If you want to find out how cell division is controlled, you can’t miss out this one… #PlantScience #Synbio #EvoDevo www.biorxiv.org/content/10.1...
biorxiv.org
The minimal cell-cycle control system in Marchantia as a framework for understanding plant cell proliferation
The regulation of cell division is broadly conserved across eukaryotes, governed by cyclins and cyclin-dependent kinases (CDKs) to coordinate progression through the cell cycle. Plants have evolved a ...
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Reposted by Uriel Urquiza-Garcia
Björn Usadel @usadellab.bsky.social · 14/03/2025
If you are looking for published plant genomes www.plabipd.de/pubplant_mai... might be useful where Rainer is tracking species with genomes for almost 10 years now... time flies. As he has added new useful views, we thought it is time to summarize this. www.biorxiv.org/content/10.1...
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Reposted by Uriel Urquiza-Garcia
Ralf Reski @reskilab.bsky.social · 13/03/2025
Our updated preprint now on bioRxiv: Production of human papillomavirus type 16 virus-like particles in #Physcomitrella photobioreactors www.biorxiv.org/content/10.1...
biorxiv.org
Production of human papillomavirus type 16 virus-like particles in Physcomitrella photobioreactors
Human papillomavirus (HPV) infections are the main causal agent of cervical and other anogenital cancers. Modern HPV vaccines are based on virus-like particles (VLPs), which are self-assembling nanopa...
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Uriel Urquiza-Garcia @uurquiza.bsky.social · 10/03/2025
Laura Trimborn, [...] and Ute Hoecker CRY1 inhibits the activity of COP1 by competitively displacing substrates from COP1 pubmed.ncbi.nlm.nih.gov/40052249/
pubmed.ncbi.nlm.nih.gov
Cryptochrome 1 promotes photomorphogenesis in Arabidopsis by displacing substrates from the COP1 ubiquitin ligase - PubMed
In blue light, cryptochrome photoreceptors inhibit the key repressor of light signaling, the COP1/SPA ubiquitin ligase, to promote photomorphogenic responses. This inhibition relies on the direct inte...
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Reposted by Uriel Urquiza-Garcia
James Lloyd 🧬 @jamespblloyd.bsky.social · 09/03/2025
Our new review in @theplantjournal.bsky.social on synthetic gene circuits is out! I am super proud of this. I hope that it acts as a useful resource for people new to gene circuits. The switch-liker's guide to plant synthetic gene circuits onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
The switch‐liker's guide to plant synthetic gene circuits
Synthetic gene circuits have the potential to revolutionise how plants can be engineered by allowing highly customised gene expression patterns to be designed. Gene circuits can sense and integrate m....
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Reposted by Uriel Urquiza-Garcia
Leo Scheller @leoscheller.bsky.social · 26/02/2025
I’m happy to share that I will join the LIT in Regensburg (lit.eu) as a Group Leader in Structural Biochemistry in May. We will combine synthetic biology and protein design to develop synthetic receptors and protein therapeutics to improve immunotherapy. Job openings will be available soon!
lit.eu
Leibniz Institute for Immunotherapy
The LIT develops innovative therapies for the treatment of cancer, autoimmunity, and chronic inflammation by reprogramming immune cells.
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Uriel Urquiza-Garcia @uurquiza.bsky.social · 02/03/2025
My first students in Plant Synthetic Genomics put together a nice tool for biodesign automation of random DNA fragments for synthetic genomics applications. "Gearing up Golden Braid assembly for plant synthetic genomics with RepTiles" @hhu.de @ceplas.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Gearing up Golden Braid assembly for plant synthetic genomics with RepTiles
We have developed RepTiles, a system for generating traces of random DNA for synthetic genomics applications. The system uses synthetic random DNA domesticated using the Phytobricks syntax. RepTiles h...
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Reposted by Uriel Urquiza-Garcia
Sebastian S. Cocioba @atinygreencell.bsky.social · 02/03/2025
Hey can y'all check to see if the NCBI blastn page is working? Genbank page seems down, too. Same on your end? TYIA www.ncbi.nlm.nih.gov/genbank/
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Uriel Urquiza-Garcia @uurquiza.bsky.social · 02/03/2025
Is it my imagination or #NCBI is down? cannot access it from Germany
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Uriel Urquiza-Garcia @uurquiza.bsky.social · 20/02/2025
Abundant clock proteins point to missing regulation in the plant circadian clock www.embopress.org/doi/full/10.... first experimental determination of the abundance of transcription factors in Plants and for the circadian clock. It was such a challenge but finally out after peer review !!!
embopress.org
Abundant clock proteins point to missing molecular regulation in the plant circadian clock | Molecular Systems Biology
imageimage~100,000 copies of plant circadian clock proteins per cell were predicted from RNA levels and included in detailed models. Protein levels and DNA-binding were validated, using NanoLUC report...
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Reposted by Uriel Urquiza-Garcia
Robin Bisson @robinbisson.bsky.social · 14/02/2025
After becoming the 2nd FRS to quit over Elon Musk, @andrewmillar.bsky.social explains why Musk's actions "are not compatible with the conduct required of a fellow...they undermine the purpose of the Royal Society" The @royalsociety.org has called fellows to a 3rd March meeting as the crisis grows
researchprofessionalnews.com
‘I do not want a fellowship that can include such actions’ - Research Professional News
Elon Musk’s actions undermine the purpose of the Royal Society, writes resigning fellow Andrew Millar
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Uriel Urquiza-Garcia @uurquiza.bsky.social · 13/02/2025
@andrewmillar.bsky.social has resigned from the #RoyalSociety I hope others follow
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Reposted by Uriel Urquiza-Garcia
Sri Kosuri @srikosuri.bsky.social · 08/02/2025
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
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Uriel Urquiza-Garcia @uurquiza.bsky.social · 09/02/2025
Insighful review from André Marques nph.onlinelibrary.wiley.com/share/5UPJFE...
nph.onlinelibrary.wiley.com
Centromere diversity and its evolutionary impacts on plant karyotypes and plant reproduction
You have to enable JavaScript in your browser's settings in order to use the eReader.
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Reposted by Uriel Urquiza-Garcia
CIBSS – Centre for Integrative Biological Signalling Studies @cibss.bsky.social · 21/01/2025
#Tomorrow @uni-freiburg.de: panel discussion on the pros and cons of #GreenGeneTech. Join us for an exciting discussion! 👉 kurzlinks.de/twhu @friasunifreiburg.bsky.social@testbiotech.bsky.social@mpi-mp-potsdam.bsky.social@bund.net@ceplas.bsky.social@oekoprog.bsky.social@progagrarwende.bsky.social
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Uriel Urquiza-Garcia @uurquiza.bsky.social · 09/01/2025
I wonder when will DNA be a commodity like electricity
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Reposted by Uriel Urquiza-Garcia
Rita Strack @ritastrack.bsky.social · 31/12/2024
www.nature.com/articles/s41...
nature.com
A practical, biomimetic, one-pot synthesis of firefly luciferin - Scientific Reports
Scientific Reports - A practical, biomimetic, one-pot synthesis of firefly luciferin
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Reposted by Uriel Urquiza-Garcia
Review Commons @reviewcommons.org · 19/12/2024
Abundant clock proteins point to missing molecular regulation in the plant circadian clock. Urquiza-García et al 2024; study by @andrewmillar.bsky.social bioRxiv doi.org/10.1101/2024.09.03.609973 #preprintpeerreview by Review Commons eeb.embo.org/doi/10.1101/2024.09.03.609973.
doi.org
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Uriel Urquiza-Garcia @uurquiza.bsky.social · 19/12/2024
A step by step protocol for absolute quantification of protein using Arabidopsis thaliana transgenic lines carrying NanoLUC-tagged genes www.protocols.io/view/a-step-...
protocols.io
A step by step protocol for absolute quantification of protein using Arabidopsis thaliana transgenic lines ...
Quantification of protein levels in absolute units will allow testing quantitative models of gene regulatory networks. Better quantitative models have application in fundamental...
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