The ‘Clip-Cycle’ approach is a versatile and modular synthetic method for the synthesis of aza-heterocycles via sequential cross metathesis and aza-Michael reactions. In this manuscript, a series of…

Scientists have shown how plants produce powerful natural chemicals that could help in the production of new medicines in more environmentally friendly ways.

The Securinega alkaloids are a diverse family of polycyclic alkaloids with broad biological importance. In this study, a formal [4+2] cycloaddition strategy has been used to complete the biomimetic to...

Non-natural biotransformations, such as alkene cyclopropanation through carbene insertion, have been demonstrated for the hemoproteins cytochrome P450 and myoglobin, but have not been investigated…

Unspecific Peroxygenases (UPOs) catalyze the selective oxygenation of organic substrates using only hydrogen peroxide as the external oxidant. The PaDa-I variant of the UPO from Agrocybe aegerita cat...

Nature Chemistry - Aza-heterocycles with rings of more than 6 members are underrepresented in medicinal chemistry owing to challenges with their synthesis. Now, the conversion of 5- and 6-membered...

Macrocycles and medium-sized rings are important in many scientific fields and technologies but are hard to make using current methods, especially on a large scale. Outlined herein is a strategy by wh...