Despite the significance of nicotine, a neuroactive alkaloid produced by tobacco, its biosynthesis has remained elusive. Here, the authors report the in vitro and in planta reconstruction of a fo...

Scientists have shown how plants produce powerful natural chemicals that could help in the production of new medicines in more environmentally friendly ways.

Scientists have shown how plants produce powerful natural chemicals that could help in the production of new medicines in more environmentally friendly ways.

The Securinega alkaloids are a diverse family of polycyclic alkaloids with broad biological importance. In this study, a formal [4+2] cycloaddition strategy has been used to complete the biomimetic to...

Nicotine is a neuroactive alkaloid produced by tobacco (Nicotiana tabacum) as a defense against herbivory, and an addictive stimulant that has been used by humans for millennia. Despite its significan...

We are currently recruiting for two post-doc positions in the Lichman lab that require similar skills and experience. We aim to do a joint recruitment process with a single interview. If you apply...

Brilliant new paper out in Nature Communications led by Dr Tomasz Czechowski and Prof Ian Graham. Sandesh and Benjy made some modest but valuable contributions to this nice story on unusual linear...

Triterpenoids and steroids are structurally complex polycyclic natural products with potent biological functions, for example, as hormones. In all eukaryotes, the carbon skeletons of these compounds a...

Abstract. Monoterpenoids are small volatile molecules produced by many plants that have applications in consumer products and healthcare. Plants from the m

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Discovery, understanding and engineering of ​plant natural product biosynthesis.