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trisre.bsky.social

@trisre.bsky.social

29 followers 79 following 9 posts

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trisre.bsky.social @trisre.bsky.social · 05/10/2026

Lol.

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trisre.bsky.social @trisre.bsky.social · 03/08/2026

For some reason they appear to have arthropodean legs to me

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Reposted by @trisre.bsky.social

Sophia Paul @sophia-pa.bsky.social · 08/07/2026

Excited to share my paper! 🥳 Today in #Nature we reveal an 8 MDa Hdr electron bifurcating super-assembly in class I methanogens that couples the first and last steps of hydrogenotrophic methanogenesis. A lineage-specific adaptation to anaerobic niches. www.nature.com/articles/s41...

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Reposted by @trisre.bsky.social

Gyana Prakash Mahapatra @gyanaprakash.bsky.social · 27/06/2026

Excited to share our new preprint! How does the cyanobacterial hydrogenase HoxEFUYH drive photosynthetic H₂ production? Using #cryoEM, biochemistry, FTIR and EPR spectroscopy, we reveal its molecular mechanism, including the basis of electron bifurcation/confurcation. www.biorxiv.org/content/10.6...

biorxiv.org

Electron confurcation drives photosynthetic H2 production in cyanobacteria

Cyanobacteria are major contributors to global photosynthesis and are intensively studied for sustainable green H2 production. Central to this process is the bidirectional [NiFe]-hydrogenase HoxEFUYH,...

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trisre.bsky.social @trisre.bsky.social · 07/07/2026

6/ Many thanks to all the colleagues and collaborators who made this work possible. After defending my PhD two weeks ago, this preprint further marks the end of my PhD in the Schuller lab, five formative years in Marburg! Thanks to everyone who contributed, supported, and inspired me along the way.

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trisre.bsky.social @trisre.bsky.social · 06/07/2026

5/ While the exact mechanism of sodium pumping remains unknown, we hypothesise the metallocluster acts as the Lewis acid activating CoM. Sodium ion binding at the conserved site may be destabilised by CoM deprotonation putatively propagated via Asn and Asp residues, triggering ion translocation.

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trisre.bsky.social @trisre.bsky.social · 06/07/2026

4/ MtrA binding to MtrCDE and corrinoid insertion also correlate with rearrangements within the MtrCDE membrane plane. MtrD 48–68 undergoes the largest shift, a movement at the MtrDE interface that widens a potential sodium ion translocation pathway.

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trisre.bsky.social @trisre.bsky.social · 06/07/2026

3/ Binding and insertion of the corrinoid into the MtrCDE vestibule correlates with changes of CoM binding. Although not unambiguously assignable, an elongated feature appears at the apical iron of the cluster, implicating the clusters direct participation in methyl transfer.

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trisre.bsky.social @trisre.bsky.social · 06/07/2026

2/ The anaerobic dataset also shows close-to-catalytic conformational states of MtrA at MtrH and the MtrCDE trimer.

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trisre.bsky.social @trisre.bsky.social · 06/07/2026

1/ Happy to share our preprint! The Mtr complex catalyses the second-to-last step of the methanogenesis and is an essential bioenergetic machine in most methanogenic archaea. Anaerobic cryo-EM of Mtr reveals a nitrogenase-like metallocluster bound at its active site! www.biorxiv.org/content/10.6...

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Schuller Jan @schullerjm.bsky.social · 04/06/2025

Proud to present the lab's latest work. The full structure of the sodium translocating methyltransferase (Mtr) bound to a small oxygen-responsive small protein MtrI. Work by Tristan and together with @schmitzstreitslab.bsky.social . www.biorxiv.org/content/10.1101/2025.06.02.657420v1

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trisre.bsky.social @trisre.bsky.social · 28/01/2025

First time using deepseek 😅

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