Reposted by Toshi Furukawa
Excellent work by @ploederl.bsky.social , @floriannaudet.bsky.social & colleagues. There had bn 2 NMAs published in @thelancet.com on meds 4 pediatric depression reporting o'all SMDs that seemed 2 good 2 B true, then found the culprit–an outlier with an SMD>4!
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
A Re‐Appraisal of Three Network Meta‐Analyses to Explain the Discrepancy in Findings for the Efficacy of Fluoxetine for the Treatment of Depression in Children and Adolescents
Objective To explain discrepant findings for fluoxetine's efficacy in three influential network meta-analyses (NMAs) of treatments for pediatric depression, which led to conflicting clinical recomme...