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Tom Brett

@tombrettlab.bsky.social
404 followers 468 following 25 posts

PhD AAZF ATSF FAHA. Associate Prof of Medicine at WashU, Co-Director BBSB PhD Program, Structural Biology, Molecular Mechanisms of Inflammation, lung disease, Alzheimer's Disease. Girlsdad. Outdoor Enthusiast.

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Reposted by Tom Brett
Jen A-Brett @jablab3.bsky.social · 22/03/2025
A little time off the grid….
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NPR @npr.org · 04/03/2025
Harrison, whose plasma contained a rare antibody, rolled up his sleeve 1,173 times from 1954 to 2018. The Australian is credited with helping 2.4 million babies and advancing scientific research.
npr.org
James Harrison, whose blood donations saved over 2 million babies, has died
Harrison, whose plasma contained a rare antibody, rolled up his sleeve 1,173 times from 1954 to 2018. The Australian is credited with helping 2.4 million babies and advancing scientific research.
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Tom Brett @tombrettlab.bsky.social · 25/02/2025
George was a great guy. I vividly remember meeting him at a mixer at the IUCr meeting in Seattle in '97 when I was a grad student. We had an hour long conversation about SHELX and crystallography and other things over beers. Both a deep thinker and down to earth guy. He leaves a big impact.
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Tom Brett @tombrettlab.bsky.social · 25/02/2025
Fun fact about George Sheldrick: he wrote a paper on his SHELX software (that everyone uses for small molecule crystallography) in Acta Cryst A which caused the journal to go from Impact Factor 2 to an IF = 50. Spawned discussion on the relevance of IFs. Huge impact.
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Celeste Karch @karchlab.bsky.social · 11/02/2025
Mapping Trem2 ligand interactions by the group who brought us the first Trem2 crystal structure @tombrettlab.bsky.social
molecularneurodegeneration.biomedcentral.com
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands - Molecular Neurodegeneration
TREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s disease and other neurodegenerative diseases. While a number of TREM2 ligands have bee...
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Extracellular Life @extracellularlife.bsky.social · 08/02/2025
Right about now wondering how many Trump voters work at Universities in: Facilities Management Environmental Services Construction/renovation projects (including steel workers, HVAC, electrical, plumbing, painters) Large equipment installation or repair Security IT Need I go on…..
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Tom Brett @tombrettlab.bsky.social · 02/02/2025
One of the joys of mentoring is getting a glimpse into your students “outside the lab” life. Got to see the amazing #LNYF25 performance including our amazing undergrad researcher Cynthia Zhi!
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Tom Brett @tombrettlab.bsky.social · 12/01/2025
Beautiful day for a snow hike with @jablab3.bsky.social ! Really amazing out there today!
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Tom Brett @tombrettlab.bsky.social · 10/01/2025
I am so thrilled to share our latest collab with @jablab3.bsky.social ! Structural mapping of #TREM2 ligand interactions by #BLI. Led by Jessica Greven; thanks to big contributions by Josh Wydra, Cynthia Zhi,... molecularneurodegeneration.biomedcentral.com/articles/10....
molecularneurodegeneration.biomedcentral.com
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands - Molecular Neurodegeneration
TREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s disease and other neurodegenerative diseases. While a number of TREM2 ligands have bee...
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Jen A-Brett @jablab3.bsky.social · 09/01/2025
Check out the latest from our groups on TREM2, driven by rockstar postbac Jess Greven and @tombrettlab.bsky.social! @washumedicine.bsky.social doi.org/10.1186/s130...
doi.org
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands - Molecular Neurodegeneration
TREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s disease and other neurodegenerative diseases. While a number of TREM2 ligands have bee...
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Tom Brett @tombrettlab.bsky.social · 05/01/2025
As a Minnesota native, I can’t pass up the opportunity for a snow run! Nice storm out there!
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Altmetric @altmetric.com · 05/01/2025
Right, fun’s over, back to our regularly scheduled programming.
Drake preference meme - new year, new me vs new year new memes
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Tom Brett @tombrettlab.bsky.social · 04/01/2025
You know how the emails pile up over the holidays, and when you clean your inbox out by quick screen/delete, you hope you didn't get rid of something important? Just found out we @jablab3.bsky.social had a big paper accepted a week ago because the notice got deleted. Happy discoveries!
media.tenor.com
a person is typing on a keyboard with the words deleting delete intensifies
ALT: a person is typing on a keyboard with the words deleting delete intensifies
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Tom Brett @tombrettlab.bsky.social · 02/01/2025
Achievement unlocked! Chestnuts roasted on an open fire! Happy New Year to all!
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Extracellular Life @extracellularlife.bsky.social · 31/12/2024
Had the opportunity tonight to say Hi to my ‘baby blue’
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Extracellular Life @extracellularlife.bsky.social · 30/12/2024
Photo credit in image, I NEED to see this bird that is reportedly in the area.
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Jen A-Brett @jablab3.bsky.social · 25/12/2024
Happy Christmas!🎄
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Jen A-Brett @jablab3.bsky.social · 26/12/2024
Ok, finally a science post for BlueSky: Check out our latest editorial in @TheJHLT, strong work as always from Ghandi (@Ghandi_Hassan_ on X) www.sciencedirect.com/science/arti...
sciencedirect.com
Harnessing Mesenchymal Stem Cells for Improving Lung Transplant Outcomes
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Jen A-Brett @jablab3.bsky.social · 14/12/2024
Jim Manley trumpet at Jazz STL
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Minnesota Vikings @vikings.bsky.social · 16/12/2024
Tomorrow night. Let it SKOL. #WinterWhiteout ❄️
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Baptiste Lacoste @blacoste.bsky.social · 08/12/2024
www.nature.com/articles/s41...
nature.com
Brain endothelial GSDMD activation mediates inflammatory BBB breakdown - Nature
Lipopolysaccharide-induced breakdown of the blood–brain barrier requires activation of GSDMD-mediated plasma membrane permeabilization and pyroptosis in brain endothelial cells.
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Jen A-Brett @jablab3.bsky.social · 07/12/2024
He doesn’t get it. That’s ok. Fellow karaoke enthusiasts IYKYK ❤️ 🎤
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Jen A-Brett @jablab3.bsky.social · 06/12/2024
👀!!!
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Extracellular Life @extracellularlife.bsky.social · 03/12/2024
Interesting riff on science inspired by a story about Chappell Roan. I like it. Equally good food for those: 1) quietly struggling to find the motivation to keep going with their science 2) ignorantly raging about the process and taxpayer value of science www.instagram.com/reel/DCjzrMJ...
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Jen A-Brett @jablab3.bsky.social · 10/12/2024
Some know I have a thing for making playlists, but top 4% worldwide? Ok 🤣 If you wanna check them out Jen AB on @Spotify sites.wustl.edu/jablab (we all know the winner is @Hozier)
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Tom Brett @tombrettlab.bsky.social · 10/12/2024
We are recruiting for Investigator (Tenure) track faculty @WUSTL in the Dept of Pathology and Immunology; Division of Lab and Genomic Medicine. Official details can be found here: pathology.wustl.edu/wp-content/u...
pathology.wustl.edu
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Tom Brett @tombrettlab.bsky.social · 08/12/2024
Beautiful morning for #HotChocolate run with @jablab3.bsky.social and Jess Greven!
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Tom Brett @tombrettlab.bsky.social · 01/12/2024
This is very interesting. And it DOES NOT mean that TREM2 is not a good target. It's a complex target.
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Extracellular Life @extracellularlife.bsky.social · 30/11/2024
Seasonal confusion
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Jen A-Brett @jablab3.bsky.social · 30/11/2024
What’s better than a run in the rain….?
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Tom Brett @tombrettlab.bsky.social · 29/11/2024
Things to love about Thanksgiving: Turkey Trots, wine, and family! @jablab3.bsky.social
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Jen A-Brett @jablab3.bsky.social · 28/11/2024
Happy Thanksgiving to all! 🍁🦃
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Mary Munson @marymunson4.bsky.social · 25/11/2024
My lab at UMass Chan Med School uses a variety of approaches to elucidate the molecular mechanisms of membrane traffic. Striving to make academic science a more diverse, equitable, welcoming and inclusive place. Incoming President for the American Society for Cell Biology (ASCB)! Opinions are mine.
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Tom Brett @tombrettlab.bsky.social · 24/11/2024
More backyard gardening! First cauliflower of fall!
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Tom Brett @tombrettlab.bsky.social · 24/11/2024
Beautiful Sunday trail run with @jablab3.bsky.social !
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Extracellular Life @extracellularlife.bsky.social · 24/11/2024
It just don’t get better than this…..
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Tom Brett @tombrettlab.bsky.social · 24/11/2024
Beautiful Sunday trail run with @jablab3.bsky.social !
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Extracellular Life @extracellularlife.bsky.social · 23/11/2024
Bluebirds!!!! 💙
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Altmetric @altmetric.com · 23/11/2024
"Knowledge is in every country the surest basis of public happiness.' - George Washington #AcademicSky #Altmetrics #HigherEd
A blue Altmetric badge with a 10 in the centre
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Jay 🦋 @jay.bsky.team · 23/11/2024
Did you know there’s a site to search for starter packs of people to follow? Built by @mubashariqbal.com blueskydirectory.com/starter-pack...
blueskydirectory.com
Bluesky Starter Packs - Bluesky Directory
Browse a list of Bluesky Starter Packs. Discover and connect with your community on Bluesky
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Tom Brett @tombrettlab.bsky.social · 23/11/2024
More backyard gardening! First fall veggies! Broccoli and shallots!
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 20/11/2024
Good write up of BlueSky #MedSky by @kristinafiore.bsky.social feat. BlueSky elders: @mdaware.org @gavinyamey.bsky.social @nickmark.bsky.social @kiswanson.bsky.social and @kidneyboy.bsky.social of course www.medpagetoday.com/special-repo...
medpagetoday.com
Physicians Flock to Bluesky, Hoping to Leave X Behind
Many compare it to the early days of Twitter
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Tom Brett @tombrettlab.bsky.social · 19/11/2024
Backyard gardening! Fall crops are getting close to harvest time! Broccoli and cauliflower!
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KaminskiMed @kaminskimed.bsky.social · 18/11/2024
This should be mandatory reading for Presidents of Universities and Academic Societies. Also should be printed, framed and hung in their office: "Engage with courage, tenacity, strength and unity. Do NOT obey in advance" #ScienceMatters #NeutralityIsComplicity
nature.com
Scientists must hold President Trump to account with courage and unity
Despite many seeing the result as a step backwards, the research community should engage with the new administration with courage, tenacity, strength and unity.
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Extracellular Life @extracellularlife.bsky.social · 18/11/2024
Not even sure my alter ego is needed here, but alas, connect the dots as desired. My view on the way to ICU this morning. Hello 🦋
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Jen A-Brett @jablab3.bsky.social · 18/11/2024
Wow! People are here! A beautiful sky pic to kick it off!
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