Reposted by Tom BrettNPR @npr.org · 04/03/2025Harrison, whose plasma contained a rare antibody, rolled up his sleeve 1,173 times from 1954 to 2018. The Australian is credited with helping 2.4 million babies and advancing scientific research.npr.orgJames Harrison, whose blood donations saved over 2 million babies, has diedHarrison, whose plasma contained a rare antibody, rolled up his sleeve 1,173 times from 1954 to 2018. The Australian is credited with helping 2.4 million babies and advancing scientific research. 518223304351
Tom Brett @tombrettlab.bsky.social · 25/02/2025George was a great guy. I vividly remember meeting him at a mixer at the IUCr meeting in Seattle in '97 when I was a grad student. We had an hour long conversation about SHELX and crystallography and other things over beers. Both a deep thinker and down to earth guy. He leaves a big impact. 150
Tom Brett @tombrettlab.bsky.social · 25/02/2025Fun fact about George Sheldrick: he wrote a paper on his SHELX software (that everyone uses for small molecule crystallography) in Acta Cryst A which caused the journal to go from Impact Factor 2 to an IF = 50. Spawned discussion on the relevance of IFs. Huge impact. 030
Reposted by Tom BrettCeleste Karch @karchlab.bsky.social · 11/02/2025Mapping Trem2 ligand interactions by the group who brought us the first Trem2 crystal structure @tombrettlab.bsky.socialmolecularneurodegeneration.biomedcentral.comBiophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands - Molecular NeurodegenerationTREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s disease and other neurodegenerative diseases. While a number of TREM2 ligands have bee... 041
Reposted by Tom BrettExtracellular Life @extracellularlife.bsky.social · 08/02/2025Right about now wondering how many Trump voters work at Universities in: Facilities Management Environmental Services Construction/renovation projects (including steel workers, HVAC, electrical, plumbing, painters) Large equipment installation or repair Security IT Need I go on….. 032
Tom Brett @tombrettlab.bsky.social · 02/02/2025One of the joys of mentoring is getting a glimpse into your students “outside the lab” life. Got to see the amazing #LNYF25 performance including our amazing undergrad researcher Cynthia Zhi! 020
Tom Brett @tombrettlab.bsky.social · 12/01/2025Beautiful day for a snow hike with @jablab3.bsky.social ! Really amazing out there today! 051
Tom Brett @tombrettlab.bsky.social · 10/01/2025I am so thrilled to share our latest collab with @jablab3.bsky.social ! Structural mapping of #TREM2 ligand interactions by #BLI. Led by Jessica Greven; thanks to big contributions by Josh Wydra, Cynthia Zhi,... molecularneurodegeneration.biomedcentral.com/articles/10....molecularneurodegeneration.biomedcentral.comBiophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands - Molecular NeurodegenerationTREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s disease and other neurodegenerative diseases. While a number of TREM2 ligands have bee... 141
Reposted by Tom BrettJen A-Brett @jablab3.bsky.social · 09/01/2025Check out the latest from our groups on TREM2, driven by rockstar postbac Jess Greven and @tombrettlab.bsky.social! @washumedicine.bsky.social doi.org/10.1186/s130...doi.orgBiophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands - Molecular NeurodegenerationTREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s disease and other neurodegenerative diseases. While a number of TREM2 ligands have bee... 031
Tom Brett @tombrettlab.bsky.social · 05/01/2025As a Minnesota native, I can’t pass up the opportunity for a snow run! Nice storm out there! 030
Reposted by Tom BrettAltmetric @altmetric.com · 05/01/2025Right, fun’s over, back to our regularly scheduled programming. 0554
Tom Brett @tombrettlab.bsky.social · 04/01/2025You know how the emails pile up over the holidays, and when you clean your inbox out by quick screen/delete, you hope you didn't get rid of something important? Just found out we @jablab3.bsky.social had a big paper accepted a week ago because the notice got deleted. Happy discoveries!media.tenor.coma person is typing on a keyboard with the words deleting delete intensifiesALT: a person is typing on a keyboard with the words deleting delete intensifies 021
Tom Brett @tombrettlab.bsky.social · 02/01/2025Achievement unlocked! Chestnuts roasted on an open fire! Happy New Year to all! 110
Reposted by Tom BrettExtracellular Life @extracellularlife.bsky.social · 31/12/2024Had the opportunity tonight to say Hi to my ‘baby blue’ 021
Reposted by Tom BrettExtracellular Life @extracellularlife.bsky.social · 30/12/2024Photo credit in image, I NEED to see this bird that is reportedly in the area. 032
Reposted by Tom BrettJen A-Brett @jablab3.bsky.social · 26/12/2024Ok, finally a science post for BlueSky: Check out our latest editorial in @TheJHLT, strong work as always from Ghandi (@Ghandi_Hassan_ on X) www.sciencedirect.com/science/arti...sciencedirect.comHarnessing Mesenchymal Stem Cells for Improving Lung Transplant Outcomes 021
Reposted by Tom BrettMinnesota Vikings @vikings.bsky.social · 16/12/2024Tomorrow night. Let it SKOL. #WinterWhiteout ❄️ 218011
Reposted by Tom BrettBaptiste Lacoste @blacoste.bsky.social · 08/12/2024www.nature.com/articles/s41...nature.comBrain endothelial GSDMD activation mediates inflammatory BBB breakdown - NatureLipopolysaccharide-induced breakdown of the blood–brain barrier requires activation of GSDMD-mediated plasma membrane permeabilization and pyroptosis in brain endothelial cells. 04311
Reposted by Tom BrettJen A-Brett @jablab3.bsky.social · 07/12/2024He doesn’t get it. That’s ok. Fellow karaoke enthusiasts IYKYK ❤️ 🎤 051
Reposted by Tom BrettExtracellular Life @extracellularlife.bsky.social · 03/12/2024Interesting riff on science inspired by a story about Chappell Roan. I like it. Equally good food for those: 1) quietly struggling to find the motivation to keep going with their science 2) ignorantly raging about the process and taxpayer value of science www.instagram.com/reel/DCjzrMJ... 012
Reposted by Tom BrettJen A-Brett @jablab3.bsky.social · 10/12/2024Some know I have a thing for making playlists, but top 4% worldwide? Ok 🤣 If you wanna check them out Jen AB on @Spotify sites.wustl.edu/jablab (we all know the winner is @Hozier) 031
Tom Brett @tombrettlab.bsky.social · 10/12/2024We are recruiting for Investigator (Tenure) track faculty @WUSTL in the Dept of Pathology and Immunology; Division of Lab and Genomic Medicine. Official details can be found here: pathology.wustl.edu/wp-content/u...pathology.wustl.edu 01012
Tom Brett @tombrettlab.bsky.social · 08/12/2024Beautiful morning for #HotChocolate run with @jablab3.bsky.social and Jess Greven! 150
Tom Brett @tombrettlab.bsky.social · 01/12/2024This is very interesting. And it DOES NOT mean that TREM2 is not a good target. It's a complex target. 031
Reposted by Tom BrettExtracellular Life @extracellularlife.bsky.social · 30/11/2024Seasonal confusion 031
Reposted by Tom BrettJen A-Brett @jablab3.bsky.social · 30/11/2024What’s better than a run in the rain….? 261
Tom Brett @tombrettlab.bsky.social · 29/11/2024Things to love about Thanksgiving: Turkey Trots, wine, and family! @jablab3.bsky.social 061
Reposted by Tom BrettMary Munson @marymunson4.bsky.social · 25/11/2024My lab at UMass Chan Med School uses a variety of approaches to elucidate the molecular mechanisms of membrane traffic. Striving to make academic science a more diverse, equitable, welcoming and inclusive place. Incoming President for the American Society for Cell Biology (ASCB)! Opinions are mine. 818420
Tom Brett @tombrettlab.bsky.social · 24/11/2024More backyard gardening! First cauliflower of fall! 030
Reposted by Tom BrettTom Brett @tombrettlab.bsky.social · 24/11/2024Beautiful Sunday trail run with @jablab3.bsky.social ! 161
Reposted by Tom BrettExtracellular Life @extracellularlife.bsky.social · 24/11/2024It just don’t get better than this….. 022
Tom Brett @tombrettlab.bsky.social · 24/11/2024Beautiful Sunday trail run with @jablab3.bsky.social ! 161
Reposted by Tom BrettExtracellular Life @extracellularlife.bsky.social · 23/11/2024Bluebirds!!!! 💙 011
Reposted by Tom BrettAltmetric @altmetric.com · 23/11/2024"Knowledge is in every country the surest basis of public happiness.' - George Washington #AcademicSky #Altmetrics #HigherEd 0192
Reposted by Tom BrettJay 🦋 @jay.bsky.team · 23/11/2024Did you know there’s a site to search for starter packs of people to follow? Built by @mubashariqbal.com blueskydirectory.com/starter-pack...blueskydirectory.comBluesky Starter Packs - Bluesky DirectoryBrowse a list of Bluesky Starter Packs. Discover and connect with your community on Bluesky 829117423854
Tom Brett @tombrettlab.bsky.social · 23/11/2024More backyard gardening! First fall veggies! Broccoli and shallots! 140
Reposted by Tom BrettSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 20/11/2024Good write up of BlueSky #MedSky by @kristinafiore.bsky.social feat. BlueSky elders: @mdaware.org @gavinyamey.bsky.social @nickmark.bsky.social @kiswanson.bsky.social and @kidneyboy.bsky.social of course www.medpagetoday.com/special-repo...medpagetoday.comPhysicians Flock to Bluesky, Hoping to Leave X BehindMany compare it to the early days of Twitter 28126
Tom Brett @tombrettlab.bsky.social · 19/11/2024Backyard gardening! Fall crops are getting close to harvest time! Broccoli and cauliflower! 160
Reposted by Tom BrettKaminskiMed @kaminskimed.bsky.social · 18/11/2024This should be mandatory reading for Presidents of Universities and Academic Societies. Also should be printed, framed and hung in their office: "Engage with courage, tenacity, strength and unity. Do NOT obey in advance" #ScienceMatters #NeutralityIsComplicitynature.comScientists must hold President Trump to account with courage and unityDespite many seeing the result as a step backwards, the research community should engage with the new administration with courage, tenacity, strength and unity. 081
Reposted by Tom BrettExtracellular Life @extracellularlife.bsky.social · 18/11/2024Not even sure my alter ego is needed here, but alas, connect the dots as desired. My view on the way to ICU this morning. Hello 🦋 021
Reposted by Tom BrettJen A-Brett @jablab3.bsky.social · 18/11/2024Wow! People are here! A beautiful sky pic to kick it off! 172