Reposted by Dr. Meow
Excited to share my postdoc paper from the @lyons-lab.bsky.social
Our question: what controls axon diameter? It varies >100-fold between neurons, shapes signal speed & myelination, and changes in disease. Yet very little is known about what regulates it. 🧵
journals.plos.org/plosbiology/...
journals.plos.org
A high-resolution phenotypic screen identifies regulators of CNS axon diameter in zebrafish
Axon diameter is important for action potential conduction speed, but what molecular pathways influence this neuronal property? This study reports a high-resolution imaging-based chemical screening pi...