iiinova — where your digital self keeps evolving

Reposted by Timo Denk

Beckmann Lab @beckmannlab.bsky.social · 23/09/2026

Frank Nijpels from VitriMatics paid us a visit today. Not only did he repair our broken VitroBot Mark IV and returned it in person, he also brought some extremely cool tools ❄️ for reliable cryo-EM grid freezing 🔬. Check out the VitriClip and the SupraBlot at vitrimatics.com. #cryoEM #cryoET

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Reposted by Timo Denk

Beckmann Lab @beckmannlab.bsky.social · 14/09/2026

New preprint! 👀RNAse activity has to be tightly regulated.✂️🧬Here, we present the dynamic architecture of the conserved Rixosome complex – a major player in ribosome maturation and heterochromatin maintenance. Our results give insights into its mode of activation.👇 #cryoEM #Ribosome #RNA

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Reposted by Timo Denk

Hauke Hillen @haukehillen.bsky.social · 11/09/2026

Happy to share our new preprint on the structure of the human mitochondrial RNA degradosome, a central player in organellar RNA metabolism! Work led by graduate student @paulafprado.bsky.social in our group. www.biorxiv.org/content/10.6... 🧵 1/9

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Reposted by Timo Denk

Beckmann Lab @beckmannlab.bsky.social · 10/09/2026

📰Happy to share our preprint.🥳Here we investigate🔬, the essential role of the conserved RNA helicase Drs1. We show that its engagement and activity license timely incorporation of 25S rRNA domain III into maturing nucleolar pre-60S subunits.👇 doi.org/10.64898/2026.09.05.749353 #cryoEM #ribosome #RNA

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Reposted by Timo Denk

Hopfner Lab @hopfnerlab.bsky.social · 02/09/2026

🧵 We’re excited to share our new bioRxiv preprint on how INO80 reads promoter-proximal DNA sequence features to position +1 nucleosomes 🧬 Amazing work by Mariia, Annika, and others! 🤩 🔗 www.biorxiv.org/content/10.6... #ChromatinBiology #StructuralBiology #Nucleosome #INO80

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Reposted by Timo Denk

Beckmann Lab @beckmannlab.bsky.social · 01/09/2026

Preprint alert: a helicase watching the ribosomal A-site 👀🧬 Our cryo-EM structure reveals how yeast Dhx29 senses mRNA hairpins forming in the A-site and positions its helicase at the mRNA entry channel to resolve them during translation elongation: doi.org/10.64898/202... #cryoEM #ribosome #RNA

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Reposted by Timo Denk

Tsai-Hsuan Weng @thweng.bsky.social · 15/06/2026

It's finally out now in @natcomms.nature.com! We used cryo-EM + simulations to watch the Na⁺/H⁺ antiporter NhaA in action across a wide range of pH—and uncover how pH, Na⁺ binding, and structural changes are coupled. Read here 🔗 www.nature.com/articles/s41...

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Reposted by Timo Denk

Jean-Paul Armache @valendraica.bsky.social · 14/06/2026

We are sharing a tool developed initially for internal use called VOSE (Volume Operations Simplified Edition) today. It is written specifically to work in ChimeraX (version 1.5+), with no additional libraries necessary to be installed. github.com/jparmachelab...

github.com

GitHub - jparmachelab/ChimeraX-VOSE: ChimeraX Volume Operations Simplified Edition

ChimeraX Volume Operations Simplified Edition . Contribute to jparmachelab/ChimeraX-VOSE development by creating an account on GitHub.

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Reposted by Timo Denk

Beckmann Lab @beckmannlab.bsky.social · 22/03/2026

Proud to share our latest preprint! 🥳 Using a multidisciplinary approach, we uncover a dual function of the snR37 H/ACA snoRNP - combining pseudouridylation with ribosome chaperone activity within a single RNP.🔬🧬 Challenging the traditional view of snoRNP function. 👇 #cryoEM #ribosome #RNA #snoRNA

biorxiv.org

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Ariel Klavaris @arielchk.bsky.social · 21/03/2026

Glad to be part of this great work from @beckmannlab.bsky.social, led by @guan316.bsky.social and @timodenk.bsky.social, exploring the mechanics of co-translational acetylation of histones by NAA40.

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Beckmann Lab @beckmannlab.bsky.social · 16/03/2026

How are histones acetylated as they emerge from the ribosome? We show that NAA40 cooperates with the NAC complex to enable co-translational acetylation of H2A/H4, revealing NAC as a coordinator of nascent protein modification. Read more about our collaboration with @kirmizislab.bsky.social #cryoEM

rdcu.be

NAA40 and NAC cooperate in co-translational histone acetylation in humans

Nature Communications - N-terminal histone acetylation by human NAA40 alters epigenetic signaling and affects gene regulation. Here, the authors combine biochemistry and cryo-EM to unravel the...

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Reposted by Timo Denk

Beckmann Lab @beckmannlab.bsky.social · 23/11/2025

How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4 rdcu.be/eRmJl #ribosome #cryoEM #LMU #JHMI

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Beckmann Lab @beckmannlab.bsky.social · 07/11/2025

🎉Thrilled to share that our lab has been awarded an ERC Synergy Grant @erc.europa.eu! Excited for amazing collaborations with the Pertschy (Uni Graz), Henras (CBI Toulouse), and Woodson (Johns Hopkins) labs. #ERCSyG #GeneCenter #LMU #UniGraz #CNRS #JohnsHopkins

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Beckmann Lab @beckmannlab.bsky.social · 28/05/2025

We are excited to share our collab with @kedrov-lab.bsky.social! Using Cryo-EM❄️ on an amazing sample, we found that YidC is recruited to the back of SecYEG during late-stage substrate insertion —supporting that the "back-of-Sec" route observed in eukaryotes also exists in bacteria 🦠. Check it out👇👇👇

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Reposted by Timo Denk

The EMBO Journal @embojournal.org · 23/05/2025

How does an unusual heptameric AAA-ATPase translocate fully-folded Rieske protein across the inner mitochondrial membrane? Cryo-EM & functional data by Roland Beckmann and coworkers show how Bcs1 alternates between different states during its translocation activity. www.embopress.org/doi/full/10....

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Reposted by Timo Denk

Beckmann Lab @beckmannlab.bsky.social · 26/05/2025

We are happy to share that our snR30 story is finally out in @natureportfolio.nature.com 🥳 We report the first structure of a H/ACA snoRNP acting in ribosome synthesis thereby providing a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇

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