The International Mammalian Synthetic Biology Workshop (mSBW) brings together leaders in synthetic biology with experts from other relevant fields to highlight and inspire cutting-edge synthetic biolo...

Cell Death & Differentiation - Folliculin depletion results in liver cell damage and cholangiocarcinoma through MiT/TFE activation

🎉 We are thrilled to share the success of the latest #HydeParkCoroglio event, featuring our esteemed Prof. Alberto Auricchio, Scientific Director at Tigem in…

AAV-intein-based gene therapy for Stargardt disease proves to be safe and efficacious in large animal models.

D1 receptor agonists bidirectionally regulate working memory capacity (WMC). Here, the authors show that low doses enhance WMC by activating cAMP/PKA in the striatum, whereas high doses impair it via ...

D1 receptor agonists bidirectionally regulate working memory capacity (WMC). Here, the authors show that low doses enhance WMC by activating cAMP/PKA in the striatum, whereas high doses impair it via ...

Mathematical modelling and real-time microfluidics-based measurements of nuclear shuttling dynamics of the transcription factor EB (TFEB) demonstrate its biphasic nature in response to nutrient depriv...

Ferriero et al. show that liver fibrosis reduces the efficiency of AAV-based gene therapy by limiting liver uptake and altering vector distribution to other organs. The impact of fibrosis varies depen...