Abstract. Prostate cancer (PCa) frequently metastasizes to bone, marking incurable disease. This progression is driven by an immunologically cold bone tumor microenvironment that fosters resistance to...

Background People with triple-negative breast cancer (TNBC) typically have poorer survival than those with other breast cancer subtypes, with fewer treatment options available. Type I interferon (IFN)...

Nature Reviews Cancer, Published online: 23 March 2026; doi:10.1038/s41568-026-00915-1Type I interferons (IFNs) critically influence cancer development, progression and therapeutic response. In this Review, Parker, Haynes and colleagues explore the complexity of IFN signalling, with a particular focus on tumour-intrinsic mechanisms, and outline strategies for reprogramming IFN activity in tumours to enhance anticancer immunity and improve patient outcomes.

Type I interferons (IFNs) critically influence cancer development, progression and therapeutic response. In this Review, Parker, Haynes and colleagues explore the complexity of IFN signalling, with a ...

Cancer cells often evade the host immune system, challenging the effectiveness of immunotherapy. In this comprehensive review, Galassi et al. summarize key mechanisms of immune evasion within the “thr...

Here, the authors show that signal transducer and activator of transcription 3 (STAT3) has dual functions in small cell lung cancer as its deletion inhibited primary tumor growth but boosted metastati...

This Review on the interplay between the immune system and metastasis is part of our wider Series of Reviews on Cancer Immunology and Immunotherapy.