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Thomas Agoritsas

@thomasagoritsas.bsky.social
176 followers 118 following 29 posts

⚕️Physician & Prof🇨🇭🇬🇷🇫🇷 Geneva University Hospitals • McMasterU 🇨🇦 • Chair of MagicEvidence.org 🌍 • www.unige.ch/medecine/demed/recherc… • Publications: scholar.google.com/citations?user=u… • Own 🦋

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Thomas Agoritsas @thomasagoritsas.bsky.social · 09/07/2026
Compare the benefits and harms of drugs for obesity in our large network meta-analysis (262 trials including almost 100K patients). Some surprising results, such as as the effects on quality of life at 1 year. Have a look ! 👇
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Thomas Agoritsas @thomasagoritsas.bsky.social · 17/05/2026
Notre invitation, mardi 2 juin aux HUG, pour célébrer une décennie d’initiatives et de projets réalisés à l’hôpital en partenariat avec les patients et patientes. @hug-ge.bsky.social 👉 www.hug.ch/evenement/10... fr.linkedin.com/posts/hopita...
fr.linkedin.com
#partenariat #patients #hôpital #genève | HUG - Hôpitaux Universitaires de Genève
Mardi 2 juin 2026 aux HUG, venez célébrer une décennie d’initiatives et de projets réalisés à l’hôpital en partenariat avec les patients et patientes qui en font l’expérience au quotidien. Un événemen...
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Víctor M Montori MD @vmontori.bsky.social · 13/05/2026
Clinician-in-the-loop: a flawed model for the safe deployment of AI in healthcare. www.bmj.com/content/393/...
bmj.com
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Gordon H. Guyatt @guyattgh.bsky.social · 20/04/2026
Spice-GRADE: methodological breakthrough for #GRADE. New methods showing how indirect evidence from epidemiological investigations of mechanistic causal pathways can complement direct evidence. pubmed.ncbi.nlm.nih.gov/41802581/
pubmed.ncbi.nlm.nih.gov
SPICE-GRADE: simultaneous processing of indirect causal evidence in complex pathways using GRADE - an exploratory case study - PubMed
In this case study, we illustrate SPICE-GRADE as a structured way of mapping and assessing multiple causal links within the GRADE framework. Establishing SPICE-GRADE as a robust methodology for GRADE ...
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MAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 22/03/2026
Closing the gap between research and practice💥 At #REMEDY 2026, Per Olav Vandvik highlighted how MAGIC Evidence Foundation helps turn RCTs into decisions that change care. Evidence is not the endpoint. It is the starting point. Trials → guidelines → implementation → patient decisions. #MAGICevidence
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MAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 14/03/2026
💥New paper from #MAGICevidence community: #SPICEGRADE explores how to assess certainty of the evidence when causal inference relies on chains ⛓️ of indirect evidence. An important step as evidence ecosystems become more complex: www.jclinepi.com/article/S089...
jclinepi.com
SPICE-GRADE: Simultaneous Processing of Indirect Causal Evidence in Complex Pathways Using GRADE -An Exploratory Case Study
Genetic mutations often result in antimicrobial resistance. Early identification of emerging resistance due to genetic mutations often relies on multiple co-existing pathways of indirect evidence. The...
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The BMJ @bmj.com · 27/02/2026
This Rapid Recommendation is a summary of a WHO guideline for influenza www.bmj.com/content/392/...
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The BMJ @bmj.com · 27/02/2026
"The notion that medical research is a 'geopolitical football' is much more than a hypothesis. It is a stark, complex, and miserable reality." @kamranabbasi.bsky.social in Editor's Choice bit.ly/3MBGY4y
bmj.com
From the US to China and India: the power shift in clinical trials
If you’re seeking to keep politics out of medicine, good luck with that. It isn’t possible. We’ve previously described the political determinants of health (doi:10.1136/bmj.h81),1 and next we’ll focus...
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MAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 20/02/2026
Celebrating 10 years of partnership between #MAGICevidence & @bmj.com BMJ Rapid Recs have grown from rapid translation of evidence into 🌏 rigorous, transparent patient-informed guidance, while also serving as a laboratory for innovation. Meeting in London was about celebration & renewed commitment
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BMJ Medicine @bmjmedicine.bsky.social · 17/02/2026
New research📢 Geertruida Bekkering and colleagues compare the effectiveness and safety of pharmacological and non-pharmacological smoking cessation interventions in people with severe mental illness. bit.ly/4kHE8Ye
bit.ly
Smoking cessation for people with severe mental illness: systematic review and network meta-analysis
Objective To evaluate the comparative effectiveness and safety of pharmacological and non-pharmacological smoking cessation interventions in people with severe mental illnessDesign Systematic review a...
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MAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 11/02/2026
MAGICapp was used worldwide in 2025: a shared infrastructure for evidence-based healthcare, supporting real decisions shaped by evidence, patient values, and global collaboration. Grateful to the community translating evidence into practice every day, everywhere.
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BMJ Medicine @bmjmedicine.bsky.social · 13/02/2026
A new Methods Primer by Dan Green and colleagues outlines circumstances where the mean and standard deviation alone are insufficient summary variables, and provides a simple appraisal method for reviewers without raw data Read in BMJ Medicine now: bit.ly/4bJz3w8
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Denis Mongin @denismongin.bsky.social · 26/11/2024
Do people register their #randomizedtrials before starting it ? We studied more than 1000 RCT in #rheumatology to answer this question, to see how it evolved in time and how it varied between RCTs⬇️ Just published in @jclinepi.bsky.social : jclinepi.com/article/S089... #Metaresearch #EpiSky
jclinepi.com
Prospective registration of trials: where we are, why, and how we could get better
Transparent trial conduct requires prospective registration of a randomized controlled clinical trial (RCT) before the enrollment of the first participant. We aimed to (1) estimate the proportion of R...
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Gordon H. Guyatt @guyattgh.bsky.social · 02/02/2026
Latest asked question about Core #GRADE, essence of the GRADE approach to #evidence certainty and moving to #recommendations in #BMJ in 2025. Addresses when and how much to rate down for #imprecision. Joins GRADE for single study and a priori hypotheses explaining #heterogeneity t.co/hh6owWxn5O
t.co
https://www.clarityresearch.ca/frequently-asked-questions
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Thomas Agoritsas @thomasagoritsas.bsky.social · 13/01/2026
Best wishes to all for 2026!
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MAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 12/01/2026
MAGIC’s 2026 priorities: expanding digitally structured guidelines with #MAGICapp, strengthening global capability through education & Core GRADE, advancing BMJ Rapid Recs and applied AI, and connecting the evidence ecosystem to improve real-world impact. Open to collaboration in 2026 💥
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MAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 05/01/2026
[cont.] link to publication: bmjopen.bmj.com/content/15/1... @thomasagoritsas.bsky.social @chrischampion.bsky.social
bmjopen.bmj.com
From international guidelines to practice: a multimethod evaluation of BMJ Rapid Recommendations focusing on suitability for adaptation and implementation
Objectives We aimed to assess usage and explore factors influencing the suitability of British Medical Journal (BMJ) Rapid Recommendations—a set of international guidelines meeting standards of trustw...
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MAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 05/01/2026
Hot off the press from the #MAGICevidence team. New study on how guidelines translate into real-world use, focusing on BMJ Rapid Recs Key message: Methodological rigor builds credibility, but complexity can undermine usability and confidence Implementability needs to be designed, not assumed.
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Gordon H. Guyatt @guyattgh.bsky.social · 02/01/2026
Old photo, guess 2010, recently recovered. The four people responsible for the MAGIC evidence ecosystem foundation – Per Vandvik, Thomas Agoritsas, Linn Brandt and me, along with former Chair of my department for a decade, Brian Haynes, and current Chair Alfonso Iorio. @thomasagoritsas.bsky.social
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Samia Hurst-Majno @samiahurst.bsky.social · 30/12/2025
youtube.com/shorts/zg6AK...
youtube.com
The Geneva Conventions matter more than you may think
YouTube video by Samia Hurst
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MAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 12/11/2025
New in MAGICapp: you can now build Summary of Findings tables for Qualitative Evidence using the GRADE-CERQual framework. A big step toward transparent, structured presentation of qualitative findings in guidelines and evidence syntheses. #MAGICapp #GRADE #CERQual #QualitativeEvidence
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Gordon H. Guyatt @guyattgh.bsky.social · 26/09/2025
At recent #GuidelinesInternationalNetwork (GIN) meeting with Thomas Agoritsas, Chair of the #MAGICEcosytemFoundation and international #GRADE methodology leader and our researcher Prashanti Eachempati, creator of the JUDGE instrument that will revolutionize GRADE education and practice.
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Gordon H. Guyatt @guyattgh.bsky.social · 05/12/2025
Core #GRADE, 7 articles in #BMJ this spring, one-stop-shopping for those who want to get GRADE right with the essentials. Now also frequently asked question – latest post considers a priori hypotheses to explain #heterogeneity. All questions welcome, send to guyatt@mcmaster.ca t.co/hh6owWxn5O
t.co
https://www.clarityresearch.ca/frequently-asked-questions
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Glyn Elwyn BA MD MSc PhD @glynelwyn.bsky.social · 05/11/2025
A situation where this is no equipoise yet shared decision making can be helpful ... bmjpublichealth.bmj.com/content/3/2/...
bmjpublichealth.bmj.com
Decision support tools in the absence of equipoise: the case for vaccination
Public health is in a bind. The goal of the discipline is to protect and improve the public’s overall health so that populations remain as healthy as possible. Public health considers decisions from a...
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Thomas Agoritsas @thomasagoritsas.bsky.social · 04/12/2025
Challenges with medical advice from social media influencers www.bmj.com/content/391/...
bmj.com
Responding to public health challenges of medical advice from social media influencers
Raffael Heiss and colleagues argue that influencers’ medical advice is often shaped by multiple biases and suggest how to reduce the associated risks Social media influencers have become powerful in ...
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The Lancet @thelancet.com · 19/11/2025
Ultra-processed foods – what’s the impact? In a new Lancet Series, experts warn a global rise in #UPFs presents a growing public health threat. Read the evidence & policy recommendations ⬇️ spkl.io/63327AduhR
Part of a Lancet Infographic summarising the findings from the Lancet Series on Ultra-Processed Foods and Human Health.Part of a Lancet Infographic summarising the findings from the Lancet Series on Ultra-Processed Foods and Human Health.Part of a Lancet Infographic summarising the findings from the Lancet Series on Ultra-Processed Foods and Human Health.
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Gordon H. Guyatt @guyattgh.bsky.social · 20/10/2025
Are #RelativeRisks overwhelmingly similar across risk groups? And if so, can we personalize care by applying relative risk to individual patients’ risk profiles? This key #EBM study demonstrates that the answer to both questions is an unquestionable YES. pubmed.ncbi.nlm.nih.gov/11914297/
pubmed.ncbi.nlm.nih.gov
Can we individualize the 'number needed to treat'? An empirical study of summary effect measures in meta-analyses - PubMed
The fixed effects OR, random effects OR and random effects RR appear to be reasonably constant across different baseline risks. Given the interpretational and arithmetic ease of RR, clinicians may wis...
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Gordon H. Guyatt @guyattgh.bsky.social · 03/11/2025
Forming #EvidenceBased plans of #EBM care that respond to each patient’s situation demands #SharedDecisionMaking. JP Brito, Iris Hargraves, and Marleen Kunneman are doing leading work to advance the practice of making care fit using shared decision making. ebm.bmj.com/content/28/4...
ebm.bmj.com
Shared decision-making as a method of care
Care happens in interaction between the patient and the clinician, in conversation where the patient and clinician uncover or develop a shared understanding of the problematic situation of the patient...
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Thomas Agoritsas @thomasagoritsas.bsky.social · 12/10/2025
🚨⚕️Enhancing clinical encounters: our new systematic review on how hospitals’ institutional programs could protect or increase the time dedicated to interactions. It included 117 unique studies comprising 298,517 patients 👇 link.springer.com/article/10.1...
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Thomas Agoritsas @thomasagoritsas.bsky.social · 13/11/2025
L'UE examine l'Initiative citoyenne européenne (ICE) visant à interdire les "thérapies de conversion" dans toute l'Europe. Les prochains mois sont essentiels – assurons-nous qu'elle agisse. J'ai signé. Rejoignez-moi 👉 a.allout.org/s/OJyE5/
a.allout.org
Interdisons les « thérapies de conversion » dans l’UE !
L’UE examine l’Initiative citoyenne européenne (ICE) visant à interdire les “thérapies de conversion” dans toute l’Europe. Les prochains mois seront décisifs : agiront-ils vraiment ou détourneront-ils...
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MAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 06/11/2025
They founded MAGIC over ten years ago to improve how evidence is generated, translated, and used in clinical decisions. The goal was clear: more transparency, more trust, better patient care. Inspiring to see what it has become. 📸: Per Vandvik & @thomasagoritsas.bsky.social
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Gordon H. Guyatt @guyattgh.bsky.social · 22/10/2025
15 minute #JAMA podcast in which I interview world authority @thomasagoritsas.bsky.social on how to Use a Patient Management #Recommendations: #ClinicalPracticeGuidelines and #DecisionAnalyses edhub.ama-assn.org/jn-learning/...
edhub.ama-assn.org
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MAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 22/10/2025
A #MAGICal conversation between @guyattgh.bsky.social , MAGIC's lead methodologist, and @thomasagoritsas.bsky.social , MAGIC's Board Chair, featured in JAMA Network learning podcast 💥 on #CPG and decision analyses Don't miss that out! edhub.ama-assn.org/jn-learning/...
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MAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 06/10/2025
At MAGIC, transformation doesn’t come from a single innovation — it comes from innovation + connection. 🔹 MAGICapp: digital infrastructure for living guidance 🔹 Turning evidence into action 🔹 Making sure guidance is used, not just published 📅 See MAGICapp in action → wkf.ms/3W17lBN
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MAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 16/10/2025
Are you developing clinical practice guidelines? At MAGIC, we’re building tools and collaborations to make evidence-based guidelines more trustworthy and dynamic. If your team is working on guidelines, we invite you to get to know MAGIC & MAGICapp Get in touch: forms.monday.com/forms/baaf06...
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MAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 08/10/2025
At MAGIC, we turn the best evidence into trustworthy guidance to improve patient care. 💡 #MAGICapp powers this process — a digital platform to build, publish, and update clinical practice #guidelines. 😎 Backed by a global network of leading methodologists. magicevidence.org
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MAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 17/10/2025
Still using Word and PDFs for guidelines 💥 ? In 2025, there’s a better way 🤩 #MAGICapp helps teams move from clunky documents to structured, collaborative guidelines: Curious if it’s right for you? 👉 Book a demo to learn more: forms.monday.com/forms/baaf06...
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WHO @who.int · 14/10/2025
1 in 3 people is living with neurological condition, such as stroke, epilepsy, migraine, autism. Despite the number of people with these conditions, those in low- and middle- income countries face the greatest challenges bit.ly/4oj81yH
Over 3 billon people live with neurological disorders
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Thomas Agoritsas @thomasagoritsas.bsky.social · 12/10/2025
🚨⚕️Enhancing clinical encounters: our new systematic review on how hospitals’ institutional programs could protect or increase the time dedicated to interactions. It included 117 unique studies comprising 298,517 patients 👇 link.springer.com/article/10.1...
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The BMJ @bmj.com · 09/10/2025
"Moving beyond the uncomfortable apathy of medical neutrality is the duty of professionals and their organisations." Where genocide, healthocide, and atrocities start, medical neutrality ends, says @kamranabbasi.bsky.social in this Editor's Choice www.bmj.com/content/391/...
Image showing people clearing a bomb site in Gaza
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Kamran Abbasi @kamranabbasi.bsky.social · 07/10/2025
“One factor is denial. Those responsible for genocide do not admit to their plans. Allies support their denials. Declassified documents show that US, French, and Belgian officials knew that genocide was occurring in Rwanda and avoided taking action” @bmj.com www.bmj.com/content/391/...
bmj.com
Testimony, advocacy, and the public health effect of genocide
Medical community must play its part in ending atrocities In 2000, JAMA published a commentary by Willis and Levy calling for action to ensure recognition of the public health impact of genocide.1 Th...
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EMRE KIZILKAYA @emrekizilkaya.bsky.social · 01/10/2025
A great discussion paper by Montori et al. for @harvard-carr-ryan.bsky.social. They warn that surveillance capitalism is reshaping healthcare into a system focused on data rather than people, enabling Big Tech to commodify human experience and consolidate power: www.hks.harvard.edu/centers/carr...
hks.harvard.edu
The Un-Mattering of People: The Present and Near-Future of Surveillance Capitalism and the Fate of Care in Healthcare
The encroachment of surveillance capitalism into healthcare takes place as healthcare becomes increasingly industrialized.
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Eric Topol @erictopol.bsky.social · 28/09/2025
More than 2 decades since GLP-1 drugs were introduced, we still don't know why people with diabetes lose about half as much weight as those without diabetes at the same dose nature.com/articles/s41...
nature.com
Effects of tirzepatide on weight management in patients with and without diabetes: a systematic review and meta-analysis - International Journal of Obesity
International Journal of Obesity - Effects of tirzepatide on weight management in patients with and without diabetes: a systematic review and meta-analysis
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Robert Reich @rbreich.bsky.social · 24/09/2025
The richest man on earth owns X. The second richest man on earth is about to be a major owner of TikTok. The third richest man owns Facebook, Instagram, and WhatsApp. The fourth richest man owns The Washington Post. See the problem here?
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Thomas Agoritsas @thomasagoritsas.bsky.social · 24/09/2025
“Loosing the information war? - Get off social media - Read good books & real journalism - Find your friends - And enjoy your life.” samharris.substack.com/p/we-are-los...
samharris.substack.com
We Are Losing the Information War with Ourselves
If the medium is the message, the message is mass psychosis.
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MAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 24/09/2025
5 problems in guideline development — solved with #MAGICapp 😎 ✅ Simpler workflow ✅ Real-time collaboration ✅ Always up to date 🔗 Book a demo: forms.monday.com/forms/baaf06... @thomasagoritsas.bsky.social @chrischampion.bsky.social
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BMJ Medicine @bmjmedicine.bsky.social · 22/09/2025
How effective are de-implementation strategies to reduce low value care? Aleksi Raudasoja and colleagues conducted a systematic review and meta analysis to find out. 🧵
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Víctor M Montori MD @vmontori.bsky.social · 20/09/2025
Distinguishing the Difference Between Curing and Caring When Treating Patients | NEJM Catalyst catalyst.nejm.org/doi/full/10.... @patientrevolution.org
catalyst.nejm.org
Distinguishing the Difference Between Curing and Caring When Treating Patients
Dr. Victor Montori, MD, MSc, Robert H. and Susan M. Rewoldt Professor of Medicine and leader of the Knowledge and Evaluation Research (KER) Unit at the Mayo Clinic and Co-Founder of The Patient Rev...
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Thomas Agoritsas @thomasagoritsas.bsky.social · 19/09/2025
Strategic meetings beteeen MAGIC and WHO to support their clinical practice guidelines @magicevidence.bsky.social @chrischampion.bsky.social
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MAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 19/09/2025
Operationalizing trustworthy #AI for #GRADE: JUDGE turns tacit rating-down into 25 teachable prompts. SMART-GRADE uses #LLMs + human-in-the-loop for traceable summaries. Next: expand use cases + benchmarks with guideline panels. #GIN2025 @thomasagoritsas.bsky.social @guyattgh.bsky.social
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