Thomas Agoritsas @thomasagoritsas.bsky.social · 09/07/2026Compare the benefits and harms of drugs for obesity in our large network meta-analysis (262 trials including almost 100K patients). Some surprising results, such as as the effects on quality of life at 1 year. Have a look ! 👇 010
Thomas Agoritsas @thomasagoritsas.bsky.social · 17/05/2026Notre invitation, mardi 2 juin aux HUG, pour célébrer une décennie d’initiatives et de projets réalisés à l’hôpital en partenariat avec les patients et patientes. @hug-ge.bsky.social 👉 www.hug.ch/evenement/10... fr.linkedin.com/posts/hopita...fr.linkedin.com#partenariat #patients #hôpital #genève | HUG - Hôpitaux Universitaires de GenèveMardi 2 juin 2026 aux HUG, venez célébrer une décennie d’initiatives et de projets réalisés à l’hôpital en partenariat avec les patients et patientes qui en font l’expérience au quotidien. Un événemen... 000
Reposted by Thomas AgoritsasVíctor M Montori MD @vmontori.bsky.social · 13/05/2026Clinician-in-the-loop: a flawed model for the safe deployment of AI in healthcare. www.bmj.com/content/393/...bmj.com 1102
Reposted by Thomas AgoritsasGordon H. Guyatt @guyattgh.bsky.social · 20/04/2026Spice-GRADE: methodological breakthrough for #GRADE. New methods showing how indirect evidence from epidemiological investigations of mechanistic causal pathways can complement direct evidence. pubmed.ncbi.nlm.nih.gov/41802581/pubmed.ncbi.nlm.nih.govSPICE-GRADE: simultaneous processing of indirect causal evidence in complex pathways using GRADE - an exploratory case study - PubMedIn this case study, we illustrate SPICE-GRADE as a structured way of mapping and assessing multiple causal links within the GRADE framework. Establishing SPICE-GRADE as a robust methodology for GRADE ... 021
Reposted by Thomas AgoritsasMAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 22/03/2026Closing the gap between research and practice💥 At #REMEDY 2026, Per Olav Vandvik highlighted how MAGIC Evidence Foundation helps turn RCTs into decisions that change care. Evidence is not the endpoint. It is the starting point. Trials → guidelines → implementation → patient decisions. #MAGICevidence 011
Reposted by Thomas AgoritsasMAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 14/03/2026💥New paper from #MAGICevidence community: #SPICEGRADE explores how to assess certainty of the evidence when causal inference relies on chains ⛓️ of indirect evidence. An important step as evidence ecosystems become more complex: www.jclinepi.com/article/S089...jclinepi.comSPICE-GRADE: Simultaneous Processing of Indirect Causal Evidence in Complex Pathways Using GRADE -An Exploratory Case StudyGenetic mutations often result in antimicrobial resistance. Early identification of emerging resistance due to genetic mutations often relies on multiple co-existing pathways of indirect evidence. The... 021
Reposted by Thomas AgoritsasThe BMJ @bmj.com · 27/02/2026This Rapid Recommendation is a summary of a WHO guideline for influenza www.bmj.com/content/392/... 1167
Reposted by Thomas AgoritsasThe BMJ @bmj.com · 27/02/2026"The notion that medical research is a 'geopolitical football' is much more than a hypothesis. It is a stark, complex, and miserable reality." @kamranabbasi.bsky.social in Editor's Choice bit.ly/3MBGY4ybmj.comFrom the US to China and India: the power shift in clinical trialsIf you’re seeking to keep politics out of medicine, good luck with that. It isn’t possible. We’ve previously described the political determinants of health (doi:10.1136/bmj.h81),1 and next we’ll focus... 083
Reposted by Thomas AgoritsasMAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 20/02/2026Celebrating 10 years of partnership between #MAGICevidence & @bmj.com BMJ Rapid Recs have grown from rapid translation of evidence into 🌏 rigorous, transparent patient-informed guidance, while also serving as a laboratory for innovation. Meeting in London was about celebration & renewed commitment 032
Reposted by Thomas AgoritsasBMJ Medicine @bmjmedicine.bsky.social · 17/02/2026New research📢 Geertruida Bekkering and colleagues compare the effectiveness and safety of pharmacological and non-pharmacological smoking cessation interventions in people with severe mental illness. bit.ly/4kHE8Ye bit.lySmoking cessation for people with severe mental illness: systematic review and network meta-analysisObjective To evaluate the comparative effectiveness and safety of pharmacological and non-pharmacological smoking cessation interventions in people with severe mental illnessDesign Systematic review a... 031
Reposted by Thomas AgoritsasMAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 11/02/2026MAGICapp was used worldwide in 2025: a shared infrastructure for evidence-based healthcare, supporting real decisions shaped by evidence, patient values, and global collaboration. Grateful to the community translating evidence into practice every day, everywhere. 011
Reposted by Thomas AgoritsasBMJ Medicine @bmjmedicine.bsky.social · 13/02/2026A new Methods Primer by Dan Green and colleagues outlines circumstances where the mean and standard deviation alone are insufficient summary variables, and provides a simple appraisal method for reviewers without raw data Read in BMJ Medicine now: bit.ly/4bJz3w8 032
Reposted by Thomas AgoritsasDenis Mongin @denismongin.bsky.social · 26/11/2024Do people register their #randomizedtrials before starting it ? We studied more than 1000 RCT in #rheumatology to answer this question, to see how it evolved in time and how it varied between RCTs⬇️ Just published in @jclinepi.bsky.social : jclinepi.com/article/S089... #Metaresearch #EpiSkyjclinepi.comProspective registration of trials: where we are, why, and how we could get betterTransparent trial conduct requires prospective registration of a randomized controlled clinical trial (RCT) before the enrollment of the first participant. We aimed to (1) estimate the proportion of R... 22510
Reposted by Thomas AgoritsasGordon H. Guyatt @guyattgh.bsky.social · 02/02/2026Latest asked question about Core #GRADE, essence of the GRADE approach to #evidence certainty and moving to #recommendations in #BMJ in 2025. Addresses when and how much to rate down for #imprecision. Joins GRADE for single study and a priori hypotheses explaining #heterogeneity t.co/hh6owWxn5Ot.cohttps://www.clarityresearch.ca/frequently-asked-questions 011
Reposted by Thomas AgoritsasMAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 12/01/2026MAGIC’s 2026 priorities: expanding digitally structured guidelines with #MAGICapp, strengthening global capability through education & Core GRADE, advancing BMJ Rapid Recs and applied AI, and connecting the evidence ecosystem to improve real-world impact. Open to collaboration in 2026 💥 021
Reposted by Thomas AgoritsasMAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 05/01/2026[cont.] link to publication: bmjopen.bmj.com/content/15/1... @thomasagoritsas.bsky.social @chrischampion.bsky.socialbmjopen.bmj.comFrom international guidelines to practice: a multimethod evaluation of BMJ Rapid Recommendations focusing on suitability for adaptation and implementationObjectives We aimed to assess usage and explore factors influencing the suitability of British Medical Journal (BMJ) Rapid Recommendations—a set of international guidelines meeting standards of trustw... 011
Reposted by Thomas AgoritsasMAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 05/01/2026Hot off the press from the #MAGICevidence team. New study on how guidelines translate into real-world use, focusing on BMJ Rapid Recs Key message: Methodological rigor builds credibility, but complexity can undermine usability and confidence Implementability needs to be designed, not assumed. 131
Reposted by Thomas AgoritsasGordon H. Guyatt @guyattgh.bsky.social · 02/01/2026Old photo, guess 2010, recently recovered. The four people responsible for the MAGIC evidence ecosystem foundation – Per Vandvik, Thomas Agoritsas, Linn Brandt and me, along with former Chair of my department for a decade, Brian Haynes, and current Chair Alfonso Iorio. @thomasagoritsas.bsky.social 011
Reposted by Thomas AgoritsasSamia Hurst-Majno @samiahurst.bsky.social · 30/12/2025youtube.com/shorts/zg6AK...youtube.comThe Geneva Conventions matter more than you may thinkYouTube video by Samia Hurst 043
Reposted by Thomas AgoritsasMAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 12/11/2025New in MAGICapp: you can now build Summary of Findings tables for Qualitative Evidence using the GRADE-CERQual framework. A big step toward transparent, structured presentation of qualitative findings in guidelines and evidence syntheses. #MAGICapp #GRADE #CERQual #QualitativeEvidence 001
Reposted by Thomas AgoritsasGordon H. Guyatt @guyattgh.bsky.social · 26/09/2025At recent #GuidelinesInternationalNetwork (GIN) meeting with Thomas Agoritsas, Chair of the #MAGICEcosytemFoundation and international #GRADE methodology leader and our researcher Prashanti Eachempati, creator of the JUDGE instrument that will revolutionize GRADE education and practice. 011
Reposted by Thomas AgoritsasGordon H. Guyatt @guyattgh.bsky.social · 05/12/2025Core #GRADE, 7 articles in #BMJ this spring, one-stop-shopping for those who want to get GRADE right with the essentials. Now also frequently asked question – latest post considers a priori hypotheses to explain #heterogeneity. All questions welcome, send to guyatt@mcmaster.ca t.co/hh6owWxn5Ot.cohttps://www.clarityresearch.ca/frequently-asked-questions 011
Reposted by Thomas AgoritsasGlyn Elwyn BA MD MSc PhD @glynelwyn.bsky.social · 05/11/2025A situation where this is no equipoise yet shared decision making can be helpful ... bmjpublichealth.bmj.com/content/3/2/...bmjpublichealth.bmj.comDecision support tools in the absence of equipoise: the case for vaccinationPublic health is in a bind. The goal of the discipline is to protect and improve the public’s overall health so that populations remain as healthy as possible. Public health considers decisions from a... 041
Thomas Agoritsas @thomasagoritsas.bsky.social · 04/12/2025Challenges with medical advice from social media influencers www.bmj.com/content/391/...bmj.comResponding to public health challenges of medical advice from social media influencersRaffael Heiss and colleagues argue that influencers’ medical advice is often shaped by multiple biases and suggest how to reduce the associated risks Social media influencers have become powerful in ... 010
Reposted by Thomas AgoritsasThe Lancet @thelancet.com · 19/11/2025Ultra-processed foods – what’s the impact? In a new Lancet Series, experts warn a global rise in #UPFs presents a growing public health threat. Read the evidence & policy recommendations ⬇️ spkl.io/63327AduhR 35433
Reposted by Thomas AgoritsasGordon H. Guyatt @guyattgh.bsky.social · 20/10/2025Are #RelativeRisks overwhelmingly similar across risk groups? And if so, can we personalize care by applying relative risk to individual patients’ risk profiles? This key #EBM study demonstrates that the answer to both questions is an unquestionable YES. pubmed.ncbi.nlm.nih.gov/11914297/pubmed.ncbi.nlm.nih.govCan we individualize the 'number needed to treat'? An empirical study of summary effect measures in meta-analyses - PubMedThe fixed effects OR, random effects OR and random effects RR appear to be reasonably constant across different baseline risks. Given the interpretational and arithmetic ease of RR, clinicians may wis... 011
Reposted by Thomas AgoritsasGordon H. Guyatt @guyattgh.bsky.social · 03/11/2025Forming #EvidenceBased plans of #EBM care that respond to each patient’s situation demands #SharedDecisionMaking. JP Brito, Iris Hargraves, and Marleen Kunneman are doing leading work to advance the practice of making care fit using shared decision making. ebm.bmj.com/content/28/4...ebm.bmj.comShared decision-making as a method of careCare happens in interaction between the patient and the clinician, in conversation where the patient and clinician uncover or develop a shared understanding of the problematic situation of the patient... 021
Reposted by Thomas AgoritsasThomas Agoritsas @thomasagoritsas.bsky.social · 12/10/2025🚨⚕️Enhancing clinical encounters: our new systematic review on how hospitals’ institutional programs could protect or increase the time dedicated to interactions. It included 117 unique studies comprising 298,517 patients 👇 link.springer.com/article/10.1... 021
Thomas Agoritsas @thomasagoritsas.bsky.social · 13/11/2025L'UE examine l'Initiative citoyenne européenne (ICE) visant à interdire les "thérapies de conversion" dans toute l'Europe. Les prochains mois sont essentiels – assurons-nous qu'elle agisse. J'ai signé. Rejoignez-moi 👉 a.allout.org/s/OJyE5/a.allout.orgInterdisons les « thérapies de conversion » dans l’UE !L’UE examine l’Initiative citoyenne européenne (ICE) visant à interdire les “thérapies de conversion” dans toute l’Europe. Les prochains mois seront décisifs : agiront-ils vraiment ou détourneront-ils... 010
Reposted by Thomas AgoritsasMAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 06/11/2025They founded MAGIC over ten years ago to improve how evidence is generated, translated, and used in clinical decisions. The goal was clear: more transparency, more trust, better patient care. Inspiring to see what it has become. 📸: Per Vandvik & @thomasagoritsas.bsky.social 011
Reposted by Thomas AgoritsasGordon H. Guyatt @guyattgh.bsky.social · 22/10/202515 minute #JAMA podcast in which I interview world authority @thomasagoritsas.bsky.social on how to Use a Patient Management #Recommendations: #ClinicalPracticeGuidelines and #DecisionAnalyses edhub.ama-assn.org/jn-learning/...edhub.ama-assn.org 011
Reposted by Thomas AgoritsasMAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 22/10/2025A #MAGICal conversation between @guyattgh.bsky.social , MAGIC's lead methodologist, and @thomasagoritsas.bsky.social , MAGIC's Board Chair, featured in JAMA Network learning podcast 💥 on #CPG and decision analyses Don't miss that out! edhub.ama-assn.org/jn-learning/... 011
Reposted by Thomas AgoritsasMAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 06/10/2025At MAGIC, transformation doesn’t come from a single innovation — it comes from innovation + connection. 🔹 MAGICapp: digital infrastructure for living guidance 🔹 Turning evidence into action 🔹 Making sure guidance is used, not just published 📅 See MAGICapp in action → wkf.ms/3W17lBN 011
Reposted by Thomas AgoritsasMAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 16/10/2025Are you developing clinical practice guidelines? At MAGIC, we’re building tools and collaborations to make evidence-based guidelines more trustworthy and dynamic. If your team is working on guidelines, we invite you to get to know MAGIC & MAGICapp Get in touch: forms.monday.com/forms/baaf06... 011
Reposted by Thomas AgoritsasMAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 08/10/2025At MAGIC, we turn the best evidence into trustworthy guidance to improve patient care. 💡 #MAGICapp powers this process — a digital platform to build, publish, and update clinical practice #guidelines. 😎 Backed by a global network of leading methodologists. magicevidence.org 032
Reposted by Thomas AgoritsasMAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 17/10/2025Still using Word and PDFs for guidelines 💥 ? In 2025, there’s a better way 🤩 #MAGICapp helps teams move from clunky documents to structured, collaborative guidelines: Curious if it’s right for you? 👉 Book a demo to learn more: forms.monday.com/forms/baaf06... 011
Reposted by Thomas AgoritsasWHO @who.int · 14/10/20251 in 3 people is living with neurological condition, such as stroke, epilepsy, migraine, autism. Despite the number of people with these conditions, those in low- and middle- income countries face the greatest challenges bit.ly/4oj81yH 011335
Thomas Agoritsas @thomasagoritsas.bsky.social · 12/10/2025🚨⚕️Enhancing clinical encounters: our new systematic review on how hospitals’ institutional programs could protect or increase the time dedicated to interactions. It included 117 unique studies comprising 298,517 patients 👇 link.springer.com/article/10.1... 021
Reposted by Thomas AgoritsasThe BMJ @bmj.com · 09/10/2025"Moving beyond the uncomfortable apathy of medical neutrality is the duty of professionals and their organisations." Where genocide, healthocide, and atrocities start, medical neutrality ends, says @kamranabbasi.bsky.social in this Editor's Choice www.bmj.com/content/391/... 0117
Reposted by Thomas AgoritsasKamran Abbasi @kamranabbasi.bsky.social · 07/10/2025“One factor is denial. Those responsible for genocide do not admit to their plans. Allies support their denials. Declassified documents show that US, French, and Belgian officials knew that genocide was occurring in Rwanda and avoided taking action” @bmj.com www.bmj.com/content/391/...bmj.comTestimony, advocacy, and the public health effect of genocideMedical community must play its part in ending atrocities In 2000, JAMA published a commentary by Willis and Levy calling for action to ensure recognition of the public health impact of genocide.1 Th... 131
Reposted by Thomas AgoritsasEMRE KIZILKAYA @emrekizilkaya.bsky.social · 01/10/2025A great discussion paper by Montori et al. for @harvard-carr-ryan.bsky.social. They warn that surveillance capitalism is reshaping healthcare into a system focused on data rather than people, enabling Big Tech to commodify human experience and consolidate power: www.hks.harvard.edu/centers/carr...hks.harvard.eduThe Un-Mattering of People: The Present and Near-Future of Surveillance Capitalism and the Fate of Care in HealthcareThe encroachment of surveillance capitalism into healthcare takes place as healthcare becomes increasingly industrialized. 182
Reposted by Thomas AgoritsasEric Topol @erictopol.bsky.social · 28/09/2025More than 2 decades since GLP-1 drugs were introduced, we still don't know why people with diabetes lose about half as much weight as those without diabetes at the same dose nature.com/articles/s41...nature.comEffects of tirzepatide on weight management in patients with and without diabetes: a systematic review and meta-analysis - International Journal of ObesityInternational Journal of Obesity - Effects of tirzepatide on weight management in patients with and without diabetes: a systematic review and meta-analysis 716132
Reposted by Thomas AgoritsasRobert Reich @rbreich.bsky.social · 24/09/2025The richest man on earth owns X. The second richest man on earth is about to be a major owner of TikTok. The third richest man owns Facebook, Instagram, and WhatsApp. The fourth richest man owns The Washington Post. See the problem here? 18005697019249
Thomas Agoritsas @thomasagoritsas.bsky.social · 24/09/2025“Loosing the information war? - Get off social media - Read good books & real journalism - Find your friends - And enjoy your life.” samharris.substack.com/p/we-are-los...samharris.substack.comWe Are Losing the Information War with OurselvesIf the medium is the message, the message is mass psychosis. 020
Reposted by Thomas AgoritsasMAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 24/09/20255 problems in guideline development — solved with #MAGICapp 😎 ✅ Simpler workflow ✅ Real-time collaboration ✅ Always up to date 🔗 Book a demo: forms.monday.com/forms/baaf06... @thomasagoritsas.bsky.social @chrischampion.bsky.social 012
Reposted by Thomas AgoritsasBMJ Medicine @bmjmedicine.bsky.social · 22/09/2025How effective are de-implementation strategies to reduce low value care? Aleksi Raudasoja and colleagues conducted a systematic review and meta analysis to find out. 🧵 112
Reposted by Thomas AgoritsasVíctor M Montori MD @vmontori.bsky.social · 20/09/2025Distinguishing the Difference Between Curing and Caring When Treating Patients | NEJM Catalyst catalyst.nejm.org/doi/full/10.... @patientrevolution.orgcatalyst.nejm.orgDistinguishing the Difference Between Curing and Caring When Treating PatientsDr. Victor Montori, MD, MSc, Robert H. and Susan M. Rewoldt Professor of Medicine and leader of the Knowledge and Evaluation Research (KER) Unit at the Mayo Clinic and Co-Founder of The Patient Rev... 0131
Thomas Agoritsas @thomasagoritsas.bsky.social · 19/09/2025Strategic meetings beteeen MAGIC and WHO to support their clinical practice guidelines @magicevidence.bsky.social @chrischampion.bsky.social 041
Reposted by Thomas AgoritsasMAGIC Evidence Ecosystem Foundation @magicevidence.bsky.social · 19/09/2025Operationalizing trustworthy #AI for #GRADE: JUDGE turns tacit rating-down into 25 teachable prompts. SMART-GRADE uses #LLMs + human-in-the-loop for traceable summaries. Next: expand use cases + benchmarks with guideline panels. #GIN2025 @thomasagoritsas.bsky.social @guyattgh.bsky.social 011