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One platform for the entire evidence synthesis pipeline. Screening → NMA → GRADE → manuscript. AI-assisted, researcher-controlled.

Early formulations of evidence-based medicine and healthcare emphasised the ability of health professionals to formulate questions, search for and critically appraise individual studies to inform thei...

Over a 15 year period, all screening strategies may reduce colorectal cancer mortality to a similar extent. Colonoscopy and sigmoidoscopy may also reduce colorectal cancer incidence, while FIT shows a...

Public policy and health in the Trump era

While providing at least similar levels of understanding for some items and increased understanding for others, users prefer the new format of SoF tables.

Guidelines should consider clinicians' time needed to treat

Whether a clinical prediction model's AUROC is "good" cannot be judged in isolation. Clinical usefulness arises from the joint relationship between discrimination, outcome incidence, and decision thre...

Conventional translation strategies are limited because they enshrine deficiencies of the original questionnaire and do not permit modifications that reflect differences in culture and values. An alte...

We found that there is no consensus on the definition of ITT in relation to MOD. For conceptual clarity, we suggest that both reports of randomized trials and systematic reviews separately consider an...

The methods by HH, CS, FU and SU are suitable to convert summary treatment effects calculated from continuous outcomes into odds ratios of treatment response and NNTs, whereas the method by KK is unsu...

Presentation of relative effects regarding pain will facilitate interpretation of treatment effects.

The methods by HH, CS, FU and SU are suitable to convert summary treatment effects calculated from continuous outcomes into odds ratios of treatment response and NNTs, whereas the method by KK is unsu...

This work aims to help methodologists in review teams, technology assessors, guideline panelists, and anyone conducting evidence syntheses using GRADE.

A guide and pragmatic considerations for applying GRADE to network meta-analysis

In the first article of this series, we reviewed the basic genetics concepts necessary to understand genetic association studies. In this second article, we enumerate the major issues in judging the v...

Tips for learners of evidence-based medicine: 4. Assessing heterogeneity of primary studies in systematic reviews and whether to combine their results

This study will develop standard materials for surveying patient values and determining MIDs in Chinese CAD patients. The resulting methodology will support future investigations into patient-importan...

Many medical guidelines say that they use a trusted scientific method called GRADE to make their advice reliable. But we neither know if they actually follow it correctly nor were there good tools to ...

Users' guides to the medical literature: XVII. How to use guidelines and recommendations about screening. Evidence-Based Medicine Working Group

We failed to find a significant association between PFS and HRQoL in cancer clinical trials. These findings raise questions regarding the assumption that interventions prolonging PFS also improve HRQo...

This cross-sectional study evaluates the end-to-end clinical reasoning ability of off-the-shelf large language models using standardized clinical vignettes and introduces a multidimensional comprehens...

GRADE approach to drawing conclusions from a network meta-analysis using a minimally contextualised framework

In this case study, we illustrate SPICE-GRADE as a structured way of mapping and assessing multiple causal links within the GRADE framework. Establishing SPICE-GRADE as a robust methodology for GRADE ...

Instruments that are useful in clinical or research practice will, when the object of measurement is stable, yield similar results when applied at different times, in different situations, or by diffe...

When advising patients on the optimal duration of anticoagulation for venous thromboembolism (VTE), current management often relies on the intuition of treating physicians and guideline panels, an app...

In this systematic review we looked for the long-term effects of childbirth on urinary leakage. We found that vaginal delivery is associated with an almost twofold increase in the risk of developing l...

The purpose of this study was to compare the performance of measures of health-related quality of life in a randomized controlled trial of respiratory rehabilitation versus conventional community care...

CLARITY represents the formal alliance of a group of researchers who have enjoyed a long-standing and fruitful collaboration. Through formal collaboration, Clarity's clinical advances through research...

When direct and indirect estimates of treatment effects are coherent, network meta-analysis (NMA) estimates should have increased precision (narrower confidence or credible intervals compared with relying on direct estimates alone), a benefit of NMA. We have, however, observed cases of sparse networ …

Observational studies almost always have bias because prognostic factors are unequally distributed between patients exposed or not exposed to an intervention. The standard approach to dealing with this problem is adjusted or stratified analysis. Its principle is to use measurement of risk factors to …

Tips for learners of evidence-based medicine: 1. Relative risk reduction, absolute risk reduction and number needed to treat

A decision algorithm for assessing indirectness in core GRADE

This article presents official guidance from the Grading of Recommendations Assessments, Development, and Evaluation (GRADE) working group on how to address incoherence when assessing the certainty in the evidence from network meta-analysis. Incoherence represents important differences between direc …

With the possible exception of blinding of data analysts, use of "probably yes" and "probably no" instead of "unclear" may enhance the assessment of blinding in trials.

CLARITY represents the formal alliance of a group of researchers who have enjoyed a long-standing and fruitful collaboration. Through formal collaboration, Clarity's clinical advances through research...