iiinova — where your digital self keeps evolving

Theresa Zeisner @theresazeisner.bsky.social · 05/08/2026

So happy the Klimt-fish made it across the Atlantic! 🐠

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Theresa Zeisner @theresazeisner.bsky.social · 16/07/2026

Best feeling, when your conference Tshirt design makes it out into the wild 🤩🐠

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Theresa Zeisner @theresazeisner.bsky.social · 16/07/2026

Super happy you like it! Would fit great into the office decor 🐠

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Reposted by Theresa Zeisner

Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 07/07/2026

The #EZM2026 (European Zebrafish Society @ezsociety.bsky.social meeting) is in full swing! More than 500 (not only zebra-)fish researchers from all over the world gather here in Vienna for the next 5 days to discuss science, exchange ideas and make new connections. #Fish #Zebrafish #Friends

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Kristina Stapornwongkul @kstapornwongkul.bsky.social · 27/05/2026

You're a devbio and stem cell enthusiast in Vienna? Come meet the community at #DevStem26 @istaresearch.bsky.social on June 16th! Only 3 days left to register & submit your abstract! Free registration 👇 devstem.pages.ist.ac.at

devstem.pages.ist.ac.at

Development and Stem Cells Regional Meeting

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Theresa Zeisner @theresazeisner.bsky.social · 22/04/2026

Want to find out how a zebrafish develops from a small ball of cells into a functioning organism? 🐠 Then join us at the microscopes this Friday at @viennabiocenter.bsky.social for the Long Night of Research 🔬👩‍🔬 langenachtderforschung.at/station/592 📍Vienna BioCenter, 1030 Wien ⏰ 17:00-23:00

langenachtderforschung.at

Wie entwickelt sich ein Fisch? - #LNF26 Lange Nacht der Forschung

Wie schafft es der Zebrafisch sich binnen eines Tages aus einem Zellhaufen zu einem schwimmenden Fisch zu entwickeln? Beobachten Sie mit Hilfe eines Mikroskops, wie Zebrafische wachsen und finden Sie ...

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Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · 02/03/2026

The new Vienna BioCenter Interdisciplinary Postdoctoral Program (VIP³) is here! We have 8 fully-funded positions for scientists with a PhD in biology, chemistry, physics, bioinformatics etc. The call is open! More information: training.vbc.ac.at/post-docs/vi... #VBCPostDoc

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Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · 01/03/2026

The Vienna BioCenter PhD program in Molecular BioSciences will offer 25+ fully-funded positions in the Spring Call which is now open. Have a look at our campus: www.vbcphd.at Institute of Molecular Biotechnology, Max Perutz Labs Vienna, IMP, Gregor Mendel Institute of Molecular Plant Biology

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The Francis Crick Institute @crick.ac.uk · 18/02/2026

Motivated graduates with backgrounds in biological or biomedical sciences, physics, chemistry, mathematics, engineering and/or computer science are invited to apply to our 4-year fully funded PhD programme. Apply by 17 March 2026. www.crick.ac.uk/careers-stud...

crick.ac.uk

PhD student recruitment

PhD recruitment information.

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Kristina Stapornwongkul @kstapornwongkul.bsky.social · 17/02/2026

We‘re looking for a motivated Master student to join our team! Do you want to optogenetically control metabolic activity to see how metabolism affects patterning and morphogenesis? 💡🧫🧬🔬 Then please apply! #optogenetics #metabolism #devbio #hESCs Please RT. Thank you!🙏

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Theresa Zeisner @theresazeisner.bsky.social · 13/02/2026

Best possible start into the fintastic world of zebrafish! 🐠

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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 03/01/2026

If you want to become an expert in #zebrafish research, apply for the 2026 Zebrafish Development & Genetics course! You will be working in small groups taught by leaders in the field, which can be a transformative experience! Application deadline: March 2 www.mbl.edu/education/ad...

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Theresa Zeisner @theresazeisner.bsky.social · 12/11/2025

🧬 PomBase needs you! 🧬 If you PomBase on a regular basis, now it’s the time to show your support to the team behind this incredibly useful resource (and help them secure funding to keep up the amazing work). Fill out their short user survey, which they will use to support their grant application.

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IMP @impvienna.bsky.social · 10/11/2025

🌍Open call: Junior Group Leader positions! Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery. Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...

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The Francis Crick Institute @crick.ac.uk · 02/10/2025

crick.ac.uk

PhD students

Our PhD programme attracts the brightest scientific minds and is an opportunity for talented people to embark on their career in biomedical research.

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Reposted by Theresa Zeisner

Laura Lorenzo Orts @lorenzoorts.bsky.social · 15/09/2025

I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October. More info: www.imb.de/students-pos...

Reposted by Theresa Zeisner

Adrian Saurin @adesaurin.bsky.social · 01/04/2025

Delighted to share a chemical-genetic system we developed to rapidly inhibit a serine/threonine phosphatase complex (within secs). This will make it much easier to study #phosphatases. The system is also applicable to other “undruggable” enzymes. www.nature.com/articles/s41...

nature.com

A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase reveals a role at metaphase kinetochores - Nature Communications

Phosphatase enzymes are challenging to study due to a lack of specific inhibitors. Here, authors develop a chemical-genetic system to inhibit and characterize a major Ser/Thr phosphatase complex, and ...

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Kristina Stapornwongkul @kstapornwongkul.bsky.social · 20/03/2025

Thrilled to announce that I am looking for a Research Technician/Assistant to join my lab @imbavienna.bsky.social. Please consider applying if you’re enthusiastic about #devbio #stemcells #teamwork and excited to help shaping a new lab! Thankful for any retweet! 🫶 imba.onlyfy.jobs/job/l6u2m980

imba.onlyfy.jobs

Research Technician

IMBA - Institute of Molecular Biotechnology is one of the leading biomedical research institutes in Europe focusing on cutting-edge functional genomics and stem cell technologies. IMBA is located at t...

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Reposted by Theresa Zeisner

Pontus Skoglund @pontus-skoglund.bsky.social · 17/03/2025

We have a 4-year PhD-student opening in our lab, deadline on Wednesday noon. For anyone interested in computational genomics of ancient human, pathogen, or canid genomes. www.crick.ac.uk/careers-stud... If you are curious, send in an application!

crick.ac.uk

Skoglund Lab | Ancient human statistical population genomics

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openRxiv @openrxiv.bsky.social · 11/03/2025

openRxiv has arrived! We’re thrilled to announce the launch of openRxiv as an independent, researcher-led nonprofit to oversee bioRxiv and medRxiv, the world’s leading preprint servers for life and health sciences. openrxiv.org/introducing-... #openRxiv #OpenScience #Preprints #bioRxiv #medRxiv

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Theresa Zeisner @theresazeisner.bsky.social · 07/03/2025

Just under two weeks left to apply for PhD positions at the Crick 🔬🧬 Check out this video featuring @sarahwillich.bsky.social for some application tips youtu.be/XjW4LqwKNFs

youtu.be

Top tips for PhD applicants | The Francis Crick Institute

YouTube video by Francis Crick Institute

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Theresa Zeisner @theresazeisner.bsky.social · 24/02/2025

Big thanks to Tania for her phospho-expertise and the entire Nurse lab (past and present) for their support, comments and discussions! 🌟

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Theresa Zeisner @theresazeisner.bsky.social · 24/02/2025

Without PP2A-B55 or CDC14 cells enter mitosis earlier This advance is independent of CDK activity regulation. This indicates that in the absence of these Ppases, critical CDK substrates can be phosphorylated at lower CDK activity levels (ie earlier), thus advancing mitotic entry.

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Theresa Zeisner @theresazeisner.bsky.social · 24/02/2025

What happens in the absence of the Ppases? Using a fluorescent sensor, we showed that without PP2A-B55, a candidate substrate (Cut3-T19) is phosphorylated earlier and less rapidly.

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Theresa Zeisner @theresazeisner.bsky.social · 24/02/2025

This suggests that the identity of the Ppase that targets a CDK substrate site affects its phosphorylation timing. The exact phosphorylation timing of a given site is determined by a combination of factors.

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Theresa Zeisner @theresazeisner.bsky.social · 24/02/2025

Does the division of labour between the Ppase impact the timing of CDK substrate phosphorylation? Yes! ✅ Phosphoproteomic timecourse showed that CDK substrates targeted by CDC14 and PP2A-B56 are, on average, net phosphorylated first, followed by CDK substrates targeted by PP1 and then PP2A-B55.

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Theresa Zeisner @theresazeisner.bsky.social · 24/02/2025

Identifying some more Ppase substrates… We also identified 3,000+ Ppase substrates phosphorylated by other kinases (not CDK). The identified Ppase motifs were similar to those identified in other eukaryotes, indicating conservation of Ppase substrate specificity.

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Theresa Zeisner @theresazeisner.bsky.social · 24/02/2025

Distinct Ppase targets • PP2A-B55, B56, CDC14 & PP1 targeted specific subgroups of CDK sites • <5% of sites were targeted by multiple Ppases • Ppases had different preferences for amino acids

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Theresa Zeisner @theresazeisner.bsky.social · 24/02/2025

🔎 Identifying Ppase substrates We used phosphoproteomics: inhibiting CDK with & without Ppase and tracking dephosphorylation. We classified a site as a Ppase substrate if it was dephosphorylated substantially slower in the absence of the Ppase.

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Theresa Zeisner @theresazeisner.bsky.social · 24/02/2025

❓Open questions How do CDK-opposing Ppases (PP2A-B55, PP2A-B56, PP1 & CDC14) together influence the phosphorylation timing of CDK substrates? To answer this, we first needed to identify which CDK substrate is targeted by which Ppase.

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Theresa Zeisner @theresazeisner.bsky.social · 24/02/2025

🔄 CDK-opposing Ppases • Important at mitotic exit to dephosphorylate CDK substrates • Ppases are also active during interphase ➡️ could affect phosphorylation timing • But for the majority of CDK substrate sites, it is not known which Ppase targets it

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Theresa Zeisner @theresazeisner.bsky.social · 24/02/2025

⏰ The cell cycle is driven by reversible phosphorylations Hundreds of proteins need to be phosphorylated at the right time by cyclin-dependent kinases (CDKs) to order cell cycle events. These phosphorylations are opposed by phosphatases (Ppases), such as PP2A-B55, PP2A-B56, PP1 & CDC14.

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Theresa Zeisner @theresazeisner.bsky.social · 24/02/2025

🚨New preprint🚨 How do phosphatases affect CDK substrate phosphorylation timing during the cell cycle? We showed that substrates dephosphorylated by different Ppases are net phosphorylated at different times. 📖 Read here: doi.org/10.1101/2025... & follow along for some key insights 🧵

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Theresa Zeisner @theresazeisner.bsky.social · 02/01/2025

🧪 Got a curious 7–11 year-old at home? 🔍 Whether they’re wondering how yeast grows or want to craft some red blood cells, the new Crick Kids website has them covered! 🎉 Discover fun science activities, hands-on experiments, and lots of quizzes 🧬👩‍🔬🔬 👉 Check it out here: kids.crick.ac.uk

kids.crick.ac.uk

Home

We’ve got loads of science experiments, quizzes and crafts for kids and families. Get exploring and see what you discover on Crick Kids.

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Reposted by Theresa Zeisner

The Company of Biologists @biologists.bsky.social · 19/12/2024

🧪The deadline to submit an abstract for oral and poster presentations at our Biologists @ 100 conference has been extended to Friday 17 January 2025. View the abstract topics and submit yours at 100yearsconference.biologists.com/abstracts/ #biologists100

Conference announcement
Join us in Liverpool to celebrate our 100th anniversary

Biologists @ 100

24-27 March 2025, ACC Liverpool, UK
biologists.com/100-years/conference

Register now
Extended abstract deadline:

17 January 2025

#biologists100

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Evangelia Petsalaki @epetsalaki.bsky.social · 21/11/2024

PhosX is out! doi.org/10.1093/bioi... Leveraging the latest kinase specificity maps by the Cantley, Yaffe, and Turk labs and a rank sum statistic we created PhosX so now we can predict activities for nearly all kinases in your phosphodata, including the understudied ones. Check it out!

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