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Theo Mantamadiotis

@theo-braincan-lab.bsky.social
295 followers 266 following 22 posts

Head Brain Cancer Biol Lab | Assoc/Prof@UMelb 🇦🇺 Former Marie-Curie Fellow@UPatras 🇬🇷 DKFZ Connect 🇩🇪 Editorial board: Carcinogenesis (OUP) | Brain | Cancer | Signaling | CREB | Transcription | TME | Spatial Biol shorturl.at/atRwp

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Theo Mantamadiotis @theo-braincan-lab.bsky.social · 15/07/2026
Carcinogenesis invites proposals for special issues that highlight emerging areas of cancer research and integrate discoveries across molecular, cellular, translational, and population sciences. academic.oup.com/carcin/pages...
academic.oup.com
Call for Special Issue Proposals | Carcinogenesis | Oxford Academic
Carcinogenesis: Integrative Cancer Research Carcinogenesis invites proposals for Special Issues that highlight emerging areas of cancer research and integrate
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Theo Mantamadiotis @theo-braincan-lab.bsky.social · 23/02/2026
Our latest research pre-print on BioRxiv: Multi‑omic and spatial analysis reveals tumor‑derived paracrine signals drive suppressive macrophage polarization via activation of the cAMP-CREB axis in glioblastoma www.biorxiv.org/content/10.6...
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Theo Mantamadiotis @theo-braincan-lab.bsky.social · 06/02/2026
Spatial organization of the TME explored using #spatialbiology. Neoplastic cell signaling and TME complexity are not only dependent on cell intrinsic genetics, but also dependent on cell density & stromal interaction. #cellsignaling #microenvironment #brain #GBM
multiplex IHC using cell signaling, cell proliferation and cell type biomarkers in human GBM tissue (top left); tumorspheres (bottom left) & mouse brain tumor tissue (right)
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Reposted by Theo Mantamadiotis
Carcinogenesis_Oxford Uni Press Journal @carcin-oxfunipress.bsky.social · 11/11/2025
ONLINE NOW: Special Issue on Radiation, Humanity, and Hope: 80 Years of Cancer Research Post-Hiroshima and Nagasaki academic.oup.com/carcin/issue...
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Carcinogenesis_Oxford Uni Press Journal @carcin-oxfunipress.bsky.social · 11/11/2025
Eighty years of cancer research after the atomic bombings of Hiroshima and Nagasaki doi.org/10.1093/carc...
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Carcinogenesis_Oxford Uni Press Journal @carcin-oxfunipress.bsky.social · 08/09/2025
Nobel laureate, molecular biologist & cancer researcher, David Baltimore, died at he age of 87. shorturl.at/2t7Ya In 1975, he shared the Nobel Prize in Physiology or Medicine for discovering reverse transcriptase, challenging the view that genetic information was only transferred from DNA to RNA
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Carcinogenesis_Oxford Uni Press Journal @carcin-oxfunipress.bsky.social · 12/08/2025
Radiation, Humanity, and Hope: 80 Years of Cancer Research Post-Hiroshima & Nagasaki In September, Carcinogenesis will publish a special issue to commemorate the 80th anniversary of the atomic bombings in Japan, & our understanding of radiation & its impact on human health academic.oup.com/carcin
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Theo Mantamadiotis @theo-braincan-lab.bsky.social · 04/08/2025
Delighted to present our research at the #Spatial Imaging Workshop, hosted by Biological Optical Microscopy Platform (BOMP) @ The University of Melbourne & supported by Leica Microsystems & Light Microscopy Australia. The multiplex IHC image shows cell signaling activity using phospho-Abs in #GBM
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Theo Mantamadiotis @theo-braincan-lab.bsky.social · 06/06/2025
The Who's Who of spatial biology in Australia & SE Asia at the WEHI Spatial Technology Symposium in Melbourne. A fabulous lineup of speakers & platform leaders highlighting the fast moving research & tech in #spatial #biology
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Theo Mantamadiotis @theo-braincan-lab.bsky.social · 05/03/2025
I’m delighted to join the Cure Brain Cancer Foundation Scientific Advisory Committee & look forward to working with the CBCF, consumer advocates & researchers, to advance our understanding of the mechanisms underpinning brain cancer, to ultimately help patients and their families.
The two newest members of the Cure Brain Cancer Foundation, Scientific Advisory Committee
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Theo Mantamadiotis @theo-braincan-lab.bsky.social · 26/02/2025
Multiomics Blueprint of Extreme Human Lifespan: “The picture…emerges…that extremely advanced age & poor health are not intrinsically linked & that both processes can be distinguished & dissected at the molecular level” Santos-Pujol et al., doi.org/10.1101/2025...
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The Platten Lab @platten-lab.bsky.social · 11/02/2025
🚀 New publication! We developed a PTPRZ1-specific TCR-T cell therapy for glioblastoma. 🔬 Key findings: ✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient ✅ Kills glioblastoma cells with no off-target effects ✅ Eliminates tumors in murine brain models 🔗 www.nature.com/articles/s41...
nature.com
Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen - Nature Communications
Vaccination in glioblastomas does lead to the emergence of tumour-antigen-specific T cells but T cell dysfunction, poor tumour infiltration and persistence hinder efficient tumour killing. Here author...
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Theo Mantamadiotis @theo-braincan-lab.bsky.social · 04/02/2025
The University of Melbourne, Brownless Biomedical Library this morning & as it was: For me, it was the place to leaf through the latest hardcopy journal issues on the display stands, or search the journal archives for that elusive article required for my thesis
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Theo Mantamadiotis @theo-braincan-lab.bsky.social · 01/02/2025
#GBM #TME #spatial analysis: incredible #cellsignaling heterogeneity at single cell resolution, predicts cell function. Differential PI3K-MAPK-CREB pathway activation/co-activation correlates with proliferation, cell density, angiogenesis & proximity to ECM-rich stroma: see go.unimelb.edu.au/52z8
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Theo Mantamadiotis @theo-braincan-lab.bsky.social · 01/02/2025
While updating my CV for another grant application, I am yet again amused by the title of our review article (PDF version), from 2011 (the title is correct on PubMed & the journal web site). I never followed up to fix this because it's great as it i; at the cutting edge of science & mythology:
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 31/01/2025
bit.ly
Microenvironmental determinants of endothelial cell heterogeneity
Nature Reviews Molecular Cell Biology, Published online: 28 January 2025; doi:10.1038/s41580-024-00825-wEndothelial cells (ECs) undergo organ-specific specialization, driven by microenvironmental cues, to form patterned vascular networks. This article…
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Nicholas A. Christakis @nachristakis.bsky.social · 24/01/2025
Bilingualism is associated with a bigger brain. Similar to other cognitively demanding skills, it leads to dynamic subcortical structural adaptations which can be nonlinear, in line with expansion-renormalisation models of experience-dependent neuroplasticity. www.nature.com/articles/s41...
nature.com
Dynamic effects of bilingualism on brain structure map onto general principles of experience-based neuroplasticity - Scientific Reports
Scientific Reports - Dynamic effects of bilingualism on brain structure map onto general principles of experience-based neuroplasticity
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Reposted by Theo Mantamadiotis
Roel Verhaak @roelverhaak.bsky.social · 03/01/2025
Great story; Gliomagenesis mimics an injury response orchestrated by neural crest-like cells www.nature.com/articles/s41...
nature.com
Gliomagenesis mimics an injury response orchestrated by neural crest-like cells - Nature
A study using glioblastoma mouse models, serial magnetic resonance imaging and single-cell profiling details changes in the identity and balance of cellular states from initiation of tumorigenesis to ...
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Theo Mantamadiotis @theo-braincan-lab.bsky.social · 03/01/2025
Fascinating study!
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Theo Mantamadiotis @theo-braincan-lab.bsky.social · 24/12/2024
Merry Christmas! Καλά Χριστούγεννα! Frohe Weihnachten!
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Theo Mantamadiotis @theo-braincan-lab.bsky.social · 18/12/2024
Unraveling the functional complexity of the tumor microenvironment via #spatialbiology. The 2 images show rGBM tissue with cell signaling cell plot (left) & cell-type mIHC (right). Neoplastic, vascular & immune cells show distinct signals which correlate with cell clustering & proximity to ECM
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Theo Mantamadiotis @theo-braincan-lab.bsky.social · 16/12/2024
In Carcinogenesis: shorturl.at/6pvy6 Male mice with nestin-targeted PI3K & PTEN mutations develop tumors which resemble an aggressive form of sex cord stromal tumors. We describe the cell-of-origin, the complex histopathology & using #spatialbiology, the immune cell infiltration of this rare cancer
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Theo Mantamadiotis @theo-braincan-lab.bsky.social · 01/12/2024
Well done Samuel! Last week, Samuel Widodo submitted his PhD thesis: "Signalling and Transcriptional Regulation of Tumour Associated Macrophage Polarisation in Brain Cancer" @UniMelb & has published 12 papers, so far, with some shown here. #glioblastoma #GBM #spatialbiology #OMICS #macrophages
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Irene Miguel-Aliaga @irenemiguel-aliaga.bsky.social · 23/11/2024
Amazing: 3D organ-wide spatial analysis. (Almost) all of it: real-time methods for 4D analysis next? www.science.org/doi/10.1126/...
science.org
Whole-brain spatial transcriptional analysis at cellular resolution
Recent advances in RNA analysis have deepened our understanding of cellular states in biological tissues. However, a substantial gap remains in integrating RNA expression data with spatial context acr...
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Theo Mantamadiotis @theo-braincan-lab.bsky.social · 24/11/2024
Mice with an inducible nestin-CreER transgene targeting PI3K & PTEN develop aggressive brain tumors doi.org/10.1093/neuo... ~20% of the mice also show tumours affecting the reproductive organs. Using #spatialbiology we describe the testis tumors, in the bioRxiv pre-print: doi.org/10.1101/2024...
HE stained testis exhibiting a sex cord stromal-like tumor on the left & in the right, a spatial map showing tumor & immune cells (see color key)
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Theo Mantamadiotis @theo-braincan-lab.bsky.social · 24/11/2024
To learn about #braincancer & the innovative use of mIHC #spatialbiology tech to understand key molecular & cellular mechanisms regulating the #tumormicroenvironment, go to: shorturl.at/Nafcw #GBM #brain #cancer
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Theo Mantamadiotis @theo-braincan-lab.bsky.social · 23/11/2024
1st Bsky post pushed from you know where - Following several presentations on how we use #spatialbiology to investigate the #immunology of #braincancer - also see our recent review on this topic shorturl.at/7pwV1
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