A new review article discusses the ATP-gated P2X7 receptor; an example where protein structure-function alteration in cancer cells favors cell survival, by conversion of the cytolytic macropore functional form to a macropore-deficient P2X7 form.
doi.org/10.1093/carc...
doi.org
The P2X7 Receptor in Cancer: From Functional Receptor to Non-Functional P2X7
Abstract. The ATP-gated P2X7 receptors are abundantly expressed in immune cells, neurons, glial cells, and cancer cells. The P2X7 receptor performs distinc