iiinova — where your digital self keeps evolving

Terkild Brink Buus @terkild.bsky.social · 17/04/2026

New from our group: in CTCL, S. aureus is not just a bystander. Staphylococcal enterotoxins activate malignant + non-malignant T cells, amplifying cytokines that damage the epidermal barrier. This links colonization directly to pathology. doi.org/10.1111/all.70292 @allergy-eaaci.bsky.social 1/8

doi.org

Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma

Staphylococcus aureus, commonly colonising CTCL patients, augments skin barrier dysfunction. Staphylococcal enterotoxins induce T-cell release of barrier-repressing cytokines (IL-4, IL-13, IL-22, OSM...

220

Terkild Brink Buus @terkild.bsky.social · 17/04/2026

Happy to share that I’ve been promoted to Associate Professor @sic-ucph.bsky.social @ucph.bsky.social . Very grateful to the mentors, group members, colleagues, students, collaborators, and family who have supported me along the way. Thank you. Looking forward to the next chapter!

050

Reposted by Terkild Brink Buus

LEO Foundation Skin Immunology Research Center (SIC) @sic-ucph.bsky.social · 09/12/2025

📣 SIC Summer School 2026 — applications open! 📍Hornbæk, DK | 18–20 May 2026 🎯Theme: Skin Immunity & Homeostasis 💵Free (stay + meals). For PhD students & postdocs. ✍️Deadline: 15 Jan 2026 (23:59 CET). 🔗Full details: sic.ku.dk/summerschool/ 🔗Register here: eventsignup.ku.dk/sicss2026

1113

Terkild Brink Buus @terkild.bsky.social · 06/11/2025

Glad to see our article on how cancer drugs and bacterial (S. aureus) infections can affect co-existing malignant subclones very differently in cutaneous T-cell lymphoma. Thank you Cancer Discovery (@aacrjournals.bsky.social) for the beautiful title-page graphics!

Front page of article Buus et al. 2025 Cancer Discovery, including graphics showing red and orange malignant T cell subclones in a blue skin environment.

082

Reposted by Terkild Brink Buus

niels-odum.bsky.social @niels-odum.bsky.social · 30/06/2025

Congratulations Terkild and the team👏💪😊 very important new knowledge on the intricacies of this horrible cancer - this new understanding of coexisting yet specialized cancer subclones is a key discovery for a truly targeted treatment in the future !!!! Bravo 👏👏👏

061

Reposted by Terkild Brink Buus

Terkild Brink Buus @terkild.bsky.social · 19/06/2025

❗How can a cancer exploit its environment and still resist treatment? ✅The answer: co-existing malignant subclones. Let me walk you through our latest study investigating how divergent evolution drives adaptability, aggressiveness, and drug resistance of T cell cancer. 1/🧵 doi.org/10.1158/2159...

Schematic figure showing divergent evolution of malignant subclones and how they migrate to different tissue compartments (blood vs skin), respond differently to extrinsic stimuli such as Staphylococcus aureus enterotoxins, and how subclones differ in their intrinsic resistance to anti-cancer drugs.

2249

Terkild Brink Buus @terkild.bsky.social · 19/06/2025

2249

Reposted by Terkild Brink Buus

Elizabeth McKenna @elizsmckenna.bsky.social · 17/06/2025

Now online in Cancer Discovery: Divergent Evolution of Malignant Subclones Maintains a Balance Between Induced Aggressiveness and Intrinsic Drug Resistance in T Cell Cancer - by @terkild.bsky.social,‬ @niels-odum.bsky.social, and colleagues doi.org/10.1158/2159... @ucph.bsky.social

062

Terkild Brink Buus @terkild.bsky.social · 18/11/2024

Can bacterial infections make cancer cells resistant to treatment? In Sézary Syndrome (SS), it turns out they can! Want to know more? I will summarize some highlights from our study below. doi.org/10.1182/bloo...

doi.org

Staphylococcus aureus induces drug resistance in cancer T cells in Sézary syndrome

Enterotoxins from S aureus bacteria induce drug resistance in primary malignant T cells in SS.Targeting bacteria, their toxins, and downstream signaling pa

190

Reposted by Terkild Brink Buus

Santiago Carmona 🧬 🖥️ 🧑🏾‍🔬 @carmonation.bsky.social · 15/11/2024

in case this is useful to someone in this massive platform migration: a starting pack for single-cell omics computational methods go.bsky.app/GmS1cH

go.bsky.app

single-cell computational methods

Join the conversation

159847

Terkild Brink Buus @terkild.bsky.social · 16/11/2024

Any starter packs around for researchers in single-cell method development (not computational), dermatology, inflammatory skin disease, atopic dermatitis or cutaneous T cell lymphoma?

040