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Teresa Spanò

@teresaspano.bsky.social
133 followers 281 following 9 posts

postdoc @ MPI for Brain Research. 🧠🔬 before: University of Edinburgh & NCBS. she/her. 🇮🇹🏴󠁧󠁢󠁳󠁣󠁴󠁿🇮🇳🇩🇪

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Reposted by Teresa Spanò
Max Planck Institute for Brain Research @mpibrain.bsky.social · 01/10/2026
Scientists at the Schuman Lab @mpibrain.bsky.social reveal extensive mRNA localization and local protein synthesis in cortical layer 1 , shedding light on how distant synapses may maintain and modify themselves 🧠. @teresaspano.bsky.social Full story: 🔗 bit.ly/4rJJWnJ #BrainResearch #Cortex
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Reposted by Teresa Spanò
Philipp Brand @pbrand.bsky.social · 01/09/2026
We are looking for a research assistant to join our team. brain.mpg.de/brand Apply using the link below if you are interested in doing research on the neural and genetic underpinnings of behavioral evolution. jobs.brain.mpg.de/jobposting/6...
Description of job ad for Research Assistant in the lab of Evolutionary Neuroscience and Behavior Lab at the Max Planck Institute for Brain Research.Description of job ad for Research Assistant in the lab of Evolutionary Neuroscience and Behavior Lab at the Max Planck Institute for Brain Research.
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Teresa Spanò @teresaspano.bsky.social · 03/08/2026
Happy that our research on mRNA localization, synaptic diversity and local protein synthesis in layer 1 is now out in Cell Reports! 🧬🧠 Read it in full here 👉 doi.org/10.1016/j.ce... and browse the data here 👉 syndive.org @cp-cellreports.bsky.social @mpibrain.bsky.social
doi.org
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Teresa Spanò @teresaspano.bsky.social · 25/11/2025
Thanks to @erin-schuman.bsky.social , @evakaulich.bsky.social and other co-authors, and @mpibrain.bsky.social for all the support 🙂🧠 looking forward to your feedback!
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Teresa Spanò @teresaspano.bsky.social · 25/11/2025
Finally, we discovered that the transcriptome of layer 1 resembles that of stratum lacunosum moleculare in the hippocampus – indicating that the molecular environment of these distal layers might have been conserved.
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Teresa Spanò @teresaspano.bsky.social · 25/11/2025
By comparing layer 1 synapses to synapses from deeper layers, we found significant transcriptomic differences. This shows that the sets of mRNAs localized to synapses change depending on cortical layer, potentially conferring specialized function.
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Teresa Spanò @teresaspano.bsky.social · 25/11/2025
We used metabolic labelling and FISH to discover that local protein synthesis is indeed a feature of layer 1. We characterized the transcriptome of layer 1 and its synapses, discovering >1000 transcripts localized at excitatory synapses, and a distinct set of mRNAs localized at inhibitory synapses.
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Teresa Spanò @teresaspano.bsky.social · 25/11/2025
Decades of work, on the other hand, have shown that local protein synthesis is an important mechanism for neuronal function and plasticity – yet it is unknown how this process is regulated in the cortex, and whether it is used to achieve layer-specific function.
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Teresa Spanò @teresaspano.bsky.social · 25/11/2025
Cortical layer 1 integrates top-down inputs with bottom-up information and undergoes plasticity during learning, but we don’t know much about the underlying molecular mechanisms.
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Teresa Spanò @teresaspano.bsky.social · 25/11/2025
I’m excited to share my PhD work on localized mRNAs and protein synthesis in cortical layer 1 on bioRxiv! www.biorxiv.org/content/10.1...
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Reposted by Teresa Spanò
Felix Baier @felixbaier.bsky.social · 23/07/2025
🚨Very happy that my PhD work is now out in @nature.com! We discovered that evolution, by acting in the midbrain, shifted the threshold to escape in Peromyscus mice, to fine-tune defensive strategies in different environments www.nature.com/articles/s41... This was a truly collaborative effort! 🧵⬇️
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Reposted by Teresa Spanò
Mara Mueller @muellermara.bsky.social · 28/04/2025
New Preprint out ! The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator www.biorxiv.org/content/10.1... Lead by: @sgiando.bsky.social with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more Short thread below 🧵1/4
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Reposted by Teresa Spanò
Carl T. Bergstrom @carlbergstrom.com · 29/04/2025
Remember when in March of 2020 Trump said he didn't want to test people for COVID because he liked the numbers the way they were? That, but for climate.
nytimes.com
National Climate Assessment Authors Are Dismissed by Trump Administration (Gift Article)
The Trump administration told researchers it was “releasing” them from their roles. It puts the future of the assessment, which is required by Congress, in doubt.
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Reposted by Teresa Spanò
bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 21/02/2025
Connectomic analysis of astrocyte-synapse interactions in the cerebral cortex www.biorxiv.org/content/10.1101/202…
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Reposted by Teresa Spanò
Felix Baier @felixbaier.bsky.social · 12/02/2025
This is a few weeks old, but LIZARDS NEVER GET OLD 🦎😇 Find out what makes them so interesting in our Creature Column @naturemethods.bsky.social
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Reposted by Teresa Spanò
Tamas Dalmay @tdalmay.bsky.social · 12/02/2025
How do different sensory signals combine in the computation of cognitive maps? I’m thrilled to share our new preprint, in which we investigate this question in the context of the head-direction system: www.biorxiv.org/content/10.1...
biorxiv.org
Joint visual-vestibular computation of head direction and reflexive eye movement
Several cognitive maps have been identified, but what sensory signals drive them and how these are combined are not well understood. One such map, the head-direction representation, is believed to be ...
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Teresa Spanò @teresaspano.bsky.social · 12/02/2025
Good luck! 😊💪
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Reposted by Teresa Spanò
Jonathan A. Michaels @jonathanamichaels.bsky.social · 20/01/2025
Reflective piece by Eve Marder – "What happened to the pursuit of truth" rupress.org/jgp/article/...
rupress.org
What happened to the pursuit of truth? | Journal of General Physiology | Rockefeller University Press
The knowledge in our brains, not in our phones, is necessary for creative thinking and the pursuit of truth.
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