iiinova — where your digital self keeps evolving

Tal Sharf @talsharf.bsky.social · 05/05/2026

New work from the lab is up on bioRxiv, where we introduce “SpikeLab: Agentic tools for spike data analysis” was led by postdoc Tjitse van der Molen and supported the crew at @ucscgenomics.bsky.social and @baskinengineering.bsky.social www.biorxiv.org/content/10.6...

111

Reposted by Tal Sharf

Matteo Carandini @carandinilab.net · 22/12/2025

Sequences are everywhere! In every brain region. And are written in stone. Invariant Activity Sequences Across the Mouse Brain. Out today, by Célian Bimbard, with @kenneth-harris.bsky.social. Based on data by Célian and by @intlbrainlab.bsky.social. www.biorxiv.org/content/10.6...

Examples of sequences of activity seen in multiple regions of the brain

48324

Reposted by Tal Sharf

Kevin Mitchell @wiringthebrain.bsky.social · 25/11/2025

Slate status: not blank

2324

Tal Sharf @talsharf.bsky.social · 25/11/2025

I was told it would take about three years to get a new lab up and running. Nearly three years later, our work on preconfigured neuronal firing sequences in human brain organoids is finally out in Nature Neuroscience: www.nature.com/articles/s41...

nature.com

Preconfigured neuronal firing sequences in human brain organoids - Nature Neuroscience

Examining human brain organoids and ex vivo neonatal murine cortical slices demonstrates that structured neuronal sequences emerge independently of sensory input, highlighting the potential of brain o...

160

Tal Sharf @talsharf.bsky.social · 31/10/2025

"We can, should, and will use cerebral organoids to discover new medical treatments, study brain development, reduce the demand for animal testing, and even power computers and more energy-efficient AI." www.vox.com/future-perfe...

vox.com

The challenge of creating brains in a lab

Lab-grown brains don’t have to inspire horror.

010

Reposted by Tal Sharf

Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 28/10/2025

In an NSF-supported study, @talsharf.bsky.social and collaborators will investigate the capacity of human brain organoids to learn and adapt, with implications for #organoid research, #bioethics, and science education. news.ucsc.edu/2025/10/lear...

news.ucsc.edu

Effort aims to uncover the learning and reasoning potential of brain organoids

The Braingeneers team will to test the ability of brain organoids to solve tasks in real time

041

Reposted by Tal Sharf

Carsen Stringer @computingnature.bsky.social · 12/01/2025

What if… spontaneous neural activity 🧠 reflects the baseline rumblings of a brainwide dynamical system initialized for learning? We find that the rumblings have macroscopic properties like those emerging from linear symmetric, critical systems 🧵 #neuroscience #neuroAI www.biorxiv.org/content/10.1...

schematic of neural recordings from mouse V1, whole-brain, and hippocampus; neural activity traces from the population, showing more correlated activity in V1 and whole-brain recordings versus more decorrelated activity in hippocampus

931083

Reposted by Tal Sharf

Yoshiho Ikeuchi @yoshihoikeuchi.bsky.social · 17/01/2025

Our manuscript preprint is out!

012

Tal Sharf @talsharf.bsky.social · 09/01/2025

I’m thrilled to share our revised work on neuronal sequences in brain #organoids. It has been an absolute joy to collaborate with an incredible team of talented experimental and computational neuroscientists brought together by this project. www.biorxiv.org/content/10.1...

biorxiv.org

Protosequences in brain organoids model intrinsic brain states

Neuronal firing sequences are thought to be the basic building blocks of neural coding and information broadcasting within the brain. However, when sequences emerge during neurodevelopment remains unk...

131