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Synthesis Workshop @synthesisworkshop.bsky.social · 7h

This week, Violet YJ Chen presents a new ChemDev poster on an improved manufacturing route to ceralasertib (an orally bioavailable inhibitor of ATR kinase), by Mark Graham and colleagues at AstraZeneca! doi.org/10.1021/acs.... doi.org/10.1021/acs....

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Synthesis Workshop @synthesisworkshop.bsky.social · 08/10/2026

We are currently in the process of expanding our Editorial Board at Synthesis Workshop! If you are interested in supporting our not-for-profit initiative aimed at bringing visibility to the latest advances in organic synthesis on a volunteer basis, feel free to reach out!

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Synthesis Workshop @synthesisworkshop.bsky.social · 11/09/2026

Tune in this week as Mauro Mato shares his work on a photoredox strategy for unmasking C-H bonds! Link: youtu.be/VW2X6KeLiFY Key paper: @jacs.acspublications.org 2026, 148, 5946–5952 doi.org/10.1021/jacs... Thanks to Kathleen for editing and hosting!

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Synthesis Workshop @synthesisworkshop.bsky.social · 29/08/2026

Today we are joined by Dr. Alexander Düfert, who discusses with us his new book, Methods of Organic Synthesis in a talk followed by a Q&A session with our editorial board! Link: youtu.be/ctVRA18Wwcc @springernature.com: link.springer.com/book/10.1007... Thanks to Alicia for hosting!

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Synthesis Workshop @synthesisworkshop.bsky.social · 01/08/2026

This week we are excited to present our August ChemDev poster, focusing on the development of a manufacturing process for the COVID-19 antiviral ensitrelvir! This poster is brought to you by our Associate Editor of ChemDev Posters, Violet YJ Chen! Key reference: doi.org/10.1021/acsc...

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Synthesis Workshop @synthesisworkshop.bsky.social · 05/07/2026

This week Violet YJ Chen highlights the development of a manufacturing process for a key intermediate of orforglipron (a non-peptide GLP-1 receptor agonist) by the team at Lilly! Key papers: doi.org/10.1021/acs.... doi.org/10.1021/acs.... doi.org/10.1021/acs....

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Synthesis Workshop @synthesisworkshop.bsky.social · 06/06/2026

In this month's ChemDev poster by Augustin "Gus" Péneau, we explore the process development behind a campaign to establish a manufacturing route for a topical pan-Trk inhibitor by Neil Stevenson with the BenevolentAI team! Key paper: doi.org/10.1021/acs....

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Synthesis Workshop @synthesisworkshop.bsky.social · 09/05/2026

Today Augustin "Gus" Péneau presents our ChemDev poster for May, featuring a convergent synthesis of GNE-6893 by the small molecule process team at Genentech! For more details check out the papers here: doi.org/10.1021/acs.... doi.org/10.1021/acsm... @acs.org

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Synthesis Workshop @synthesisworkshop.bsky.social · 11/04/2026

Tune in this week as Xieyang Zhang shares his work on catalytic stereospecific construction of aminocyclopropanes from the Morken group at Boston College! Link: youtu.be/UE-S8R3zd60 Key paper: @jacs.acspublications.org 2026, 148, 3944-3948. doi.org/10.1021/jacs...

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Synthesis Workshop @synthesisworkshop.bsky.social · 04/04/2026

This month's ChemDev poster by Augustin "Gus" Péneau is out now!! Check out how chemists from AbbVie scaled the synthesis of ABBV-105, a Bruton’s tyrosine kinase (BTK)-inhibitor! Key paper: Org. Process Res. Dev. 2024, 28, 8, 3229–3247 doi.org/10.1021/acs....

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Synthesis Workshop @synthesisworkshop.bsky.social · 07/03/2026

Check out the first poster by Augustin "Gus" Péneau in our new monthly ChemDev virtual poster series, showing how syntheses evolve from Med Chem to Process Development. This poster highlights developments in the synthesis of the oral ERα degrader camizestrant!

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Synthesis Workshop @synthesisworkshop.bsky.social · 14/02/2026

Tune in this week on Synthesis Workshop as Bryan Parnitzke shares his work on Z-selective semihydrogenation reactions proceeding via multisite proton-coupled electron transfer!! Link: youtu.be/S2NS3sL6_g0 Key paper: ACS Catal. 2026, 16, 1, 203–210. doi.org/10.1021/acsc...

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Synthesis Workshop @synthesisworkshop.bsky.social · 24/01/2026

Tune in this week as Dr. Terrence-Thang Nguyen shares his work on asymmetric C-H functionalization and the synthesis of (-)-dragocin D!! Link: youtu.be/Gh1qxy7Z7K0 @jacs.acspublications.org 2025, 147, 31, 28098–28106. doi.org/10.1021/jacs... Thanks to Kathleen for hosting!

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Synthesis Workshop @synthesisworkshop.bsky.social · 17/01/2026

Once you've seen the episode, head over to synthesis-workshop.com/problem-sets to check out the accompanying problem and solution set!!

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Synthesis Workshop @synthesisworkshop.bsky.social · 03/01/2026

Tune in for our first Research Spotlight of 2026, where Dr. Ruocheng Sang shares his work on a radical approach to the boron-to-copper transmetalation problem!! Link: youtu.be/EVtEZwUSrbU @jacs.acspublications.org doi.org/10.1021/jacs...

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Synthesis Workshop @synthesisworkshop.bsky.social · 29/11/2025

Join us today as Dr. Mikus Purins shares his work recently published in @science.org on bridging the pyridine-pyridazine synthesis gap using skeletal editing! Link: youtu.be/k2nOfYnNk6U Key paper: Science 2025, 389(6757), 295-298. www.science.org/doi/10.1126/... Thanks to Karim for hosting!!

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Synthesis Workshop @synthesisworkshop.bsky.social · 08/11/2025

Is it possible to form a stereogenic carbon with four heteroatom substituents? Would it be configurationally stable? Tune in today to find out in a brand new episode with Olivier Viudes, hosted by Alicia Wagner! Link: youtu.be/-pyvGu56Suo @jacs.acspublications.org 2025, 147, 21121.

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Synthesis Workshop @synthesisworkshop.bsky.social · 01/11/2025

We have a brand new Research Spotlight episode, as well as a Problem Set and Solution set dropping today!! Tune in to learn about diastereoselective umpolung cyclization reactions with Dr. Giulia Iannelli! Link: youtu.be/uyKZgUbB5Fk Link to our problem sets: synthesis-workshop.com/problem-sets.

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Synthesis Workshop @synthesisworkshop.bsky.social · 18/10/2025

Tune in today for a brand new Research Spotlight episode with Charlotte O’Donnell, focusing on her recent total synthesis of aspidospermidine! Link: youtu.be/lzDv8cJRTyQ

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Synthesis Workshop @synthesisworkshop.bsky.social · 11/10/2025

Tune in today to hear Dr. Fabian Kallmeier explain how to enhance the nucleophilicity of aluminum anions, which he recently published in @chemicalscience.rsc.org, in a brand new Research Spotlight episode! Link: youtu.be/6XBF6Iqi3vE Key paper: doi.org/10.1039/D5SC...

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Synthesis Workshop @synthesisworkshop.bsky.social · 06/09/2025

Join us today to learn about controlled anionic polymerizations with Paige Jacky, focusing on her recently published work in Nature Chemistry!! Link: youtu.be/6XD7dBUByyQ Nat Chem. 2025, 17, 1076-1082. doi.org/10.1038/s415...

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Synthesis Workshop @synthesisworkshop.bsky.social · 23/08/2025

This talk also comes with a great hands on tutorial activity designed by the speaker - check it out at synthesis-workshop.com/courses!

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Synthesis Workshop @synthesisworkshop.bsky.social · 09/08/2025

Join us today to hear from Ann-Sophie Paschke and Stefanie Schiele from the @morandilab.bsky.social about their work on C-to-N atom swapping reactions!! Thanks to Karim for hosting and editing! Link: youtu.be/D513hX1gOTg @chemicalscience.rsc.org doi.org/10.1039/D5SC...

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Synthesis Workshop @synthesisworkshop.bsky.social · 18/07/2025

Very excited to announce that our recent review has been featured on the cover of Synthesis!! If you haven't had a chance to check it out yet, here is a link to the review: doi.org/10.1055/a-26...

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Synthesis Workshop @synthesisworkshop.bsky.social · 12/07/2025

Join us this week as Jonathan Gruhin @alexanian-lab.bsky.social shares his work on the homologation of carboxylic acids! Thanks to Alicia Wagner for hosting and editing!! Link: youtu.be/hbrrRyy0zfU Key paper: J. Am. Chem. Soc. 2024, 146, 48, 32919–32924 doi.org/10.1021/jacs...

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Synthesis Workshop @synthesisworkshop.bsky.social · 04/06/2025

Today Ömer Taşpınar joins us to share his work from the Clayden group on asymmetric intramolecular arylation reactions in a virtual research poster!! Check out the full paper, published under a month ago in Angewandte Chemie here: doi.org/10.1002/anie...

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Synthesis Workshop @synthesisworkshop.bsky.social · 26/04/2025

This is just one example of the problems you'll find in our latest problem set on covalent and noncovalent organocatalysis!! Check out the full set at synthesis-workshop.com in the Problem Sets or Courses section (see the Asymmetric Organocatalysis course).

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Synthesis Workshop @synthesisworkshop.bsky.social · 28/03/2025

Join us this week as Rahul Giri shares his work on dual-functional group transfer reagents for the dihalogenation of hydrocarbons!! Thanks to Andy for hosting! Link: youtu.be/eL7dFssUHcA

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Synthesis Workshop @synthesisworkshop.bsky.social · 08/03/2025

Join us today as Nicolò Tampellini shares his recently published work on asymmetric cyclization reactions!! Link: youtu.be/9e4Hxt5FjH4 J. Am. Chem. Soc. 2025, 147, 4624-4630. doi.org/10.1021/jacs...

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Synthesis Workshop @synthesisworkshop.bsky.social · 05/03/2025

Also check out our new problem and solution set on synthetic electrochemistry, created by Dr. Peter Bellotti! Available for download for free on our project homepage in the Courses or Problem Set section (www.synthesis-workshop.com)!

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Synthesis Workshop @synthesisworkshop.bsky.social · 05/03/2025

Tune in for an ⚡⚡⚡ELECTRIFYING⚡⚡⚡ talk! Today we release our introductory mini-course on synthetic electrochemistry, led by Dr. Max Palkowitz and hosted by Alicia Wagner!! Link: youtu.be/pBW4xHF2bBw

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Synthesis Workshop @synthesisworkshop.bsky.social · 14/02/2025

Join us this week to hear from Enric Adillon about his work on a carborane-derived proton-coupled electron-transfer reagent!! Thanks to Matteo Balletti for hosting! Link: youtu.be/PDAUl-I8e3g Key reference: J. Am. Chem. Soc. 2024, 146, 30204-30211. doi.org/10.1021/jacs...

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Synthesis Workshop @synthesisworkshop.bsky.social · 08/02/2025

Did you like our Advanced Organic Chemistry course Good news! You can now download all the PDFs on our project homepage: synthesis-workshop.com#downloads Haven't seen the course yet? Check it out! www.youtube.com/playlist?lis...

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Synthesis Workshop @synthesisworkshop.bsky.social · 07/02/2025

A sneak peak of the incredible finale of this talk!

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Synthesis Workshop @synthesisworkshop.bsky.social · 07/02/2025

Tune in to see an incredible recent total synthesis, explained by Hiroshige Ogawa!! Thanks to Kathleen for hosting! Link: youtu.be/qVz9znlbeFg @angewandtechemie.bsky.social Int. Ed. 2024, e202414295. doi.org/10.1002/anie...

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Synthesis Workshop @synthesisworkshop.bsky.social · 26/01/2025

Check out our latest Research Spotlight with Liam Franov on electroinduced alkene-aldehyde couplings! Link: youtu.be/_gDvUnRoWag Key paper: J. Am. Chem. Soc. 2024, 146, 29450-29461. doi.org/10.1021/jacs...

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