iiinova — where your digital self keeps evolving

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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 26/08/2026

Foldseek-Interface enables fast search/clustering of the protein interface universe! We clustered 3.1M PDB dimers into 77,167 groups and found new interfaces keep appearing even as fold discovery plateaus. 🧵 📄 www.biorxiv.org/content/10.6... 🔎 search.foldseek.com/interface 🌐 interface.foldseek.com

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Reposted by Sunny (SunJae) Lee

Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 19/06/2026

ICML is happening in Seoul this year, and I’ve been getting several messages about lab visits. Who else will be in town and would like to meet? @milot.bsky.social lab and mine are planning a dinner on July 7th, after the reception. Let me know if you’re interested!

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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 06/06/2026

Folddisco is now published @natbiotech.nature.com. It’s a fast motif search for similar 3D DISCOntinuous residues like catalytic sites or zinc fingers across the entire protein universe. 📄 www.nature.com/articles/s41... 💾 folddisco.foldseek.com 🌐 search.foldseek.com/folddisco

nature.com

Structural motif search across the protein universe with Folddisco - Nature Biotechnology

Folddisco enables protein structural motif search in million scale databases.

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Jaebeom Kim @jbeom.bsky.social · 09/04/2026

Metabuli & Metabuli App v1.2 improve novel species classification with higher precision and recall. New light mode is 1.8× faster and requires 50% less storage while keeping precision. New RefSeq, GTDB, HRGM, and HROM databases added. 💾 github.com/steineggerla... 📄 doi.org/10.64898/2026.03.13.711249

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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 22/10/2025

End-to-end protein design in the browser through evedesign. Generate and interactively explore designs in 2D/3D and export them as codon-optimized DNA. The underlying open source framework (released soon) is build to easily add new methods, more on that soon. 🌐 evedesign.bio

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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 16/10/2025

Our Metabuli taxonomic classifier is now available as an app compatible with Windows, Linux, and macOS. It features an interactive visualization developed by @sunjaelee.bsky.social, along with improvements to Metabuli by @jbeom.bsky.social. 📄 academic.oup.com/bioinformati...

academic.oup.com

Easy and interactive taxonomic profiling with Metabuli App

AbstractSummary. Accurate metagenomic taxonomic profiling is critical for understanding microbial communities. However, computational analysis often requir

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Jaebeom Kim @jbeom.bsky.social · 16/10/2025

Easy and interactive taxonomic profiling with Metabuli App. It integrates database curation, read QC, taxonomic profiling, and visualization right on your desktop. No command line, server, or internet required. Now published in Bioinformatics! 🧵1/5 doi.org/10.1093/bioi... github.com/steineggerla...

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Stephen Turner @stephenturner.us · 14/10/2025

Easy and interactive taxonomic profiling with Metabuli App academic.oup.com/bioinformati... 🧬🖥️🧪 github.com/steineggerla...

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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 21/07/2025

Today at 5pm, @eunbelivable.bsky.social will present her work on the Big Fantastic Viral Database (BFVD) at #ISMB2025 in BOSC. She also has a poster B-123 (tomorrow, 22nd), so please drop by to have ta chat and grab some stickers! 📄 academic.oup.com/nar/article/...

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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 25/04/2025

Visit our posters at #RECOMB2025 for: Structural: MSAs, Virus DB, Core Genes, Motif Discovery, Multimer Clustering & Search, pLM Foldseek, Environmental analysis Metagenomics: Classification & Metabuli App GPU-based & RNA search, Proteome clustering, Novel Ribozyme discovery & get Marv stickers!

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Jaebeom Kim @jbeom.bsky.social · 13/03/2025

Metabuli App preprint is out! 💻Taxonomic classification & interactive visualization—right on your laptop 🛠️Create new databases or update existing ones with new sequences. 🧵1/5 github.com/steineggerla... www.biorxiv.org/content/10.1101/2025.03.10.642298v1

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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 17/01/2025

The Foldseek webserver for fast protein structure searches now features a Sankey tree taxonomy visualization and filter, allowing to subset hits by clades. Developed by my talented student @sunjaelee.bsky.social. Try it out! 🌐 search.foldseek.com

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Jaebeom Kim @jbeom.bsky.social · 30/09/2024

Easy taxonomic profiling with the Metabuli App! Explore your samples with publication-ready Sankey and Krona plots. We accelerated Metabuli further, classifying 2x22M reads vs. GTDB in just 43 min on a MacBook Pro M2. 🧵1/4 🚀https://github.com/steineggerlab/Metabuli-App

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