Background Cystic fibrosis (CF) has profoundly changed since the introduction of CF Transmembrane Conductance Regulator modulator therapies (CFTRmt), a class of medications that improve function of th...

Recent data support the existence of a “gut-lung axis” (GLA), yet it’s role in chronic respiratory diseases, like cystic fibrosis (CF), is under inves…

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The gut microbiome is a key modulator of human health throughout life, from infancy to old age. Within this relatively young field, microbiome charact…

PhD Project - Interrogating microbiomes and metabolomes during P. aeruginosa infiltration and colonisation in CF respiratory tract infection at Manchester Metropolitan University, listed on FindAPhD.c...

Background: Cystic fibrosis (CF) has profoundly changed since the introduction of CF Transmembrane Conductance Regulator modulator therapies (CFTRmt), a class of medications that improve function of t...

Chronic pancreatitis (CP) is a multifaceted and irreversible inflammatory condition that impacts both endocrine and exocrine pancreatic functions. Whilst there is evidence of a general intestinal micr...

Join the GRAMPUS-CF study to explore gut symptoms in cystic fibrosis and help develop personalized treatments. Enroll online or via CF centers.

The influence of NTM infection in pwCF is still debated, and the extent of their contribution to mortality and morbidity is still questioned. Findings in this study highlight a link between the presen...

Background Acute pulmonary exacerbations (PEx) are associated with increased morbidity and earlier mortality for people living with cystic fibrosis (pwCF). The most common causes of PEx in CF are by b...

Nature Medicine - A novel personalized phage therapy strategy that selects phages for a predicted evolutionary trade-off may represent a viable alternative approach for the treatment of...

Research studies have repeatedly demonstrated that chronic lung infection in cystic fibrosis is polymicrobial and consequently does not adhere to the single microbe-based Koch’s postulates. Despite th...

There is a paucity of knowledge on the longer-term effects of CF transmembrane conductance regulator (CFTR) modulator therapies upon the gut microbiom…