iiinova — where your digital self keeps evolving

Reposted by Stan Yatskevich

Przemek Dutka @przemekdut.bsky.social · 08/10/2026

Our latest development is now on bioRxiv: cryoSHIELDs — amphipathic peptide additives that make cryo-EM grid prep far more reliable. Tested across 24 protein systems, they enabled the first ABCC6 structure and GPCR–G protein structures at just 0.1–0.5 mg/mL! www.biorxiv.org/content/10.6...

04526

Reposted by Stan Yatskevich

Dimitry Tegunov @dtegunov.bsky.social · 03/05/2026

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

6313118

Reposted by Stan Yatskevich

Peter Hsu @hsuuperman.bsky.social · 16/04/2026

The culmination of a fantastic collaboration between our lab and Bob Yauch’s lab that resulted in the uncovering of a proteosomal regulatory mechanism for PP2A. Congratulations to all the authors! www.nature.com/articles/s41...

nature.com

Template-driven scaffolding of SCFFBXO42 regulates PP2A degradation - Nature

The E3 ligase SCFFBXO42 degrades holoenzyme-free PP2Ac in complex with the coiled-coil protein CCDC6 to maintain cancer cell fitness

0114

Stan Yatskevich @stanislauy.bsky.social · 02/03/2026

Thrilled to share our new work on how the human RAD51 paralogs cooperate to build and stabilize RAD51 filaments, published today in Nature. www.nature.com/articles/s41... Congratulations to all authors!

nature.com

BCDX2–CX3 and DX2–CX3 complexes assemble and stabilize RAD51 filaments - Nature

Nature - BCDX2–CX3 and DX2–CX3 complexes assemble and stabilize RAD51 filaments

1100

Reposted by Stan Yatskevich

Stephan Gruber @gruberlab.bsky.social · 09/10/2025

How do SMC complexes load onto DNA to get ready for loop extrusion? @roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸‍♂️🤸‍♂️🤸‍♂️. Check out the new paper: www.cell.com/molecular-ce...

39642

Stan Yatskevich @stanislauy.bsky.social · 18/07/2025

The figure was made by @falconierivisuals.bsky.social, so credit for that goes to her

120

Stan Yatskevich @stanislauy.bsky.social · 15/07/2025

We also discovered 4 previously uncharacterised proteins, which we named centromeric subunits 1-4 (CS module), surprisingly repurposed from the outer kinetochore Dam1/DASH complex. It will be very interesting to see how many other species contain this CS module

150

Stan Yatskevich @stanislauy.bsky.social · 15/07/2025

Holocentric kinetochore assembles into a self-contained, head-to-head dimers that entrap and loop DNA, creating a point-centromere-like architecture, suggesting that kinetochores might assemble into such foundational "unit modules" to drive diverse centromere architectures across species

040

Stan Yatskevich @stanislauy.bsky.social · 15/07/2025

Happy to share our latest work on the structure and assembly of holocentric kinetochores! Huge thanks to Ines for a very fruitful collaboration, Claudio for all the support, and congratulations to Christine and all co-authors! www.biorxiv.org/content/10.1...

77224