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Sukjin Steve Jang

@ssjang.bsky.social
148 followers 611 following 7 posts

biophysicist trying to understand how insects smell | Postdoc - del Mármol lab @ Harvard Medical school | PhD - Gonzalez lab @ Columbia University

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Sukjin Steve Jang @ssjang.bsky.social · 26/08/2026
Thank you!!
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Sukjin Steve Jang @ssjang.bsky.social · 25/08/2026
Huge thanks to the team! Sasha Mcdowell, Pramod KC, Marija Simjanoska, Sanjana Mandala, Xiao Zhang, Hanjie Jiang, Phil Cole, Jeff Riffell, Qinheng Zheng, @delmarmollab.bsky.social Read the full updated preprint here: www.biorxiv.org/content/10.1...
biorxiv.org
Molecular logic of pheromone recognition enables rational design of insect behavior modulators
Reproductive success across animal taxa relies on the unequivocal identification of volatile chemical cues used for sexual communication. These chemical signals, called pheromones, are often structura...
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Sukjin Steve Jang @ssjang.bsky.social · 25/08/2026
4/4 Testing in Manduca sexta, these behavior modulators completely abolished odorant receptor response to bombykal—disrupting the males' ability to track female pheromone plumes.
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Sukjin Steve Jang @ssjang.bsky.social · 25/08/2026
3/4 We asked: Could we target this unique chemical reactivity to design selective small-molecule inhibitors? The idea was simple: design electrophiles that lock up the binding pocket and permanently block pheromone binding.
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Sukjin Steve Jang @ssjang.bsky.social · 25/08/2026
2/4 A few years ago we set out to characterize the insect olfactory system at near-atomic resolution. Along the way, we uncovered a surprising covalent mechanism that male moths use to specifically recognize aldehyde pheromones.
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Sukjin Steve Jang @ssjang.bsky.social · 25/08/2026
Excited to share our updated preprint on moth pheromone reception! 🧪🦋 Can we leverage structure-based pharmacology to disrupt insect olfactory behavior? We designed small molecule inhibitors that hijack moth pheromone receptors to block mate recognition. A thread 🧵👇
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Nature Portfolio @natureportfolio.nature.com · 03/03/2026
Butterflies and moths are key indicators of functioning and healthy ecosystems. A Review in Nature Reviews Biodiversity describes the evolutionary history of the order Lepidoptera and tracks shifts in researchers’ understanding of the clade in the genomic era. go.nature.com/4r0kbgS 🌍 🧪
This is figure 2, which shows global diversification dynamics of six diverse butterfly families.
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 30/01/2026
FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social. 📄 www.science.org/doi/10.1126/... 🌐 search.foldseek.com/foldmason 💾 github.com/steineggerla...
science.org
Multiple protein structure alignment at scale with FoldMason
Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...
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Ruben Gonzalez @rubenlgonzalez.bsky.social · 10/12/2025
The Gonzalez Lab at Columbia University is seeking a scientific leader! Join us in a Research Scientist position, driving single-molecule, structural, and biochemical studies of translation, translational control, and other RNA-based processes. Apply: apply.interfolio.com/176949
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Sukjin Steve Jang @ssjang.bsky.social · 31/07/2025
A story about a tiny RNA that taught us a whole lot!!
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Del Mármol lab @delmarmollab.bsky.social · 03/06/2025
New preprint in the lab combining what we like best: insects, love, chemistry and the olfactory system! 1/8 www.biorxiv.org/content/10.1...
biorxiv.org
A covalent recognition strategy enables conspecific mate identification
The olfactory system can detect an uncountable number of volatile molecules while retaining the ability to discriminate amongst very similar ones. We identified a unique mechanism employed by insect o...
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Reposted by Sukjin Steve Jang
Ruben Gonzalez @rubenlgonzalez.bsky.social · 12/03/2025
As some of you already know, I was appointed Dean of Science at Columbia in December and began my role on Jan 1. It’s an honor to support our students, postdocs, and faculty—especially in this challenging moment. Science at Columbia is strong. #ColumbiaScience fas.columbia.edu/news/ruben-g...
fas.columbia.edu
Ruben Gonzalez Appointed Dean of Science | Arts & Sciences
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Ruben Gonzalez @rubenlgonzalez.bsky.social · 11/12/2024
Our latest work is out in Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 www.nature.com/articles/s41...
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Shen Tian 田申 @tianshenbio.bsky.social · 05/12/2024
Our miRNA story is now in @science.org ! We found a microRNA, not a protein, that finally solved a long-standing evolutionary mystery of wing coloration in butterflies and moths. (1/n) www.science.org/doi/10.1126/...
science.org
A microRNA is the effector gene of a classic evolutionary hotspot locus
In Lepidoptera (butterflies and moths), the genomic region around the gene cortex is a “hotspot” locus, repeatedly implicated in generating intraspecific melanic wing color polymorphisms across 100 mi...
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Science News @scinews.bsky.social · 24/11/2024
Three must read papers for PhD students. #scisky #PhD #science #research #academicsky 1. The importance of stupidity in scientific research Open Access journals.biologists.com/jcs/article/...
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