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SMT Evidence

@smtevidence.com
28 followers 73 following 26 posts

Helping industry and academic partners generate the evidence they need to successfully bring their new drugs and technologies to market www.smtevidence.com

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SMT Evidence @smtevidence.com · 30/09/2026
The ‘died with’ vs. ‘died of’ measles discussion misses something very important: that death is a cascade. "If we wanted to be literal about it, the cause of death for nearly everyone would be cardiac arrest, since in the end our hearts stop." www.statnews.com/2026/09/25/d... H/T @statnews.com
statnews.com
The ‘died with’ vs. ‘died of’ measles discussion misses something very important
“Arguing over whether someone died ‘with’ or ‘of’ a disease gets us stuck on the last thing that happened.” write two Unbiased Science scientists.
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SMT Evidence @smtevidence.com · 23/09/2026
All the ways a cell can die — and why the variety matters. Scientists are poking holes in established ideas about how cells live and die, and are harnessing these discoveries to fight diseases from cancer to autoimmune conditions. www.nature.com/articles/d41... #celldeath #cellbiology #biology
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SMT Evidence @smtevidence.com · 21/09/2026
The Drugs and Devices Have Been on the Market for Years. But FDA-Ordered Studies Still Aren’t Done. kffhealthnews.org/health-indus... Some great reporting here from @kffhealthnews.org H/T @statnews.com
kffhealthnews.org
The Drugs and Devices Have Been on the Market for Years. But FDA-Ordered Studies Still Aren’t Done. - KFF Health News
To get drugs and devices out faster, the FDA lets companies conduct studies of safety or efficacy after the products are approved. In many cases, such “postmarket” studies are behind schedule or overd...
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SMT Evidence @smtevidence.com · 01/09/2026
New study assesses the prevalence and types of #data sharing statements in a collection of published trials, and whether the data were actually available when they should have been after e-mailing authors for access www.jclinepi.com/article/S089... #datasharing #data #evidence #systematicreviews #OA
jclinepi.com
Data sharing in stepped-wedge cluster randomized trials: suboptimal data availability despite “data available upon request”
Data sharing enhances transparency, facilitates reproducibility, and promotes innovation in health research. For statisticians, access to data from real trials is essential to develop, validate, and r...
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SMT Evidence @smtevidence.com · 16/08/2026
Where you live affects your exposure to cancer-causing substances - and scientists can read these exposures in your DNA. Geographic variation of mutagenic exposures in kidney cancer genomes. www.nature.com/articles/s41... #mutations #genomics #cancer #oncology #personalisedmedicine
nature.com
Geographic variation of mutagenic exposures in kidney cancer genomes - Nature
Whole-genome sequencing of 962 clear cell renal cell carcinomas from 11 countries shows geographic variations in somatic mutation profiles, including a mutational signature of unknown cause in 70% of ...
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SMT Evidence @smtevidence.com · 24/06/2026
Our new research is out now! Factors associated with #vaccination decisions in pregnant women in the UK. Read the full article online at: www.tandfonline.com/doi/full/10.... #OA #openaccess #scopingreview #evidencesynthesis #vaccines #vaccinehesitancy #maternalvaccines HT @cardiffuni.bsky.social
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JAMA @jama.com · 24/04/2026
💡 JAMA Insights: Numeric risk comparisons anchored in patient context may improve shared decision-making and help patients interpret clinical choices. ja.ma/42qgUNS
JAMA Insights: Using Numerical Comparisons to Help Patients Make Choices. Effective conversations are fundamental for shared decision-making. Table: Tools in the Comparison Toolbox with preferred and less informative communication contexts.
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JBI @jbiebhc.bsky.social · 22/03/2026
Qualitative systematic reviews give voice to patients, clinicians. It's not just about numbers, but understanding the 'whys' behind health-related decisions. Find methodological guidance in the JBI Manual for Evidence Synthesis at ow.ly/q5Bz50YrFg2 #JBImethodology
Systematic reviews of qualitative evidence. The JBI logo is displayed against blue background with an abstract suggestion of ripples. The ripples evoke the JBI logo. (The JBI logo depicts a pebble (‘evidence’) dropping into water, symbolising the ripple effect of positive change driven by evidence.)
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Vox @vox.com · 05/02/2026
Research has found that a routine vaccine slows aging and cut dementia risk. www.vox.com/health/47776...
vox.com
We have a miraculous anti-aging vaccine. Why aren’t more people getting it?
Research has found that a routine vaccine slows aging and cut dementia risk.
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Nature @nature.com · 17/01/2026
An analysis of more than one million people in the UK found that two-thirds of people who were vaccine-hesitant during the COVID-19 pandemic went on to get vaccinated go.nature.com/4sKfBFk
go.nature.com
How to improve vaccine uptake: a huge study offers clues
Nature - An analysis of more than one million people in the UK found that two-thirds of people who were vaccine-hesitant during the COVID-19 pandemic went on to get vaccinated.
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SMT Evidence @smtevidence.com · 12/01/2026
An important read on the loss of credibility of the The National Institutes of Health under the Trump regime. www.statnews.com/2026/01/10/n... Via @statnews.com #evidencebasedmedicine #EBM #research #decisionmaking #NIH #medicine #publichealth
statnews.com
The NIH has lost its scientific integrity. So we left
“We can no longer lend our credibility to an organization that has lost its integrity,” write four scientists and administrators who recently resigned from the NIH.
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SMT Evidence @smtevidence.com · 09/01/2026
Understanding Canada's drug approval and reimbursement pathway just got a whole lot easier with the release of this new online explainer from the CDA-AMC. www.cda-amc.ca/drug-systems... #HTA #evidence #HEOR #systematicreviews #regulatory #CDAAMC
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SMT Evidence @smtevidence.com · 20/11/2025
Day 2️⃣ of the @nihr-io.bsky.social Futures, Foresight & Horizon Scanning conference has been absolutely jam-packed with great science! We kicked off with a thought-provoking keynote, followed a great range of talks - from new start-up projects to horizon scanning in the wearables space. #FFHSC
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SMT Evidence @smtevidence.com · 19/11/2025
A fantastic first day today at the @nihr-io.bsky.social Futures, Foresight & Horizon Scanning conference! Really interesting range of talks, and lots of engaging, in-depth insights and methodologies on display. Can’t wait for day two! #FFHSC
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SMT Evidence @smtevidence.com · 07/11/2025
Very excited to be off to the @nihr-io.bsky.social Futures, Foresight & Horizon Scanning conference on 19th-20th November! Looking forward to lots of great talks - the lightning sessions especially sound fantastic ⚡️⚡️⚡️ Please do shout if you are going along - would be great to say hello 👋 #FFHSC25
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SMT Evidence @smtevidence.com · 28/10/2025
A new #systematicreview and #networkmetaanalysis shows that antidepressants differ markedly in their physiological effects, with substantial differences in parameters such as weight, cholesterol, heart rate, blood pressure www.thelancet.com/journals/lan... @thelancet.com #OA #depression #NMA
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SMT Evidence @smtevidence.com · 14/10/2025
Happy Ada Lovelace Day! Enjoy this annual international celebration of the achievements of women in science, technology, engineering and maths (STEM). findingada.com
findingada.com
Ada Lovelace Day – Celebrating the achievements of women in science, technology, engineering and maths
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SMT Evidence @smtevidence.com · 10/10/2025
“The most important thing about #AI isn't its technical capabilities or limitations. The most important thing is the investor story and the ensuing mania that has teed up an economical catastrophe that will harm hundreds of millions or even billions of people.” pluralistic.net/2025/09/27/e...
pluralistic.net
Pluralistic: The real (economic) AI apocalypse is nigh (27 Sep 2025) – Pluralistic: Daily links from Cory Doctorow
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SMT Evidence @smtevidence.com · 08/10/2025
A microsimulation model to estimate the impact of care disruption during the COVID-19 pandemic on breast cancer mortality using an administrative database. www.jclinepi.com/article/S089... Via @jclinepi.bsky.social
jclinepi.com
A microsimulation model based on healthcare pathways to estimate the impact of COVID-19 pandemic–induced delays on breast cancer mortality
This study aimed to develop a microsimulation model to estimate the impact of a care disruption during the COVID-19 pandemic on breast cancer mortality using an administrative database.
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ACOG @acog.org · 22/09/2025
ACOG reaffirms that acetaminophen is safe for managing pain and fever during pregnancy. No reputable studies support suggestions like those in HHS’s recent announcement linking acetaminophen use in pregnancy to autism; in fact, high-quality studies show no such risk. bit.ly/47Wxc59
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NIHR Innovation Observatory @nihr-io.bsky.social · 03/09/2025
🚨Emerging Point-of-Care Testing in Genomics Exploring the development pipeline of genomic POCTs designed to identify variations in the genome & epigenome, supporting diagnosis, prognosis & treatment decisions across clinical areas👉 ow.ly/UB2R50WQcvo @newcastleuni.bsky.social @nihr.bsky.social
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SMT Evidence @smtevidence.com · 14/09/2025
The contribution of conference abstracts in #systematicreviews - "Their inclusion changed the effect estimate in 55.6% and imprecision in 16% of cases when using MIDs. In a few instances, CAs also influenced RoB and inconsistency assessments." www.jclinepi.com/article/S089... @jclinepi.bsky.social
jclinepi.com
Including conference abstracts rarely changed systematic review conclusions: a case study from a living network meta-analysis of COVID-19 treatments
Including conference abstracts (CAs) in systematic reviews (SRs) helps reduce publication bias but raises concerns about reporting quality and reliability. While discrepancies with full publications a...
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Swift Science Writing @swiftsciencewriting.co.uk · 04/09/2025
Most Americans still don’t know that #alcohol can cause #cancer — and the alcohol industry and Trump are working hard to make sure it stays that way by discrediting and burying a new report that offers new evidence of the link between drinking alcohol and dying www.vox.com/health/46008... @vox.com
vox.com
Exclusive: RFK Jr. and the White House buried a major study on alcohol and cancer. Here’s what it shows.
Kennedy wants to “Make America Healthy Again” — but doesn’t want you to see a report that could do just that.
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Science Magazine @science.org · 02/09/2025
In a new #ScienceExpertVoices article, Seth Berkley unravels the arc of vaccine progress. scim.ag/3VrCDBx
Quote by Seth Berkley on a black background, stating: "…one of humanity's most dramatic successes has been the application of science to understand and then decisively intervene to improve...harrowing conditions."
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The Conversation U.S. @us.theconversation.com · 20/08/2025
Most air cleaning devices have not been tested on people, and little is known about their potential harms. Professors of medicine and public health explain:
buff.ly
Most air cleaning devices have not been tested on people − and little is known about their potential harms, new study finds
Manufacturers often make bold claims about how well these technologies work. Better testing would allow consumers and institutions to pick the most effective ones.
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SMT Evidence @smtevidence.com · 20/08/2025
New #research that could help clinical trials avoid early termination. Identifying predictors of early trial termination: a meta-epidemiological study utilising elements of the research ethics committee evaluation. www.jclinepi.com/article/S089... Via @jclinepi.bsky.social
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SMT Evidence @smtevidence.com · 06/08/2025
A really thought-provoking article from @elife.bsky.social about manuscript publication, peer review and who acts as the gatekeepers of publishing: “why are indexers unable to see that peer review can be more than a thumbs up or a thumbs down?” sfdora.org/2025/07/30/s... H/T @hildabast.bsky.social
sfdora.org
Why are indexers unable to see that peer review can be more than a thumbs up or a thumbs down? | DORA
Journals and peer review are unlikely to change for the better if the companies that operate scientific indexes and citation databases continue to stifle innovation. At eLife we believe that the conte...
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Nature Portfolio @natureportfolio.nature.com · 25/07/2025
A Review in Nature Reviews Endocrinology assesses the role of ultra-processed foods in obesity, examining the epidemiological evidence, biological mechanisms and implications for policymakers. go.nature.com/44zGHoO 🍎📃 #medsky 🧪
This is figure 2, which shows physiological pathways underlying the association between ultra-processed dietary patterns and obesity.
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New Scientist @newscientist.com · 20/07/2025
In human beings, egg cells need to survive for about five decades, much longer than most other cell types – and they may achieve this unusually long lifespan by slowing down their natural cell processes.
newscientist.com
How human eggs stay fresh for decades
In human beings, egg cells need to survive for about five decades, much longer than most other cell types – and they may achieve this unusually long lifespan by slowing down their natural cell processes
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ZB MED - Informationszentrum Lebenswissenschaften @zbmed.bsky.social · 12/06/2025
#SupportOLSPub - every vote counts The first giant steps have been taken, the OLSPub application has been submitted. For all those who, as researchers, information specialists or simply as people, would like to position themselves, everyone can leave a signature here. blog.zbmed.de/olspub-support
blog.zbmed.de
OLSPub support – ZB MED-Blog
Support for the project OLSPub - Open Life Science Publications Database as individuals.
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Eric Topol @erictopol.bsky.social · 04/06/2025
The MAHA report critique, by @hiltzikm.bsky.social www.latimes.com/business/sto... And the Trojan horse, by @drjengunter.bsky.social vajenda.substack.com/p/hijacking-...
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Eric Topol @erictopol.bsky.social · 01/06/2025
The remarkable benefit of exercise was just extended to improved survival after cancer in a randomized trial @nejm.org nejm.org/doi/full/10....
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SMT Evidence @smtevidence.com · 29/05/2025
In the wake of several countries legalising #marijuana, questions remain about the drug's long-term #health effects. A new study has found that people who smoke weed or use edibles do worse on measures of vascular health that predict cardiovascular risk. jamanetwork.com/journals/jam... @jama.com
jamanetwork.com
Endothelial Dysfunction and Chronic Cannabis Use
This cross-sectional study aims to determine whether cannabis use is associated with vascular endothelial function.
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SMT Evidence @smtevidence.com · 23/05/2025
A scoping review of carbon emissions associated with clinical trials finds that several trial activities, including travel and meetings, trial facilities, and sample & lab activities, are consistently carbon heavy. www.jclinepi.com/article/S089... @jclinepi.bsky.social #scopingreview #openaccess
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SMT Evidence @smtevidence.com · 18/05/2025
Brand new SPIRIT and CONSORT #reporting #guidelines are out now! 🎯 CONSORT 2025 for reporting RCTs now has a 30-item checklist 🎯 SPIRIT 2025 for reporting trial protocols now has a 34-item checklist www.jclinepi.com/article/S089... @jclinepi.bsky.social #SPIRIT #CONSORT #RCTs #protocols
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Journal of Clinical Epidemiology @jclinepi.bsky.social · 17/05/2025
What makes a good guideline? – A systematic review and analysis of 120 clinical practice guidelines using the AGREE II tool - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
jclinepi.com
What makes a good guideline? – A systematic review and analysis of 120 clinical practice guidelines using the AGREE II tool
Clinical practice guidelines (CPGs) translate evidence into actionable recommendations to enhance care quality, improve clinical outcomes, reduce treatment variations, and make healthcare delivery mor...
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SMT Evidence @smtevidence.com · 11/05/2025
A new reporting guideline has just been published for the involvement of patients and caregivers in identifying and designing healthcare interventions: the IDEAS framework www.jclinepi.com/article/S089... HT @jclinepi.bsky.social #OA #openaccess #IDEAS #coproduction #patients #partners #research
A diagram with seven blue circles describing the different items within a patient-researcher research cycle. The seven blue circles include: designing and managing, undertaking, disseminating, implementing, evaluating impact, prioritising and commissioning
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The Lancet @thelancet.com · 25/04/2025
The RTS,S/AS01E malaria vaccine has been successfully administered to over 2 million children since 2019. On #WorldMalariaDay, a paper in @lancetgh.bsky.social reports the results of a study evaluating RTS,S/AS01E safety and effectiveness in real-world settings: tinyurl.com/3jthn39h
Research in context panel for The Lancet Global Health article "Safety of RTS,S/AS01E malaria vaccine up to 1 year after the third dose in Ghana, Kenya, and Malawi (EPI-MAL-003): a phase 4 cohort event monitoring study". Copyright: 2025 GSK plc. Published by Elsevier Ltd. CC By 4.0.
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The Health Foundation @healthfoundation.bsky.social · 16/04/2025
Electronic patient records (EPRs) can potentially transform health care delivery, improving quality, efficiency and patient safety. Most trusts in England now have EPRs but many are not yet using them to their full potential. We explored the challenges in our recent analysis ⬇️
bit.ly
Electronic patient records: why the NHS urgently needs a strategy to reap the benefits
Our qualitative research with five acute NHS trusts and a US medical centre investigates the current state of EPR adoption and use, and what it takes to really see the benefits.
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SMT Evidence @smtevidence.com · 15/04/2025
Out of the top 25 most-cited papers in the 21st century, the #PRISMA statement comes in at number 6 with a mind-boggling 133,965 citations according to Web of Science. www.nature.com/articles/d41... H/T @nature.com #systematicreviews #evidence #evidencesynthesis #statistics #data #citations
nature.com
Exclusive: the most-cited papers of the twenty-first century
A Nature analysis reveals the 25 highest-cited papers published this century and explores why they are breaking records.
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Swift Science Writing @swiftsciencewriting.co.uk · 24/03/2025
Large language models for conducting systematic reviews: on the rise, but not yet ready for use—a scoping review. "Although LLMs show promise in supporting SR creation, fully established or validated applications are often lacking" www.jclinepi.com/article/S089... via @jclinepi.bsky.social #AI #LLM
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SMT Evidence @smtevidence.com · 01/04/2025
A new study from @jclinepi.bsky.social explores methods for retrieving publications not indexed in PubMed and Embase, examining coverage of various specialties to determine the most effective search strategies for systematic reviews. www.jclinepi.com/article/S089... #OA #searches #evidence #SLR
jclinepi.com
Supplementary databases increased literature search coverage beyond PubMed and Embase
In health sciences, comprehensive literature searches are crucial for ensuring the accuracy and completeness of systematic reviews. Relying on only a few databases can lead to the omission of relevant...
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