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Sakari Mäntyselkä

@smantyselka.bsky.social
56 followers 56 following 20 posts

PhD in Exercise Physiology. MSc in Cell and Molecular Biology. Interested in metabolism, muscle biology, and bioanalytics (e.g. metabolomics). Orcid: orcid.org/0000-0002-2313-0735

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Reposted by Sakari Mäntyselkä
Craig A. Goodman @craigagoodman1.bsky.social · 13/07/2026
Mechanical Loading Induces Distinct and Shared Responses in Endothelial and Muscle Cells and Reveals Exercise-Like Molecular Profiles faseb.onlinelibrary.wiley.com/doi/10.1096/...
faseb.onlinelibrary.wiley.com
Mechanical Loading Induces Distinct and Shared Responses in Endothelial and Muscle Cells and Reveals Exercise‐Like Molecular Profiles
Mechanical loading of human endothelial and muscle cells induced several distinct and shared molecular responses, many of which are commonly observed after exercise in vivo. Both cell types secreted ...
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Sakari Mäntyselkä @smantyselka.bsky.social · 06/07/2026
Nice to see that in-press version of our mini-review entitled "Skeletal muscle biomass as an under appreciated fate of glucose" is now available. Thanks for the collaboration Henning Wackerhage, @moritzeggelbusch.bsky.social and @juhahulmi.bsky.social! #myoblue
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Sakari Mäntyselkä @smantyselka.bsky.social · 23/05/2026
This was a fantastic conference, and at first glance, this review article looks great too! #myoblue
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Reposted by Sakari Mäntyselkä
DFG-funded HyperMet Research Unit (FOR 5795) @hypermet.bsky.social · 10/04/2026
On the 16th of April join the talk by Jared Rutter on “The Language of Metabolic Signalling,” which explores how metabolites act as signalling molecules and building blocks, not just fuels. Here is the MS teams link: teams.microsoft.com/meet/3325843...
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Sakari Mäntyselkä @smantyselka.bsky.social · 24/10/2025
Our new preprint suggest that in vitro mechanical cyclic stretching alone induces many similar molecular responses as exercise in vivo.
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Sakari Mäntyselkä @smantyselka.bsky.social · 11/10/2025
I am pleased to share our new research article (in press version) entitled Glycolytic metabolism and biomass production from glucose in human skeletal muscle growth. Link in the comments. 1/3 #myoblue #SkeletalMuscle
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Reposted by Sakari Mäntyselkä
University of Jyväskylä | Jyväskylän yliopisto, JYU @uniofjyvaskyla.bsky.social · 11/09/2025
Why do some progress faster in resistance training? 💪 How do genetics and physiology shape training responses? 🏋️‍♀️ Join us in Jyväskylä, Finland, Nov 19–21 for the Inter-Individual Variation in Resistance Training Responses Conference. www.jyu.fi/en/news/indi...
jyu.fi
Individual responses to exercise training as the main theme of an international conference in Jyväskylä, November 19–21, 2025
Why do some people progress faster in exercise training than others? How can training responses be predicted, and how does genetics influence the outcomes of training? These questions are addressed at the international coaching science conference.
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Sakari Mäntyselkä @smantyselka.bsky.social · 03/09/2025
Eli Lilly in $650M pact to boost muscle #myoblue www.nature.com/articles/s41...
nature.com
Eli Lilly in $650M pact to boost muscle - Nature Biotechnology
Nature Biotechnology - Eli Lilly in $650M pact to boost muscle
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Sakari Mäntyselkä @smantyselka.bsky.social · 28/08/2025
I assume that today will be a great talk!
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Reposted by Sakari Mäntyselkä
DFG-funded HyperMet Research Unit (FOR 5795) @hypermet.bsky.social · 16/08/2025
One major, unsolved problem is all those unknown signals in MS metabolomics data. To predict what they are, Mike Skinneder has developed DeeMet. He will give the 17th HyperMet talk next Thursday at 15 h Munich time. Join here (please RT): tum-conf.zoom-x.de/j/6392132327...
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Reposted by Sakari Mäntyselkä
DFG-funded HyperMet Research Unit (FOR 5795) @hypermet.bsky.social · 11/08/2025
Really looking forward to Lykke Sylow given the 16th HyperMet talk this Thursday 15 h. Whe will talk about the effect of hypertrophy stimulation on fat mass and glucose homeostasis (recent preprint). Please RT and join here: tum-conf.zoom-x.de/j/6903199711...
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Sakari Mäntyselkä @smantyselka.bsky.social · 03/07/2025
Our pre-print is now available 🤓
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Reposted by Sakari Mäntyselkä
Juha Hulmi @juhahulmi.bsky.social · 02/07/2025
Conference: Inter-individual variation in exercise. Please join! The speakers are e.g. @mackinprof.bsky.social, @abigailmackey1.bsky.social, M Bamman, T Hornberger, M Roberts, B Schoenfeld, M Perola, G Nader, E Sillanpää, A Hecksteden, W Derave, P Atherton, J Ahtiainen and me. tinyurl.com/34xzsdss
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Sakari Mäntyselkä @smantyselka.bsky.social · 28/06/2025
#myoblue
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Sakari Mäntyselkä @smantyselka.bsky.social · 27/06/2025
A comparison of human skeletal muscle cell maturation in 2D versus 3D culture: A quantitative proteomic study. #myoblue physoc.onlinelibrary.wiley.com/doi/10.14814...
physoc.onlinelibrary.wiley.com
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Reposted by Sakari Mäntyselkä
Craig A. Goodman @craigagoodman1.bsky.social · 17/06/2025
The commonly used antibiotic streptomycin reduces protein synthesis and differentiation in cultured C2C12 myotubes physoc.onlinelibrary.wiley.com/doi/10.14814...
physoc.onlinelibrary.wiley.com
The commonly used antibiotic streptomycin reduces protein synthesis and differentiation in cultured C2C12 myotubes
The antibiotic streptomycin is an integral part of cell culture medium. Because streptomycin inhibits bacterial protein synthesis, streptomycin might also have off-target effects on muscle cell funct...
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Sakari Mäntyselkä @smantyselka.bsky.social · 10/06/2025
Very interesting study! Congratulations!
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Reposted by Sakari Mäntyselkä
APS Publications @apspublications.bsky.social · 03/06/2025
This review highlights the molecular mechanisms that regulate glucose utilization in skeletal muscle, the primary site of glucose storage and oxidation. Erik A. Richter, et al. doi.org/10.1152/phys... #GlucoseMetabolism #InsulinSensitization
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Reposted by Sakari Mäntyselkä
Anu Suomalainen Wartiovaara @awartiovaara.bsky.social · 16/05/2025
Muscle needs to make serine from glucose to protect the fibers from mitochondrial disease. Read our story, a tour de force of Anastasiia Marmyleva and Christopher Jackson @SWAN @STEMM Helsinki University www.cell.com/cell-reports...
cell.com
De novo serine biosynthesis is protective in mitochondrial disease
Jackson et al. show that serine becomes an essential amino acid in mitochondrial muscle disease, delaying disease progression. Blocking local biosynthesis of serine challenges cellular phospholipid ho...
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Sakari Mäntyselkä @smantyselka.bsky.social · 15/05/2025
I look forward to the results of the human clinical trial in the future! Very interesting research area! clinicaltrials.gov/study/NCT056...
clinicaltrials.gov
ClinicalTrials.gov
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Reposted by Sakari Mäntyselkä
Abigail Mackey @abigailmackey1.bsky.social · 13/05/2025
Considerations of working with human primary muscle cells - happy to have contributed to this important topic. Thank you Tom Francis and Steve Harridge for inviting me and Casper Soendenbroe to join you! link.springer.com/article/10.1...
link.springer.com
Insights into human muscle biology from human primary skeletal muscle cell culture - Journal of Muscle Research and Cell Motility
This review arises from the symposium held in honour of Prof Jenny Morgan at UCL in 2024 and the authors would like to acknowledge the outstanding contribution that Prof Morgan has made to the field o...
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Sakari Mäntyselkä @smantyselka.bsky.social · 14/05/2025
I can fully recommend Juha Hulmi! I am a final year PhD student in Juha's group.
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Reposted by Sakari Mäntyselkä
Rafeeque Mavoor @rafeequemavoor.bsky.social · 13/05/2025
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!
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Reposted by Sakari Mäntyselkä
Juha Hulmi @juhahulmi.bsky.social · 05/04/2025
Excited to share this! We found that muscles "remember" at the proteome level that they have been training. We also report quite reproducible proteome response to resistance training. physoc.onlinelibrary.wiley.com/doi/full/10.... @jphysiol.bsky.social @varjosal.bsky.social
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Reposted by Sakari Mäntyselkä
Bluesky @bsky.app · 03/12/2024
Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪
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Sakari Mäntyselkä @smantyselka.bsky.social · 22/11/2024
Great study by my PhD supervisor Juha Hulmi and my colleague PhD student Eeli Halonen and their team and collaborators like @varjosal.bsky.social et al! "Human skeletal muscle possesses both reversible proteomic signatures and a retained proteomic memory..." #myoblue www.biorxiv.org/content/10.1...
biorxiv.org
Human skeletal muscle possesses both reversible proteomic signatures and a retained proteomic memory after repeated resistance training
Investigating repeated resistance training separated by a training break enables exploration of the potential for a proteomic memory of skeletal muscle growth. Our aim was to examine skeletal muscle p...
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Sakari Mäntyselkä @smantyselka.bsky.social · 22/11/2024
Very interesting and great study by Horberger Lab and their collaborators! "Identification of a Resistance Exercise-Specific Signaling Pathway that Drives Skeletal Muscle Growth" www.researchsquare.com/article/rs-4... #myoblue
researchsquare.com
Identification of a Resistance Exercise-Specific Signaling Pathway that Drives Skeletal Muscle Growth
A human model of unilateral endurance versus resistance exercise, in conjunction with deep phosphoproteomic analyses, was used to identify exercise mode-specific phosphorylation events. Among the outc...
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