The results are astounding and a major advance, say surgeons involved in international research using the pioneering technology.

Kaiser et al. characterize the disordered extracellular N-terminus of a peptide-activated G protein-coupled receptor. They combine biophysical, biochemical, and computational methods to uncover its role in the activation of G protein and arrestin pathways.

The GAIN domain of adhesion G protein-coupled receptors, a class of biological mechanosensors, was thought to be sufficient for its self-cleavage. Here, the authors show that the event also depends on the seven-transmembrane region of the receptors.

Previous efforts in delineating molecular mechanisms of G protein-coupled receptor (GPCR) activation have focused on transmembrane regions and ligand-receptor contacts of the extracellular loops. The ...

Trump’s most brazen attack on free speech yet.

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Julius-Maximilians-Universität Würzburg bietet Stelle als Universitätsprofessorin / Universitätsprofessor (m/w/d) für Pflanzengenetik (W3) in Würzburg - jetzt bewerben!

A video from Andrea Sinz, posted on Aug 14, 2025.

Job offer Mass Spectrometry Technology Specialist, Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie, Warszawa

Registration will be open until the 31st of July. Detailed information and a preliminary schedule will be announced in due time. There is no registration fee for the conference. Room reservations at t...

I agree that faith is essential to success in life (success of any sort) but I do not accept your […]

Infectious diseases have had devastating effects on human populations throughout history, but important questions about their origins and past dynamics remain1. To create an archaeogenetic-based spatiotemporal map of human pathogens, we screened shotgun-sequencing data from 1,313 ancient humans covering 37,000 years of Eurasian history. We demonstrate the widespread presence of ancient bacterial, viral and parasite DNA, identifying 5,486 individual hits against 492 species from 136 genera. Among those hits, 3,384 involve known human pathogens2, many of which had not previously been identified in ancient human remains. Grouping the ancient microbial species according to their likely reservoir and type of transmission, we find that most groups are identified throughout the entire sampling period. Zoonotic pathogens are only detected from around 6,500 years ago, peaking roughly 5,000 years ago, coinciding with the widespread domestication of livestock3. Our findings provide direct ev