The results are astounding and a major advance, say surgeons involved in international research using the pioneering technology.

Kaiser et al. characterize the disordered extracellular N-terminus of a peptide-activated G protein-coupled receptor. They combine biophysical, biochemical, and computational methods to uncover its role in the activation of G protein and arrestin pathways.

The GAIN domain of adhesion G protein-coupled receptors, a class of biological mechanosensors, was thought to be sufficient for its self-cleavage. Here, the authors show that the event also depends on the seven-transmembrane region of the receptors.

Previous efforts in delineating molecular mechanisms of G protein-coupled receptor (GPCR) activation have focused on transmembrane regions and ligand-receptor contacts of the extracellular loops. The ...

Trump’s most brazen attack on free speech yet.

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Julius-Maximilians-Universität Würzburg bietet Stelle als Universitätsprofessorin / Universitätsprofessor (m/w/d) für Pflanzengenetik (W3) in Würzburg - jetzt bewerben!

A video from Andrea Sinz, posted on Aug 14, 2025.