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Simon Lewis

@simon-e-lewis.bsky.social
208 followers 295 following 17 posts

Organic chemistry professor at the University of Bath ORCID: 0000-0003-4555-4907

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Simon Lewis @simon-e-lewis.bsky.social · 23/12/2025
🧪 PhD Opportunity (UK/international) with Simon Lewis & James Taylor at the University of Bath: “Radicals on Demand from Sulfonium Salt Electron Donor-Acceptor Complexes” Electrosynthesis ⚡ + photochemistry 💡. See: bit.ly/4qjBsS3 **DEADLINE 8TH FEB** #chemistry #phd #orgchem @bathchem.bsky.social
Reaction scheme showing generation of a radical from a thianthrenium salt electron-donor-acceptor complex
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Simon Lewis @simon-e-lewis.bsky.social · 26/11/2025
Great working with Suresh Awale and his team at University of Toyama, who have carried out further biological evaluation of a natural product analogue "grandifloridin D". It exhibits "anti-austerity" activity against pancreatic cancer cell lines in vitro @bathchem.bsky.social doi.org/10.1248/bpb....
Graphical abstract showing structure of grandifloridin D and its key biological targets
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Simon Lewis @simon-e-lewis.bsky.social · 26/11/2025
Happy to share that our review on TICT-based fluorescent probes is now published in @chemsocrev.rsc.org - great working with this team including @chemosensors.bsky.social at @bathchem.bsky.social doi.org/10.1039/D3CS...
doi.org
Twisted intramolecular charge transfer (TICT) based fluorescent probes and imaging agents
Twisted Intramolecular charge transfer (TICT)-based fluorescent probes are crucial in chemical sensing due to their sensitivity and specificity. These probes undergo conformational changes upon intera...
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Simon Lewis @simon-e-lewis.bsky.social · 12/09/2025
#chem25 at @bathchem.bsky.social is underway - Jennifer Carlisle (née Peed) giving her talk and reminiscing about her PhD days…
Jenny Carlisle giving her talk at the chem25 event in Bath
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Simon Lewis @simon-e-lewis.bsky.social · 05/09/2025
Come and be our colleague at @bathchem.bsky.social - we are recruiting to a (permanent) faculty position in AI/Machine Learning for Drug Discovery #chemjobs #facultychemjobs DEADLINE 30th Sep - For details see: www.bath.ac.uk/jobs/Vacancy...
bath.ac.uk
AP13001 Lecturer in AI/ML applied to Drug discovery - Jobs at Bath
Lecturer
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Simon Lewis @simon-e-lewis.bsky.social · 29/07/2025
Congratulations to former PhD student Emily Pocock, whose work at @bathchem.bsky.social on Methanimine hetero-Diels-Alder reactions has just been published in JOC: doi.org/10.1021/acs....
doi.org
Intercepting Methanimine for the Synthesis of Piperidine-Based N-Heterocycles in an Aqueous Medium
We herein present an investigation into whether simple methodology could be used to intercept the highly reactive interstellar molecule methanimine. The use of an in situ aza-Diels–Alder reaction to t...
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Reposted by Simon Lewis
Russell Cox Chem @russellcoxchem.bsky.social · 22/07/2025
A new fluorescent amino acid, built into an unprecedented cytochalasan that possesses potent bioactivity…. See our latest work at pubs.rsc.org/en/content/a...
pubs.rsc.org
Synthesis of L-β-(6-azulenyl)alanine and the fluorescent actin disruptor (6-azuleno)chalasin H
l-β-(6-Azulenyl)alanine was synthesised for the first time. Supplementation of this compound to Pyricularia grisea ΔpyiA led to the biosynthesis of the unnatural (6-azuleno)chalasin H and its 1′-bromo...
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University of Bath Chemistry @bathchem.bsky.social · 13/07/2025
🧪 Celebrating 25 years of Chemistry in 1 South at the University of Bath 🎉 Talks from alumni + familiar faces, then food + music as the sun sets. 🌇 Good vibes. Great people. 📆 Register by Sept 1 💷 £20 / £10 (students) thanks to our sponsors 🙌 🔗 www.chem25.co.uk #Chem25 #UniOfBath #Chemistry
chem25.co.uk
Chem25@Bath | 25 Years of Discovery, Innovation & Community in 1 South
Chem25: Marking 25 Years of Innovation in the 1 South Chemistry Building, University of Bath
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Tony D. James 👨‍🔬 (He, Him, His) @chemosensors.bsky.social · 25/06/2025
The 8th International Conference on Molecular Sensors and Molecular Logic Gates (MSMLG 2025) is scheduled to be held from 9th to 12th October 2025 in Shanghai, China. Registration is open and we have a great line-up of confirmed speakers already msmlg2025.ecust.edu.cn/index.html
msmlg2025.ecust.edu.cn
The 8th Molecular Sensor and Molecular Logic Gate
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Simon Lewis @simon-e-lewis.bsky.social · 23/06/2025
Come and be our colleague at @bathchem.bsky.social! 2-year fixed-term teaching position - computational and physical chemistry, deadline 15th July #chemjobs: www.bath.ac.uk/jobs/Vacancy...
bath.ac.uk
AP12810 Lecturer in Physical and Computational Chemistry - Jobs at Bath
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Charlie McTernan @charliemcternan.bsky.social · 19/06/2025
Correct link - www.crick.ac.uk/careers-stud...
crick.ac.uk
Postdoctoral Project Research Scientist
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Perry Group @perrychem.bsky.social · 27/05/2025
Last few days to apply! Deadline: Thursday 29th May.
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Simon Lewis @simon-e-lewis.bsky.social · 21/05/2025
Our latest paper at @bathchem.bsky.social is on a biazulene analogue of BINOL - click here to read! doi.org/10.1039/D5RA...
doi.org
Synthesis and resolution of a 1,1′-biazulene analogue of BINOL
Biaryls exhibiting axial chirality have been extensively exploited in fields such as asymmetric catalysis, but the biaryl linkage typically consists of benzenoid aromatic rings, with non-benzenoid bia...
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Simon Hammann @simonhammann.bsky.social · 12/04/2025
Oh? What was that? You want to know if titles are important in Germany?
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Simon Lewis @simon-e-lewis.bsky.social · 01/04/2025
Great to former @bathchem.bsky.social PhD student Leah White's doctoral work out in the literature: doi.org/10.1038/s414...
doi.org
Enantiopure synthesis of [5]helicene based molecular lemniscates and their use in chiroptical materials - Nature Communications
The ability to synthesise lemniscular molecules to allow for the study and application of their chiroptical properties is a notable technical challenge. Herein, the authors report the design and synth...
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Simon Lewis @simon-e-lewis.bsky.social · 05/03/2025
Just out: perspective in JACS on fluorescent probes for liver diseases, with @chemosensors.bsky.social, Robin Groleau and Luling Wu at @bathchem.bsky.social, Zilu Li, Baocun Zhu and their teams at Jinan (free to read): doi.org/10.1021/jacs...
doi.org
Advances in Organic Small Molecule-Based Fluorescent Probes for Precision Detection of Liver Diseases: A Perspective on Emerging Trends and Challenges
Liver disease poses a significant challenge to global health, and its early diagnosis is crucial for improving treatment outcomes and patient prognosis. Since fluctuation of key biomarkers during the ...
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Stephen Husbands @stevehusbands.bsky.social · 01/03/2025
Difficult to give timely harm reduction advice if you don't know what you are dealing with. This will help: pubs.acs.org/doi/10.1021/...
pubs.acs.org
Field-Portable Device for Detection of Controlled and Psychoactive Substances from e-Cigarettes
Synthetic cannabinoids (SCs) are novel psychoactive substances (NPS) that are highly potent and associated with a range of severe toxicities. SC use, which is common in UK prisons and homeless communi...
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Newcastle Chemistry @chemistryncl.bsky.social · 05/02/2025
Yesterday, after 34+ years of excellence in teaching & research, Dr Julian Knight gave his last organic lecture at Newcastle. Then this happened...😍 Thanks so much to Julian, and all the staff and students that turned out to wish him well in his retirement! #WeAreNCL
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Bath Institute of Sustainability and Climate Change (ISCC) @bath-iscc.bsky.social · 30/01/2025
🌍Today marks the official launch of @bath-iscc.bsky.social ! Against the background of the triple planetary crisis of #climatechange, #pollution and #biodiversityloss, the Institute’s launch could not be more timely. At the heart of our mission are 7 key strengths that define who we are:
Multidisciplinary: We have over 50 core members and a wider academic community representing every Faculty and School at the University of Bath. 

By breaking down disciplinary silos, our aim is to lead transformative research across three core themes:

Sustainable Chemical Technologies: Designing and deploying sustainable molecules, materials and manufacturing processes

Sustainable Systems: Measuring sustainability in decision making
 
Social Transformations: Enabling equitable, societal shifts toward sustainabilityAcademically renowned: Our researchers secure significant grant funding, enabling us to undertake ambitious research, attract top talent, and deliver innovations that tackle the most pressing sustainability challenges of our time.

In 2023-24, core members achieved approximately £21 million 
           in grant funding
Research published in leading international journals by our 50+ core members received approximately 4,000 online views and 650 citations in 2023-24
Our members lead high-profile national and international research consortia
We convene global research conferences, workshops, and events
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Douglas Philp @profphilp.bsky.social · 08/01/2025
Now that 2025 is here, just wanted to highlight the opening we have for an Organic Chemistry Lectureship at St Andrews again. Applications close in about two weeks on 22nd January. All the details in the link. www.vacancies.st-andrews.ac.uk/V2/ViewVacan...
vacancies.st-andrews.ac.uk
Lecturer in Organic Chemistry - AC2577LS
Lecturer in Organic Chemistry - AC2577LS, School of Chemistry Salary: £46,485 - £56,921 per annum (£46,735 - £57,422pa from March 2025) Start Date: August 2025, <p style="text-align: justify;"><span...
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Stu Cantrill @stuartcantrill.com · 07/12/2024
Indeed. Good job taking photos wasn’t forbidden 😉
A picture of Fraser Stoddart standing next to a poster saying ‘Taking photos is forbidden’
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Ulrich Hintermair @hintermairlab.bsky.social · 27/12/2024
Learn about cutting-edge reaction monitoring techniques and physico-chemical methods for revealing and understanding hidden complexities in solution-phase chemistry and catalysis: Come and join us @uniofbath.bsky.social on the 28th January 2025 for our 6th Reaction Monitoring Symposium!
eventbrite.co.uk
Reaction Monitoring Symposium 2025
The 6th Reaction Monitoring Symposium will be of interest to those studying chemical reactions and processes, in academia or industry.
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Ulrich Hintermair @hintermairlab.bsky.social · 20/12/2024
📣 #chemsky #phdjobs: We have got ANOTHER PhD project @dreamfacility.bsky.social @bath-iscc.bsky.social for 2025, this time with @syngenta.bsky.social! Interested in #FlowNMR and catalytic reaction mechanisms? Look no further and work at the leading edge: www.findaphd.com/phds/project...
findaphd.com
FlowNMR reloaded: better knowledge extraction from real-time spectroscopy data at University of Bath on FindAPhD.com
PhD Project - FlowNMR reloaded: better knowledge extraction from real-time spectroscopy data at University of Bath, listed on FindAPhD.com
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Simon Lewis @simon-e-lewis.bsky.social · 16/12/2024
Excited to be at #MASC2024, day 1 just getting underway. First talk from Prof. Duncan Bruce on fluorous liquid crystals…
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Morrill Group @morrillgroup.bsky.social · 11/12/2024
3.5-year PhD studentship (open to UK and international students, starting Sept/Oct 2025) for a collaborative project between our group and @LuptonChemistry investigating the combination of organic electrochemistry and organocatalysis for synthesis! www.findaphd.com/phds/project...
findaphd.com
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Simon Lewis @simon-e-lewis.bsky.social · 09/12/2024
Read our feature review on C-C bond forming reactions using aromatics from biomass - great collaboration with @kannlab.bsky.social!! @bathchem.bsky.social @bath-iscc.bsky.social #ChemSky #sustainability doi.org/10.1039/D4CC...
doi.org
Carbon–carbon bond formation using aromatics from biomass
The transition to a circular economy requires that we adapt currently used chemical processes to the structurally diverse and often highly oxygenated precursors that are accessible from biomass. In th...
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Marina Uzelac @marinauzelac.bsky.social · 03/12/2024
Very proud to share our team’s first paper 📝 #Bath chemistry! Many congratulations to Rebecca on doing such an amazing job tackling some tricky #manganese complexes in her #year1 💪 #proudsupervisor Thanks to the RS for the support #URF #newPI chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com
Structural Diversity in Homoleptic Lithium Amidomanganate(II) Complexes: Impact of Amine Substitution
Expanding the library of structurally characterized lithium amidomanganates(II), here we report a general synthetic approach to access a new series of homoleptic complexes. In situ salt-metathesis of...
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David K Smith @professor-dave.bsky.social · 29/11/2024
Today is the final day to register for #MASC2024 in York - we have a great meeting lined up on December 16/17 with an array of leading supramolecular chemists. mascgroup.co.uk/masc2024/
mascgroup.co.uk
MASC 2024
Home Programme Speakers Registration & Bursaries Abstract Submission Venue Travel Accommodation Sponsors RSC Macrocyclic and Supramolecular Chemistry Meeting University of York 16th–17th Decemb…
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Bela Bode @belab.bsky.social · 28/11/2024
@uniofstandrews.bsky.social looking to hire a lecturer in organic chemistry. A fantastic place to work with wonderful students and colleagues. www.jobs.ac.uk/job/DKW116/l... 🧪 ⚗️ #chemsky
jobs.ac.uk
Lecturer in Organic Chemistry - AC2577LS at University of St Andrews
An academic position as a Lecturer in Organic Chemistry - AC2577LS is being advertised on jobs.ac.uk. Click now to find more details and explore additional academic job opportunities.
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Simon Lewis @simon-e-lewis.bsky.social · 27/11/2024
Latest paper on non-benzenoid #azulene fluorophores is a collaboration with Hua Zhang and @chemosensors.bsky.social - two-photon imaging of carboxylesterase activity #PiSky #ChemSky @uniofbath.bsky.social doi.org/10.1021/acs....
doi.org
Amphiphilic Azulene-Based Fluorescent Probe for Simultaneous Monitoring of Fluctuations in Carboxylesterase Activity in Diverse Biological Samples from a Single Organism
Carboxylesterase (CEs), as a key enzyme in ester metabolism, is simultaneously found with varying expression levels in diverse biological samples from a single organism, such as tissues, cells, bacter...
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Simon Lewis @simon-e-lewis.bsky.social · 26/11/2024
Hey #PiSky #ChemSky, take a look at this paper from my colleague Uli Hintermair on a rt-stable antiaromatic pentalene! doi.org/10.1039/D4SC06439A
doi.org
Reversible formation of tetraphenylpentalene, a room temperature stable antiaromatic hydrocarbon
1,3,4,6-tetraphenylpentalene (Ph4Pn) has been synthesised by chemical oxidation of the corresponding pentalenide complex Mg[Ph4Pn] with iodine. Ph4Pn is a rare example of a room-temperature stable hyd...
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Tony D. James 👨‍🔬 (He, Him, His) @chemosensors.bsky.social · 25/11/2024
pubs.acs.org/doi/10.1021/...
pubs.acs.org
Fluorescent Chemosensors in the Creation of a Commercially Available Continuous Glucose Monitor
Fully automated insulin delivery (i.e., an artificial pancreas) would revolutionize diabetes disease management, minimize negative secondary disease outcomes, and simultaneously reduce health care cos...
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Nessa Carson @supersciencegrl.co.uk · 23/11/2024
Now Reading chemistry department isn't merging with pharmacy any more... www.linkedin.com/posts/christ...
linkedin.com
Christine Cardin on LinkedIn: Dear all, many thanks for the support. As I have rapidly realised, it is…
Dear all, many thanks for the support. As I have rapidly realised, it is the existence of the Chemistry Department as a unit which matters most of all to so…
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Pablo Gómez Barreiro @pagomba.bsky.social · 22/11/2024
Our recently peer-reviewed paper on the current Strain on Scientific Publishing is covered by The @economist.com today. I'm not surprised by Frontiers and MDPI continuing to champion the virtues of rapid publishing. 🧪 www.economist.com/science-and-... QSS paper here: direct.mit.edu/qss/article/...
economist.com
Scientific publishers are producing more papers than ever
Concerns about some of their business models are building
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Thorn-Seshold Lab @thornsesholdlab.bsky.social · 22/11/2024
Wishing the Elsevier editors who desk-accepted this all the best for their next career moves. doi.org/10.1016/j.ij...
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Simon Lewis @simon-e-lewis.bsky.social · 22/11/2024
Really pleased that the latest (and final) paper from Jodie Hann's PhD work @uniofbath.bsky.social has now been published. Read about how pyrrolyl sulfonium salts can be used for the cross-coupling of pyrroles where pyrrolyl halides fail: doi.org/10.1039/d4qo...
doi.org
Pyrrolylsulfonium salts: stable, accessible and versatile pseudohalides for Stille couplings
Pyrrolyl halides can be difficult to synthesise in a regioselective manner and are often unstable, which has hampered their application in cross-coupling. Here we introduce pyrrolylsulfonium salts as ...
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shenvi.bsky.social @shenvi.bsky.social · 18/11/2024
If you like total synthesis and Wordle, check out Synthordle, a retrosynthetic analysis game created by Shenvi Lab associates Kevin Zong (GS 2) and Jonah Luo (HS sophomore!). shenvilab.github.io/Synthordle/ Easy problems for Sophomore OChem, hard problems for advanced practitioners.
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Michael Booth @drmikebooth.bsky.social · 23/08/2024
This needed to be on chemsky
Can I lick it version of the periodic table
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