Sihao Lu @sihaolu.bsky.social · 24/07/2026Checkout this great work by Jingkun; multiplexed 2-photon voltage imaging. Choose either a huge FOV or multiple depths near-simultaneously! 010
Sihao Lu @sihaolu.bsky.social · 06/07/2026Amazing opportunity to work with an excellent mentor on a great project. Cherry on top: it's in Madrid! 001
Reposted by Sihao LuDevelopment @dev-journal.bsky.social · 16/02/2026Axonal defasciculation is restricted to specific branching points during regeneration of the lateral line nerve in zebrafish Read the first #OA article in #DevSIextracellular by Rohan S. Roy and A. J. Hudspeh (@rockefeller.edu) in our Stem Cells and Regeneration section: doi.org/10.1242/dev.... 1164
Sihao Lu @sihaolu.bsky.social · 01/02/2026Delighted to share this piece of my PhD work: Astrocytes and neurons exhibit partially shared but distinct composite receptive fields for natural stimuli. We show that astrocytes have distinct receptive fields and suggest that they play a complimentary and distinct role in sensory processing.journals.physiology.orgAstrocytes and neurons exhibit partially shared but distinct composite receptive fields for natural stimuli | Journal of Neurophysiology | American Physiological SocietyAstrocytes are increasingly recognized as active participants in sensory processing, but whether they show selective responses to stimulus features, analogous to neuronal receptive fields, is not yet ... 060
Reposted by Sihao LuYuriria Vázquez @yurivazu.bsky.social · 23/12/2025Thrilled to share our paper in @pnas.org! "Neural synchrony links sensorimotor cortices in a network for facial motor control" With superb team: Ianni GR (co-first), Rassi E, Rouse AG, Schieber MH, Yazdani F, Prut Y, Freiwald WA. doi.org/10.1073/pnas... 2106
Sihao Lu @sihaolu.bsky.social · 09/12/2025Congrats to Nico for publishing his impressive thesis work! Grateful to have been introduced to this marvellous model system www.cell.com/iscience/ful...cell.comOptogenetic interrogation of the zebrafish lateral line reveals brain-wide neural circuits involved in pattern separationZoology; Neuroscience; Sensory neuroscience 030
Reposted by Sihao LuTim Weber @timweber.bsky.social · 21/11/2025Thankful for this blog piece by @ptrrupprecht.bsky.social on the Dirigo project. Glad you liked the posts! gcamp6f.com/2025/11/14/d...gcamp6f.comDirigo: a future Python alternative to Scanimage?Over the last 20 years, many microscopes that are capable of resonant scanning two-photon microscopy have converged on using ScanImage, a powerful software package with many strengths but also two … 083
Sihao Lu @sihaolu.bsky.social · 07/10/2025Some of the work I did for my PhD finally on biorxiv! We study calcium responses of astrocytes and neurons in vivo in response to ultrasonic vocalisations www.biorxiv.org/content/10.1...biorxiv.orgAstrocytes and neurons encode natural stimuli with partially shared but distinct composite receptive fieldsAstrocytes are increasingly recognized as active participants in sensory processing, but whether they show selective responses to stimulus features, analogous to neuronal receptive fields, is not yet ... 050
Reposted by Sihao LuThe Rockefeller University @rockefeller.edu · 10/09/2025Shortly before his death last month, James Hudspeth and his team achieved a groundbreaking technological advancement: the ability to keep a tiny sliver of the cochlea alive and functional outside of the body for the first time. #RockefellerScience rockefeller.eduResearchers keep a mammalian cochlea alive outside the body for the first time - NewsThe technological breakthrough may improve our understanding of the cellular mechanisms behind hearing loss. 043
Reposted by Sihao LuFrancesco Gianoli @fgiano.bsky.social · 27/08/2025Ants 🐜 coordinate their societies through smell 👃. They carry more odorant receptor genes than any other insect 🧬, yet each olfactory neuron must somehow select and express just one. My brilliant former student Giacomo Glotzer and colleagues have discovered how: www.biorxiv.org/content/10.1...biorxiv.orgTranscriptional Interference Gates Monogenic Odorant Receptor Expression in AntsCommunication is crucial to social life, and in ants, it is mediated primarily through olfaction. Ants have more odorant receptor (OR) genes than any other group of insects, generated through tandem d... 011
Sihao Lu @sihaolu.bsky.social · 18/08/2025It has been a great privilege to have worked with Jim. A truly inspiring individual who embodied a level of kindness, curiosity, and wisdom we should all aspire to. 070
Reposted by Sihao LubioRxiv Neuroscience @biorxiv-neursci.bsky.social · 25/07/2025Axonal defasciculation is restricted to specific branching points during regeneration of the lateral line nerve in zebrafish www.biorxiv.org/content/10.1101/202… 011
Reposted by Sihao LuFrancesco Gianoli @fgiano.bsky.social · 15/07/2025We took the #ear ’s in-built amplifier out of the body, watched it work live, and saw that it runs near a state of #criticality, a knife-edge balance that lets us hear from whispers to thunderclaps and up to 20 kHz. Birds, reptiles, and insects exploit the same physics. #Biophysics shorturl.at/AkMz9shorturl.atAmplification through local critical behavior in the mammalian cochlea | PNASHearing hinges upon the ear’s ability to enhance its responsiveness by means of an energy-expending active process that amplifies the very mechanic... 061
Sihao Lu @sihaolu.bsky.social · 02/07/2025Remember seeing his talk in Kyoto last year, very cool stuff! Congrats! 010
Reposted by Sihao LuPacific Optica @pacificoptica.bsky.social · 25/02/2025youtu.be/9zpWEOJWuD0?... Ventana imaging. The best 2p system. Fast, high rez, 3+ mm field-of-view. pacificoptica.com/ventana/ Turnkey systems, or parts.youtu.beVentana Wide two-photon calcium imagingYouTube video by Pacific Optica 021
Sihao Lu @sihaolu.bsky.social · 08/01/2025Checkout this Journal of Neurophysiology podcast where Andriy, Johnny and John talk about our work generating natural mouse vocalisations using generative adversarial networks: www.podbean.com/ew/pb-xawkr-...podbean.comJNP Micro Podcasts: Bidirectional Generative Adversarial Representation Learning for Natural Stimulus SynthesisIn this episode, coauthors Andriy S. Kozlov, Johnny Reilly, and John D. Goodwin discuss their recently published research titled "Bidirectional Generative Adversarial Representation Learning for Natur... 010
Sihao Lu @sihaolu.bsky.social · 14/11/2024Super proud of both Johnny and John, they demonstrate a generative model for synthesising natural mouse vocalisations and show that these artificially generated vocalisations can be used to probe receptive field properties of neurons in real mice! journals.physiology.org/doi/full/10....journals.physiology.orgBidirectional generative adversarial representation learning for natural stimulus synthesis | Journal of NeurophysiologyThousands of species use vocal signals to communicate with one another. Vocalizations carry rich information, yet characterizing and analyzing these complex, high-dimensional signals is difficult and ... 030
Sihao Lu @sihaolu.bsky.social · 14/11/2024Just repopulating the profile with some old stuff. My first ever paper; showing composite receptive fields in mouse auditory cortex in vivo. Great pleasure working on this as part of my PhD with Andriy Kozlov and others! physoc.onlinelibrary.wiley.com/doi/10.1113/...physoc.onlinelibrary.wiley.comComposite receptive fields in the mouse auditory cortexAbstract figure legend We investigated how auditory cortical neurons in mice represent complex natural stimuli by presenting them with mouse ultrasonic vocalisations (USVs) and pitch-shifted starling... 030