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Sihao Lu

@sihaolu.bsky.social
492 followers 370 following 12 posts

Postdoc @rockefeller.edu with the Hudspeth Lab Astrocytes, auditory processing, two-photon, lightsheet, ephys, machine learning. Previously PhD @imperialcollegeldn.bsky.social Antwerpenaar. sihao.lu

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Sihao Lu @sihaolu.bsky.social · 24/07/2026
Checkout this great work by Jingkun; multiplexed 2-photon voltage imaging. Choose either a huge FOV or multiple depths near-simultaneously!
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Sihao Lu @sihaolu.bsky.social · 06/07/2026
Amazing opportunity to work with an excellent mentor on a great project. Cherry on top: it's in Madrid!
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Reposted by Sihao Lu
Development @dev-journal.bsky.social · 16/02/2026
Axonal defasciculation is restricted to specific branching points during regeneration of the lateral line nerve in zebrafish Read the first #OA article in #DevSIextracellular by Rohan S. Roy and A. J. Hudspeh (@rockefeller.edu) in our Stem Cells and Regeneration section: doi.org/10.1242/dev....
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Sihao Lu @sihaolu.bsky.social · 01/02/2026
Delighted to share this piece of my PhD work: Astrocytes and neurons exhibit partially shared but distinct composite receptive fields for natural stimuli. We show that astrocytes have distinct receptive fields and suggest that they play a complimentary and distinct role in sensory processing.
journals.physiology.org
Astrocytes and neurons exhibit partially shared but distinct composite receptive fields for natural stimuli | Journal of Neurophysiology | American Physiological Society
Astrocytes are increasingly recognized as active participants in sensory processing, but whether they show selective responses to stimulus features, analogous to neuronal receptive fields, is not yet ...
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Reposted by Sihao Lu
Yuriria Vázquez @yurivazu.bsky.social · 23/12/2025
Thrilled to share our paper in @pnas.org! "Neural synchrony links sensorimotor cortices in a network for facial motor control" With superb team: Ianni GR (co-first), Rassi E, Rouse AG, Schieber MH, Yazdani F, Prut Y, Freiwald WA. doi.org/10.1073/pnas...
Title and authors of our PNAS paper on neural synchrony and facial motor control
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Sihao Lu @sihaolu.bsky.social · 09/12/2025
Congrats to Nico for publishing his impressive thesis work! Grateful to have been introduced to this marvellous model system www.cell.com/iscience/ful...
cell.com
Optogenetic interrogation of the zebrafish lateral line reveals brain-wide neural circuits involved in pattern separation
Zoology; Neuroscience; Sensory neuroscience
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Reposted by Sihao Lu
Tim Weber @timweber.bsky.social · 21/11/2025
Thankful for this blog piece by @ptrrupprecht.bsky.social on the Dirigo project. Glad you liked the posts! gcamp6f.com/2025/11/14/d...
gcamp6f.com
Dirigo: a future Python alternative to Scanimage?
Over the last 20 years, many microscopes that are capable of resonant scanning two-photon microscopy have converged on using ScanImage, a powerful software package with many strengths but also two …
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Sihao Lu @sihaolu.bsky.social · 07/10/2025
Some of the work I did for my PhD finally on biorxiv! We study calcium responses of astrocytes and neurons in vivo in response to ultrasonic vocalisations www.biorxiv.org/content/10.1...
biorxiv.org
Astrocytes and neurons encode natural stimuli with partially shared but distinct composite receptive fields
Astrocytes are increasingly recognized as active participants in sensory processing, but whether they show selective responses to stimulus features, analogous to neuronal receptive fields, is not yet ...
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Reposted by Sihao Lu
The Rockefeller University @rockefeller.edu · 10/09/2025
Shortly before his death last month, James Hudspeth and his team achieved a groundbreaking technological advancement: the ability to keep a tiny sliver of the cochlea alive and functional outside of the body for the first time. #RockefellerScience
rockefeller.edu
Researchers keep a mammalian cochlea alive outside the body for the first time - News
The technological breakthrough may improve our understanding of the cellular mechanisms behind hearing loss.
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Reposted by Sihao Lu
Francesco Gianoli @fgiano.bsky.social · 27/08/2025
Ants 🐜 coordinate their societies through smell 👃. They carry more odorant receptor genes than any other insect 🧬, yet each olfactory neuron must somehow select and express just one. My brilliant former student Giacomo Glotzer and colleagues have discovered how: www.biorxiv.org/content/10.1...
biorxiv.org
Transcriptional Interference Gates Monogenic Odorant Receptor Expression in Ants
Communication is crucial to social life, and in ants, it is mediated primarily through olfaction. Ants have more odorant receptor (OR) genes than any other group of insects, generated through tandem d...
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Sihao Lu @sihaolu.bsky.social · 18/08/2025
It has been a great privilege to have worked with Jim. A truly inspiring individual who embodied a level of kindness, curiosity, and wisdom we should all aspire to.
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Reposted by Sihao Lu
bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 25/07/2025
Axonal defasciculation is restricted to specific branching points during regeneration of the lateral line nerve in zebrafish www.biorxiv.org/content/10.1101/202…
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Reposted by Sihao Lu
Francesco Gianoli @fgiano.bsky.social · 15/07/2025
We took the #ear ’s in-built amplifier out of the body, watched it work live, and saw that it runs near a state of #criticality, a knife-edge balance that lets us hear from whispers to thunderclaps and up to 20 kHz. Birds, reptiles, and insects exploit the same physics. #Biophysics shorturl.at/AkMz9
shorturl.at
Amplification through local critical behavior in the mammalian cochlea | PNAS
Hearing hinges upon the ear’s ability to enhance its responsiveness by means of an energy-expending active process that amplifies the very mechanic...
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Reposted by Sihao Lu
Pacific Optica @pacificoptica.bsky.social · 25/02/2025
youtu.be/9zpWEOJWuD0?... Ventana imaging. The best 2p system. Fast, high rez, 3+ mm field-of-view. pacificoptica.com/ventana/ Turnkey systems, or parts.
youtu.be
Ventana Wide two-photon calcium imaging
YouTube video by Pacific Optica
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Sihao Lu @sihaolu.bsky.social · 09/02/2025
Had a great time working with Nico on this!
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Sihao Lu @sihaolu.bsky.social · 08/01/2025
Checkout this Journal of Neurophysiology podcast where Andriy, Johnny and John talk about our work generating natural mouse vocalisations using generative adversarial networks: www.podbean.com/ew/pb-xawkr-...
podbean.com
JNP Micro Podcasts: Bidirectional Generative Adversarial Representation Learning for Natural Stimulus Synthesis
In this episode, coauthors Andriy S. Kozlov, Johnny Reilly, and John D. Goodwin discuss their recently published research titled "Bidirectional Generative Adversarial Representation Learning for Natur...
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Sihao Lu @sihaolu.bsky.social · 14/11/2024
Super proud of both Johnny and John, they demonstrate a generative model for synthesising natural mouse vocalisations and show that these artificially generated vocalisations can be used to probe receptive field properties of neurons in real mice! journals.physiology.org/doi/full/10....
journals.physiology.org
Bidirectional generative adversarial representation learning for natural stimulus synthesis | Journal of Neurophysiology
Thousands of species use vocal signals to communicate with one another. Vocalizations carry rich information, yet characterizing and analyzing these complex, high-dimensional signals is difficult and ...
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Sihao Lu @sihaolu.bsky.social · 14/11/2024
Just repopulating the profile with some old stuff. My first ever paper; showing composite receptive fields in mouse auditory cortex in vivo. Great pleasure working on this as part of my PhD with Andriy Kozlov and others! physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com
Composite receptive fields in the mouse auditory cortex
Abstract figure legend We investigated how auditory cortical neurons in mice represent complex natural stimuli by presenting them with mouse ultrasonic vocalisations (USVs) and pitch-shifted starling...
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