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Pacific Optica

@pacificoptica.bsky.social
305 followers 978 following 79 posts

Optics for multiphoton imaging, laser scanning, and more. Based in Santa Barbara, California. pacificoptica.com

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Reposted by Pacific Optica
Ewa Zarnowska @ewadorotaz.bsky.social · 11/08/2026
I hope you’ll have a chance one day to see the images captured with Ventana. Also offered with its holographic optogenetics option and supported with Monaco laser. Ventana truly offers a window into the brain at scale! And the brilliant people behind it are another reason why it is so special. 🚀🧠🥳🤓
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Pacific Optica @pacificoptica.bsky.social · 11/08/2026
At the CSHL course Imaging Structure & Function in the Nervous System, there was a Ventana system. It has a >9 mm^2 field-of-view with high resolution and so people are surprised that it’s so small! Here’s a size reference (12 oz can) for a sense of scale. More compact than most other 2-photon rigs.
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Pacific Optica @pacificoptica.bsky.social · 27/07/2026
Check out this compact 920 nm ultrafast fs laser for 2p imaging of GCaMP, etc.. Mounted on its side like this, it takes up very little space on the table. That's the Axon 920, generously loaned to the course thanks to @ewadorotaz.bsky.social and others at Coherent. It's what we use on our own rigs.
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Pacific Optica @pacificoptica.bsky.social · 27/07/2026
Che-Hang brought the Ventana, and @ianoldenburg.bsky.social brought the holography. All-optical 2p neurophysiology @cshlcourses.bsky.social A great collab. Summer courses are the best.
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Pacific Optica @pacificoptica.bsky.social · 25/07/2026
On Instagram now too... www.instagram.com/pacificoptica/ And LinkedIn... www.linkedin.com/posts/pacifi... Let's keep in touch.
A screenshot of the Pacific Optica Instagram account, with a photo of the Cousa multiphoton objective 10x/0.5NA 20 mm working distance in air. 2p and 3p. 2-3 mm wide field-of-view.
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Pacific Optica @pacificoptica.bsky.social · 25/07/2026
The turnkey Ventana Wide 2-photon imaging system is in service at the CSHL Imaging course. Dr. Che-Hang Yu is happy to share its capabilities. @cshlcourses.bsky.social
A Ventana Wide two-photon imaging system in the foreground. This is a completely turnkey imaging system optimized for multiphoton imaging in vivo, for neuroscience applications and beyond. Dr. Che-Hang Yu is standing in the background.
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Pacific Optica @pacificoptica.bsky.social · 23/06/2026
Imaging fish at MBL. Field-of-view is 2 mm x 1 mm. 2048 x 1024 pixels. (submicron pixels) with the Ventana system -- the fastest imaging systems over large fields of view. pacificoptica.com/ventana/
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Pacific Optica @pacificoptica.bsky.social · 18/06/2026
We're at the MBL in Woods Hole, MA. Stop on by if you want to try it out for yourself. 2-photon imaging over a 3 mm x 3 mm field-of-view. The most compact mesoscale 2p also has the fastest scanning! pacificoptica.com/ventana/ pacificoptica.com/cousa/
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Pacific Optica @pacificoptica.bsky.social · 22/05/2026
FN > 45 Whatever objective you use, Ventana imaging systems will get more field-of-view out of it, with full NA, and diffraction limited. The best ever for multiphoton / two-photon. And fast! 16,000 - 24,000 lines/s across the full field of view. pacificoptica.com/ventana/
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Pacific Optica @pacificoptica.bsky.social · 08/05/2026
Cool paper from Garret Stuber's lab and colleagues, led by Madelyn Hjort. mPFC-VTA circuit for contingency degredation. doi.org/10.1038/s415... Fig. 3 & 4 used the Cousa objective: **2p imaging + 2p holographic optogenetic stim., deep in brain using microprisms** ! pacificoptica.com/cousa/
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Pacific Optica @pacificoptica.bsky.social · 12/04/2026
All Pacific Optica products are designed in Santa Barbara, California, USA.
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Pacific Optica @pacificoptica.bsky.social · 09/04/2026
Laser scanning on your equipment entails tradeoffs between speed, resolution, and field-of-view. Pick 2 of those 3. Now you can get all 3, with this breakthrough. www.laserfocusworld.com/optics/artic... Thanks @laserfocusworld.bsky.social
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Pacific Optica @pacificoptica.bsky.social · 20/03/2026
Huge field-of-view, fast, high res. two-photon imaging. This technology (paper link below) is available now, in the Ventana products. Sold as complete turnkey systems, or components. pacificoptica.com/ventana/ Installations are happening now at some of the best labs in the world.
A CAD rendering of a Ventana two-photon imaging system.
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Pacific Optica @pacificoptica.bsky.social · 20/03/2026
An excited customer, sharing photos of the optics they just received. And one of the first Avocado objectives in customer hands. It's a Cousa-class objective, with an NA of 0.6 and a WD of 10 mm, optimized for 2p, and excellent performance out to the edges of the field-of-view. More info soon!
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Pacific Optica @pacificoptica.bsky.social · 19/03/2026
Loving the "CEO eats his own burger/hot dog/..." stuff. Pacific Optica's CEO uses his own Ventana, Diesel2p, and Cousa products. They're the high throughput, turnkey, workhorse systems that power the lab. pacificoptica.com/ventana/ pacificoptica.com/diesel2p/ pacificoptica.com/cousa/
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Pacific Optica @pacificoptica.bsky.social · 02/01/2026
“Because [science] is the most effective way of learning about the physical world, it erodes superstition, ignorance and prejudice, which have been at the root of the denial of human rights throughout history…” -Baron Taverne
Photo of Eccles. “Because [science] is the most effective way of learning about the physical world, it erodes superstition, ignorance and prejudice, which have been at the root of the denial of human rights throughout history…” -Baron Taverne
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Pacific Optica @pacificoptica.bsky.social · 02/01/2026
“Because scientific knowledge is tentative and provisional, it is the enemy of dogma.” -Baron Taverne
Photo of Rita Levi-Montalcini. "Because scientific knowledge is tentative and provisional, it is the enemy of dogma.” -Baron Taverne
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Pacific Optica @pacificoptica.bsky.social · 02/01/2026
“Because science rejects claims to truth based on authority and depends on the criticism of established ideas, it is the enemy of autocracy.” -Baron Taverne
Photo of Cajal. “Because science rejects claims to truth based on authority and depends on the criticism of established ideas, it is the enemy of autocracy.” -Baron Taverne
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Pacific Optica @pacificoptica.bsky.social · 01/01/2026
In 2025, we unlocked new frontiers in multiphoton optics and imaging. In 2026, you can get the best 2p systems you’ve ever seen. Accelerating your work. Higher throughput. Easy to use. Focus on your neuro work, and leave the 2p to PacOp.
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Pacific Optica @pacificoptica.bsky.social · 31/10/2025
Happy Halloween! pacificoptica.com/cousa/
A person dressed up as a Cousa objective.
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Pacific Optica @pacificoptica.bsky.social · 20/08/2025
Check out some sweet Ventana Wide + Cousa imaging. pacificoptica.com/ventana/ Live raw data over a 3.2 mm wide field-of-view with 16,000 lines/s scanning and submicron resolution. Demo now at @omibs-mbl.bsky.social Thx @ewadorotaz.bsky.social @mbfbioscience.bsky.social @crisrodtsou.bsky.social !
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Reposted by Pacific Optica
OMIBS @ MBL @omibs-mbl.bsky.social · 19/08/2025
@pacificoptica.bsky.social @leicamicrosystems.bsky.social @thorlabs.bsky.social
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Pacific Optica @pacificoptica.bsky.social · 14/08/2025
Scientists explore, measure, gather evidence, figure things out, and share openly. Their work benefits us all. Demo imaging at MBL/Woods Hole and CSHL this summer. Explore further. pacificoptica.com
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Pacific Optica @pacificoptica.bsky.social · 02/08/2025
Put whatever objective you want on the Ventana Wide. It will give you the largest field of view with high speed scanning: eg, 3.2mm x 3.2mm with a 10x. Fast, flexible 2p imaging. Che-Hang Yu is helping MBL courses with this Ventana Wide system pacificoptica.com/ventana/
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Pacific Optica @pacificoptica.bsky.social · 02/08/2025
Just landed in Woods Hole for summer courses: a Full Ventana Wide system. pacificoptica.com/ventana/ with a Cousa pacificoptica.com/cousa/ www.mbl.edu/education/ad... www.mbl.edu/education/ad... Thanks, Coherent! Thanks, MBF! Thanks to course leadership and MBL staff!
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Pacific Optica @pacificoptica.bsky.social · 30/07/2025
Widespread cortical representations of innate behaviors in the mouse. www.biorxiv.org/content/10.1... Using the Diesel2p pacificoptica.com/diesel2p/, they found that "more directed and unilateral grooming movements had greater cortical associated responses than more stereotyped bilateral movements"
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Pacific Optica @pacificoptica.bsky.social · 19/07/2025
We will start gathering at about 3:00.
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Pacific Optica @pacificoptica.bsky.social · 18/07/2025
吉祥寺 日曜日。2-photon, optics, 生ビルと TexMex 食べ物。 maps.app.goo.gl/xoRrGNX7xvK1... ふるってご参加ください。
maps.app.goo.gl
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Pacific Optica @pacificoptica.bsky.social · 14/07/2025
No more stitching artifacts. Just image the whole field-of-view, at high resolution, in one pass. The Ventana systems give submicron resolution over huge fields-of-view almost 10 square mm. At high speed. Cover a 3.2 mm x 3.2 mm area in 4k resolution in 0.26 s. pacificoptica.com/ventana/
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Pacific Optica @pacificoptica.bsky.social · 13/07/2025
Explore further. pacificoptica.com/diesel2p/
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Pacific Optica @pacificoptica.bsky.social · 12/07/2025
Cool!! This is an exciting new Neuro AI #NeurIPS competition. By the way, the large scale 2p data for this NeurIPS competition was taken with a Diesel2p system. pacificoptica.com/diesel2p/
pacificoptica.com
Diesel2p - Pacific Optica
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Reposted by Pacific Optica
SPIE @spie.org · 09/07/2025
🌌 Curious how visionary engineering shaped one of humanity’s greatest scientific instruments? Discover the architectural origins of the JWST in this in-depth #SPIE_JATIS article: www.spiedigitallibra...
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Reposted by Pacific Optica
Pacific Optica @pacificoptica.bsky.social · 17/06/2025
ALERT: New journal club style! S. L. Smith listens to and provides commentary on an AI-generated fake podcast on their new preprint. Hilarious in parts, and fun and chill. Everyone: Please do this for your papers too! m.youtube.com/watch?v=qO1n...
m.youtube.com
Non-inertial scan angle multiplier - AI-generated podcast with actual human commentary
YouTube video by Spencer LaVere Smith
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Reposted by Pacific Optica
Michelle Itano @michelleitano.bsky.social · 24/06/2025
So excited to hang the ‘Acknowlegement Guidelines’ poster up in Chapel Hill! Grateful to be part of the community working towards equitable recognition for imaging scientists!! Read more and download the poster (in 10 languages!): lnkd.in/eSQRugJX #CreditWhereItsDue #AcknowledgementGuidelines
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Pacific Optica @pacificoptica.bsky.social · 24/06/2025
Now published in Plos Biology journals.plos.org/plosbiology/...
journals.plos.org
Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures
Ovarian multinucleated giant cells are a unique macrophage population that arise within the aging mammalian ovary. This study characterizes their transcriptome in mice, uncovering a potential role in ...
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Pacific Optica @pacificoptica.bsky.social · 23/06/2025
Animals sense in complex environments, and neuronal responses to olfactory/scent stimuli can be shaped by recent history going back ~ 30 s. Here, Subramanian, Storace, et al. used the Cousa objective pacificoptica.com/cousa/ to neural activity in vivo. doi.org/10.1093/chem... #microscopymonday
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Pacific Optica @pacificoptica.bsky.social · 23/06/2025
Multinucleated giant cells (MNGCs) emerge as ovaries age, and are hard to study. Here, Converse, Pritchard, Duncan et al. used 2p imaging with the Cousa objective pacificoptica.com/cousa/ in their comprehensive study of age-associated MNGCs. #microscopymonday www.biorxiv.org/content/10.1...
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Pacific Optica @pacificoptica.bsky.social · 23/06/2025
This system has tons of fascinating tech— optics, detectors, software— so many scientists and engineers collaborated on this international project, enjoy the fruits of their talents!
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Reposted by Pacific Optica
Bruno Pichler @brunopichler.bsky.social · 19/06/2025
Fantastic work (as always) from Che-Hang Yu and colleagues in Spencer LaVere Smith's lab. Very neat method to increase scan speed and/or FOV in 2p microscopy. Commercially available from @pacificoptica.bsky.social. I'd love to build this for a client at some point! www.biorxiv.org/content/10.1...
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Reposted by Pacific Optica
NSF–DOE Rubin Observatory @rubinobservatory.org · 17/06/2025
🚨THIS IS NOT A DRILL🚨We are 6 days away from the world's First Look at images from Rubin! #RubinFirstLook 🔭🧪 NSF–DOE Rubin Observatory will take a new 3200-megapixel image every ~40s, yielding ~20 terabytes of data every night! The deluge of data is about to begin 🌊
Rubin Observatory's car-sized digital camera mounted on the telescope. Seen at an angle face-on, the camera is a long black tube cutting vertically through the top two-thirds of the image. Its giant clear glass lens is visible toward the top. To the left and right of the camera, scaffolding for staff access is set up. The background is an array of black and teal steel, both part of the telescope and beyond as part of the dome.
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Pacific Optica @pacificoptica.bsky.social · 17/06/2025
ALERT: New journal club style! S. L. Smith listens to and provides commentary on an AI-generated fake podcast on their new preprint. Hilarious in parts, and fun and chill. Everyone: Please do this for your papers too! m.youtube.com/watch?v=qO1n...
m.youtube.com
Non-inertial scan angle multiplier - AI-generated podcast with actual human commentary
YouTube video by Spencer LaVere Smith
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Pacific Optica @pacificoptica.bsky.social · 16/06/2025
Riddle: When is an "optical invariant" is not so invariant? How can you get a larger field-of-view for free? No change in resolution or scan speed. No more stitching needed! For #MicroscopyMonday here's a new preprint to check out. 1/9
A two-photon view of the living brain in action. Single snapshot. Large field-of-view.
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Pacific Optica @pacificoptica.bsky.social · 29/05/2025
Scientists at work. This is a #ucsantabarbara collab with www.mbfbioscience.com Diesel2p pacificoptica.com/diesel2p/
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Pacific Optica @pacificoptica.bsky.social · 27/04/2025
Upgrade your 2p to 4k. We used to have to trade off resolution to get a larger field-of-view. Now, with Ventana, you don’t have to. Keep your resolution. Keep your frame rate. And get 4x the field-of-view. pacificoptica.com/ventana/
pacificoptica.com
Ventana - Pacific Optica
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Pacific Optica @pacificoptica.bsky.social · 23/04/2025
What’s new, etendue? Spencer LaVere Smith will be presenting new optics at the @optica.org conference in San Diego tomorrow.
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Rita Strack @ritastrack.bsky.social · 10/04/2025
Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.
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Pacific Optica @pacificoptica.bsky.social · 06/04/2025
Multiphoton imaging products from Pacific Optica are now easier to get in Japan. すごい!https://www.symphotony.com/manufacturers/pacificoptica/
symphotony.com
Pacific Optica | 光響
光響は Pacific Optica (パシフィックオプティカ)の製品を取り扱っています。 Pacific Optica は対物レンズ、スキャンレンズ、チューブレンズ、スキャンエンジン、そして神経科学、生体工学、臨床検査、生物学研究、先端製造の新しい探求を可能にする関連技術を開発しています。
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Pacific Optica @pacificoptica.bsky.social · 25/02/2025
youtu.be/9zpWEOJWuD0?... Ventana imaging. The best 2p system. Fast, high rez, 3+ mm field-of-view. pacificoptica.com/ventana/ Turnkey systems, or parts.
youtu.be
Ventana Wide two-photon calcium imaging
YouTube video by Pacific Optica
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Reposted by Pacific Optica
Benjamin Judkewitz @benjulab.bsky.social · 03/11/2024
We’re seeking a postdoc/student excited about animal communication, brain-wide circuits, microscopy, singing fish (Danionella), wacky ideas and who likes to: get things done, experiment, analyze, ask, learn, help and cooperate. jlab.berlin
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Pacific Optica @pacificoptica.bsky.social · 26/01/2025
Brand new online today. The biggest fields-of-view scanned fast, for multiphoton imaging. pacificoptica.com/ventana/
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