iiinova — where your digital self keeps evolving

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 04/10/2026

I've just posted my thoughts on today's programme over on LinkedIn. I'm still struggling with which platform to socials should be on LinkedIn doesn't feel live. Here feels lonely compared to the old (pre-toxic) days of Twitter

120

Reposted by ShinyBlackShoe (Calum Polwart)

Gwen C. Katz @gwenckatz.bsky.social · 09/02/2026

Great chance to post my all-time favorite headline

The Radium Water Worked Fine Until His Jaw Came Off

2033701258

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 03/10/2026

I wish we could rename MDTs. Are we referring to Multi Disciplinary Team Meetings or Multi Disciplinary Working? #BOPA2026

000

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 03/10/2026

Rob Duncombe sharing all his years of knowledge in 3 ways to get a business case approved: - improve safety - improve patient experience - balance the books Just because the hospital down the road does it doesn't mean you'll get a case approved #BOPA2026

010

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 03/10/2026

#BOPA2026 Pharmacokinetics modelling - My reservation with saying dose banding sits above BSA in the hierarchy is that this depends on the width of the bands. If you band small-medium-large then yes that's in that hierarchy. If you are using the ± 6% variance we use... It's the same level

100

Reposted by ShinyBlackShoe (Calum Polwart)

Brian @brianmackenna.bsky.social · 03/10/2026

Imo they should focus on making the data available as this would reduce reliance on one organisation having staff available My 5k words on it pubmed.ncbi.nlm.nih.gov/35634533/

pubmed.ncbi.nlm.nih.gov

Checking your browser - reCAPTCHA

011

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 03/10/2026

#BOPA2026 Are you wanting to track your SC switch progress against your peers? 👇🏻👇🏻👇🏻

022

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 03/10/2026

#BOPA2026 ORAL ABSTRACT SESSION This is always my highlight of BOPA seeing what colleagues have been working on, and hopefully seeing the best of the work submitted. Here is a 🧵👇🏻👇🏻

111

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 03/10/2026

Just wrote a thread of the first 3 #BOPA2026 Oral Abstract presentations. Phone switched its self off and on. I will catch up. But just to say so far -- the quality of slides and 🗣️ has been bang on.

020

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 03/10/2026

@brianmackenna.bsky.social thought you'd want to see this. James Richardson presenting . This was based on data from July and I think was self reported. #BOPA2026

110

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 02/10/2026

As with my #AI 🧵from #BOPA2026 there is a Real World Outcomes #RWO/#RWE theme running through some posters. I notice people don't know where to put these - are they audit (but against what standard?), are they research (but are the results generalisable?) or should they have their own category?

110

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 02/10/2026

The #BOPA2026 posters are not short of #AI studies. Now we can argue for or against the use of #ArtificialIntelligence in these settings but there are some eye catching time savings for the use of these #LLM's so it's no surprise people are keen to see what they can deliver.

tripod-llm.vercel.app

Tripod + LLM

A checklist for LLM research development.

010

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 02/10/2026

Now I'm normally no fan of early access schemes. But if one was ever needed (preferably an EAMS or does Project Or is still exist?) it would be for daraxonrasib in pancreatic Do we know why not? Would #BOPA2026 want it?

Survival curve from daraxonrasib from RASolute302

011

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 02/10/2026

Some initial thoughts on posters from #BOPA2026. 1️⃣ The visuals on some of the posters have absolutely moved on from 10 years ago. I assume AI (LLM's) are part of that. But excellent to see some high quality postering and less of the 3D Excel Chart copied into a word document and stretched

120

Reposted by ShinyBlackShoe (Calum Polwart)

Chloe Waterson @chloewaterson.bsky.social · 02/10/2026

Presenting my work on real-world outcomes for patients with mHSPC treated with enzalutamide at #BOPA2026 this year. If you've ever had doubts about the effect on outcomes of dose reducing, hopefully this will help to reassure! Patients on dose reductions did at least as well as those without.

143

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 02/10/2026

Connor says what about template letters We use template letters. How do we check the letter contains what Connor needs ? @hflint.bsky.social #BoPA2026

010

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 02/10/2026

Friday evening at #BOPA2026 is poster night. This year is another record breaking year for posters. I'll be sharing some thoughts on that later. But for now - here is my poster. doi.org/10.6084/m9.f...

231

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 02/10/2026

Excellent question from Helen about EPS of medicines from secondary care. But - 1. We need that to work for low risk SACT (cdk46 etc) 2. We need chief pharmacist to not freek out about the costs EPS needs to be in SACT prescribing systems folks!! #BOPA2026

A question about EPS to primary care from secondary care

111

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 02/10/2026

As the NHS enters yet another restructure, are we about to lose a bunch of national work because NHSE won't exist. So we will end up with local projects that never scale up. There is no plan #BOPA2026

010

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 02/10/2026

Frustrated that perhaps 23 years ago, I could have heard almost the same words from the top. Perhaps less so the community pharmacy but everything else were the same words I'm already worried about capacity for oral SACT dispensing while everyone is still stuck on aseptics #BOPA2026

011

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 02/10/2026

Should research be done on weekends? My view has always been that research is enjoyable. That's why it's the bit I might leave to a weekend. #BOPA2026 But am I wrong to think being a pharmacist might not be a 37.5h job? It's a career

210

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 02/10/2026

#BOPA2026 Dare I ask if there is protected funding in secondary care. Should the Q have been sector agnostic? Most of us were disappointed that the Cancer plan didn't recognise the increased pressure caused by the numerous new approvals. There is no measure of delivery of any of this.

Question asking how protected cancer funding can be secured in primary care

031

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 02/10/2026

A different layout of conference room from usual. Thinner but much longer room. I think busier than usual for a 10:20am start too - #BOPA2026 @bopa.org.uk Now folks... You know the rules. If you don't want me at the microphone for questions you better ask some yourselves

111

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 02/10/2026

If we want to find the future murders and intervene .. I wonder if we should observe hotel breakfast areas. The crimes to humanity here must be a 🚩 Don't put golden syrup on a crumpet folks. 👩🏻‍⚖️👮🏻‍♀️🔒

000

Reposted by ShinyBlackShoe (Calum Polwart)

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 17/11/2024

If you post about Oncology Pharmacy #OncoPharm here is a Starter Pack. If you want added to it let me know. #PharmSky Good luck. Hope this side of the fence is nicer. 🤞🏻 go.bsky.app/USU71ai

Starter pack image for OncoPharm accounts on BlueSky.

Links to:
https://go.bsky.app/USU71ai

355

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 01/10/2026

I'm going to post here this year. But I don't know if I'm talking to myself these days. So please do interact (likes, reposts etc) if you find posts helpful or even feel free to argue if you think I'm wrong. If there's no love here this weekend I'm probably not posting in 2027. #BOPA2026 #oncopharm

030

Reposted by ShinyBlackShoe (Calum Polwart)

The Pharmaceutical Journal @pharmaj.bsky.social · 30/09/2026

In this news analysis piece, we highlight that coroners have warned public bodies six times in three years about the threat medicine shortages pose to patients and examine what pharmacists and patient groups say must change #ukpharmacy #medicinesshortages buff.ly/Ufw3Vfe

buff.ly

The lives cut short by medicine shortages

With pharmaceutical companies sending an average of four medicine shortage warnings to the government each day, the issue of drug supply has a tight grip over the NHS and its patients. June 2026 saw…

001

Reposted by ShinyBlackShoe (Calum Polwart)

The Pharmaceutical Journal @pharmaj.bsky.social · 30/09/2026

This learning article, which is part of a comprehensive series showing how to evaluate a clinical study or research paper, explains when different statistical tests should be used to interpret trial data #ukpharmacy #researchdesign #clinicalstudies buff.ly/eEiVVHM

001

Reposted by ShinyBlackShoe (Calum Polwart)

The Pharmaceutical Journal @pharmaj.bsky.social · 30/09/2026

This learning article, which is part of a comprehensive series showing how to evaluate a clinical study or research paper, shows how to analyse the association between variables in clinical trial data #ukpharmacy #researchdesign #clinicalstudies buff.ly/nZ5wiAj

buff.ly

Understanding correlation, regression and survival analysis

This article is part of a comprehensive series exploring how to evaluate clinical studies when addressing information needs using a five-step process: This article explores the fifth step:…

001

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 01/10/2026

It's October, which means it's time for #BOPA2026 the annual @bopa.org.uk symposium. If you don't follow me for #OncoPharm stuff - find the mute button. I will be posting some thoughts on BlueSky and some content to LinkedIn too.

000

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 28/08/2026

jamanetwork.com/journals/jam... The US and it's use of biosimilars blows my mind all the time. Why would the insurance companies not insist on it? The rates of switch are tiny. And why are the savings not more? Interestingly the 🏴󠁧󠁢󠁥󠁮󠁧󠁿 data which is openly accessible does not identify biosim

jamanetwork.com

Cancer Biologics Utilization After Biosimilar Entry and Financial Implications For Payers and Patients

This cohort study assesses market dynamics and examine financial implications associated with biosimilar use patterns among patients who received bevacizumab, rituximab, or trastuzumab.

001

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 19/08/2026

Having a reflective evening as I mull over a conference abstract rejection. Did the abstract hit the wrong note? Did it not tell an interesting story? Did I somehow get the message wrong? Should I care? I've had plenty journal submissions desk rejected in minutes. Never a poster abstract...

100

Reposted by ShinyBlackShoe (Calum Polwart)

The Economist @economist.com · 18/08/2026

In a recent study, pupils using AI saw their average homework score rise by 18% across all subjects after six months. But come exam time, the same students scored 20% below their classmates who had not called on AI’s help. We analyse the data

bit.ly

Does AI stop children from learning?

New data show the peril and promise of the technology

68254

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 17/08/2026

journals.sagepub.com/doi/full/10.... Articles like this provide useful insight to the real world. I suspect the UK (sorry 🏴󠁧󠁢󠁥󠁮󠁧󠁿) has even more data on switching. We lack some outcome info. I bet clinicians wouldn't mind providing that if it was for use...

journals.sagepub.com

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

100

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 10/08/2026

Probably 18 months ago - maybe more - the fabulous team at #OpenPrescribing shared their beta of Open Hospital Prescribing one of the first things I did was take a look at CDK4/6i use to see if there was a noticeable shift in use - post OS data being published. Since then - we've been working on 👇🏻

101

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 07/08/2026

Anyone would think that dropping the FMD to claim a Brexit win had been a stupid idea. But you'd also think that if barcodes really made a difference to workflow, then market forces would push it to happen? Take a look at Aldi and Lidl packaging...

000

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 31/07/2026

I've written to 'Thr Oncologist' because I think it's really important we try to keep the record clear - if there is an interaction with PPIs and palbociclib, the only evidence if for the old capsule formulation. doi.org/10.1093/onco... If we get generics and they are capsules that could matter.

doi.org

Proton-Pump Inhibitor use in combination with a CDK4/6 inhibitor: Is formulation the issue?

Calum Polwart; Proton-Pump Inhibitor use in combination with a CDK4/6 inhibitor: Is formulation the issue?, The Oncologist, , oyag293, https://doi.org/10.1

100

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 04/07/2026

Oh interesting 10.1001/jamaoncol.2026.2191 ct-DNA in resected liver mets. OK it's retrospective analysis. But as you might hope, ctDNA at resection is a bad sign. Negativity is a good sign But there is an additional hidden info...

110

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 30/06/2026

www.bbc.co.uk/news/article... My mind is blown. It feels like a sketch from Yes Minister! "Repay the generosity of the British people". You'd almost think that was the concept of taxation. That as those people earn they pay it forward? And as for this sentence 👇🏻

bbc.co.uk

Refugees will be told to repay £10,000 under new asylum rules

Ministers will be given powers to recover costs from adults who have received asylum support under new laws.

110

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 26/06/2026

The NYT says "it was too good to be true". They are right. Biologically it seemed implausible. A drug with a massive half life. With randomisation only apply to the first few doses. And now a load of research integrity questions. www.nature.com/articles/s41...

nature.com

Retraction Note: Time-of-day immunochemotherapy in non-small cell lung cancer: a randomized phase 3 trial - Nature Medicine

Nature Medicine - Retraction Note: Time-of-day immunochemotherapy in non-small cell lung cancer: a randomized phase 3 trial

134

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 27/03/2026

I never quite understand why in this country when this happens... People just carry on... But in the US this would result in a full shutdown. That said. I don't understand why a contract can't be ready.

000

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 03/03/2026

Cancer patients ditch NHS for private chemotherapy share.google/fKKhDJVQqyrf... 12% ⬆️ from 2021 to now. So if I did my maths right.. is less than a 2.9% annual increase in activity. While the NHS thinks chemo activity increases 6-8% annually. In other words.. private sector under delivering

share.google

111

ShinyBlackShoe (Calum Polwart) @shinyblackshoe.bsky.social · 13/02/2026

Feels nuts that this is even a standard! Time critical... 24 hours...

021

Reposted by ShinyBlackShoe (Calum Polwart)

Royal College of Pharmacy @rc-pharm.bsky.social · 30/01/2026

New to #RPSLibrary: Neonatal Formulary: Drug Use in Pregnancy and the First Year of Life – 9th ed. (2026) Read it here: ow.ly/5Bmj50Y62pR under ‘Pediatrics'

001