iiinova — where your digital self keeps evolving

Dave Shechner @shechnerlab.bsky.social · 02/09/2026

📄 Our latest review is now out in Current Opinion in Chemical Biology! We discuss a growing class of oligonucleotide-directed proximity labeling strategies that use programmable DNA hybridization to target RNAs and genomic loci. This was a fun one to write—I hope you enjoy it! bit.ly/4h6KaRV

bit.ly

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Dave Shechner @shechnerlab.bsky.social · 05/08/2026

🔥PREPRINT ALERT🔥 We often think of mitochondria as one interconnected network. But are all mitos the same? Our new preprint-a fantastic collaboration with @yasesancak.bsky.social -reveals that organelle contacts establish specialized mitochondrial populations. Check out Yasemin’s awesome thread 👇

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Dave Shechner @shechnerlab.bsky.social · 20/09/2025

AWESOME CONFERENCE ALERT!! I had an absolute blast at the Fusion “Genome Regulation Through RNA” meeting back in 2024, and psyched to see its upcoming return! Let’s geek out about all things Chromatin and RNA together, in Cancun! Talk abstract deadline: 10/17 Details👇

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Dave Shechner @shechnerlab.bsky.social · 07/08/2025

Holy moly, that’s awesome!! Congrats, Rita!!

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Dave Shechner @shechnerlab.bsky.social · 02/08/2025

I’m a bit late to the game here, but wanted to highlight this very clever technique from @paraspeckle.bsky.social’s group! Congrats to all authors!!

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Dave Shechner @shechnerlab.bsky.social · 01/07/2025

Aw man, the pleasure was all mine!! 🙏🙏🙏

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Dave Shechner @shechnerlab.bsky.social · 30/06/2025

Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit! tinyurl.com/ydn6e3ac

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Dave Shechner @shechnerlab.bsky.social · 10/04/2025

They will take over the middle parts of our feeds, surely.

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Dave Shechner @shechnerlab.bsky.social · 10/04/2025

Invariably there’s a moment in all of my trainees’ careers where I have to explain the difference between hyphens, en-dashes, and em-dashes, and they look at me like, “what happened to you?!” And I just kinda’ stare off to space and wonder the same thing…

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Dave Shechner @shechnerlab.bsky.social · 15/03/2025

Ridiculous. There’s no fourth month…

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Dave Shechner @shechnerlab.bsky.social · 14/03/2025

FUN FACT: In Europe, they celebrate #PiDay on the 3rd day of the 14th month.

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Dave Shechner @shechnerlab.bsky.social · 22/01/2025

But that pentavalent carbon though…

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Dave Shechner @shechnerlab.bsky.social · 31/12/2024

TOP FIVE METABOLIC PATHWAYS …Based on whether they sound like the name of an old-school anime: 5. The Pentose-Phosphate Shunt 4. Peptidoglycan Degradation 3. Fatty Acid Beta-Oxidation 2. The Dark Reactions of the Calvin Cycle 1. Gluconeogenesis

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Dave Shechner @shechnerlab.bsky.social · 20/12/2024

Such awesome work from @nandangokhale.bsky.social, @ramlabuw.bsky.social, and colleagues! Fantastic seeing this paradigm-changing study out in the wild. Congrats, everyone!

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Dave Shechner @shechnerlab.bsky.social · 19/12/2024

Good gravy, I have the keyboard shortcuts for all of these memorized, and I just don't know what to do with my life.

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Dave Shechner @shechnerlab.bsky.social · 17/12/2024

Aw, yeah! It’s en-dash time, people!

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Dave Shechner @shechnerlab.bsky.social · 07/12/2024

No joke, I *have* been invited to present my work at a “conference” on food preservation and storage technologies… which I assume would include salted, canned ham.

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Dave Shechner @shechnerlab.bsky.social · 06/12/2024

Oh, they definitely will. I've also seen many protocols (including some commercial kits) that use amine-modified oligos, which are coupled by some sort of sequential coupling rxn. But they all require *gobs* of oligo to synthesize, which gets pricey when you're working with 90mers...

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Dave Shechner @shechnerlab.bsky.social · 06/12/2024

Ooh! This looks quite Interesting; thanks!!

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Dave Shechner @shechnerlab.bsky.social · 06/12/2024

Thanks! I’ll give this a read!

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Dave Shechner @shechnerlab.bsky.social · 06/12/2024

Oh man, Ribosome Display jumps to my mind reliably 2-3x per day. 🤣 But here I feel like it’s overkill.

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Dave Shechner @shechnerlab.bsky.social · 06/12/2024

Alas, it is Cys-free. So we could try to make a recombinant variant with an added Cys, but that becomes a whole project…

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Dave Shechner @shechnerlab.bsky.social · 06/12/2024

Hallo! Does anyone have a robust protocol for coupling DNA oligos to proteins? The oligo will be fairly long, and so protocols that require lower mass inputs are preferred. We have free-rein over the oligo chemistry, but the protein is from a commercial source. Feel free to PM. Thanks in advance! 🙏

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Dave Shechner @shechnerlab.bsky.social · 05/12/2024

<Mind legitimately blown>. *Amazing* work from @aliceyting.bsky.social and colleagues, building programmable, synthetic GPCR’s. Congrats to all authors!!

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