This Perspective discusses the importance of the US Food and Drug Administration’s draft guidance on the use of bayesian methods in clinical trials because it underscores its commitment to modernizing...

Introduction Recent trials have demonstrated that shortened four-month treatment durations are effective for the majority of people with tuberculosis (TB). However, there is a population of TB patient...

Background Safer, more effective treatment regimens for rifampicin-resistant tuberculosis are needed. We evaluated a novel six-month RR-TB treatment strategy. Methods We conducted a phase III,…

Background Tuberculosis services in many settings rely heavily on international donor funding. In 2025, the United States Agency for International Development (USAID) was dismantled, and other countri...

Clinical trials are considered to be the largest contributor to pharmaceutical development costs. However, public disclosure of the costs of individual clinical trials is rare. Médecins Sans Frontiè...

The R2D2 TB Network Consortium has just released a preprint on the first-ever study evaluating the diagnostic accuracy of novel near-point-of-care MTB assays using tongue and sputum swabs for tubercul...

GOOD NEWS: 25% price reduction for pretomanid - price of a BPaLM treatment course is now $310. The vast majority of DR-TB patients should be able to benefit from this shorter, more effective regimen n...

Please note more tickets are now available via the link below. On 24 March each year, the world commemorates the day in 1882 when Dr Robert Koch announced his discovery of Mycobacterium tuberculosis

The Second WHO Global Clinical Trial Forum wrapped up yesterday. More than 100 leaders from across the clinical trials ecosystem came together: Researchers. Funders. Regulators. Ethicists. Private…

Episode #135 / March 21, 2025 / Tuberculosis - TB Severe resource shortages are threatening the global response to end tuberculosis. Is the world on the brink of a global TB crisis? A quarter of the world’s population could be infected with TB and not even know it. Is there a cure?  What is the treatment? How do we diagnose TB? Listen in to Dr Tereza Kasaeva on Science in 5 today. Activez les sous-titres dans VOTRE langue ! ¡Activa los subtítulos en TU idioma! Активируйте субтитры на ВАШЕМ языке! قم بتفعيل الترجمة في لغتك! 激活自动翻译功能，使用您的语言字幕！ Aktivieren Sie Untertitel in IHRER Sprache! Washa manukuu katika lugha YAKO! अपनी भाषा में सबटाइटल सक्रिय करें! You can watch Science in 5 in your language by using the "Auto-translate" feature in YouTube: https://youtu.be/CHsrz1VV--g Activate the subtitles first and then choose your language! Go to bottom right of the video + Settings + Subtitles/CC + Auto-translate and then choose the language of your choice. Some other episodes were also published in these linguistic playlists: Spanish: https://youtube.com/playlist?list=PL6hS8Moik7ktt7QccOeLSyI1agc6yRHjj French: https://youtube.com/playlist?list=PLiIQJ9sPqPFxQyKvHIVxI-mbiTsAI6Six Portuguese: https://youtube.com/playlist?list=PL6hS8Moik7kux2qXeA0jHCNyK4GVorTJM Thai: https://youtube.com/playlist?list=PL9S6xGsoqIBXRQzSDOfFb13iPrbL8fgy1 Nepali: https://youtube.com/playlist?list=PLv3LbY_wohnNmC0c5yAjlyYO-AsKynshD Maithili: https://youtube.com/playlist?list=PLv3LbY_wohnOzLMPfIg4evuGnNUifuaXX Bahasa: https://youtube.com/playlist?list=PLekyghuTrqcaanPy2F-LiW368Emsg1A2J Tetum: https://youtube.com/playlist?list=PLDj7fL7ecKij-CD-4DBTzPwg_tnFUOowt

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Just over a month after US President Donald Trump implemented a 90-day freeze of all foreign assistance, the future looks very uncertain for tuberculosis research. Among others, a large TB research…

Clinical trials have been pivotal to the improvements in public health and clinical care, leading to many millions of additional years of healthy life globally. Some examples of disease areas in which...

Clinical trials have been pivotal to the improvements in public health and clinical care, leading to many millions of additional years of healthy life globally. Some examples of disease areas in which...

For decades, poor treatment options and low-quality evidence plagued care for patients with rifampin-resistant tuberculosis. The advent of new drugs to treat tuberculosis and enhanced funding now p...

In September 2024, WHO published its groundbreaking guidance on best practices for clinical trials - establishing, for the first time, a global framework app...

Background Previously, drug-resistant tuberculosis (DR-TB) patients were treated with long, toxic, and relatively ineffective regimens. However, in recent years, there have been major improvements…