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Sergiu P. Pasca

@sergiuppasca.bsky.social
3.9K followers 2.5K following 315 posts

Professor at Stanford & Director of Stanford Brain Organogenesis Lab: pascalab.org Center: med.stanford.edu/brainorganogenesis… TED: go.ted.com/6WJy Instagram: www.instagram.com/sergiu.p.pasca

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Sergiu P. Pasca @sergiuppasca.bsky.social · 07/10/2026
Thank you for the thoughtful summary and perspective!
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Reposted by Sergiu P. Pasca
Karl Deisseroth @deisseroth.bsky.social · 05/10/2026
Thank you to everyone sharing in this moment! I’m so grateful to all my trainees & collaborators… dlab.stanford.edu/group-members (pic: Peter and I together in 2017) Reading for all those asking: for technical details: dlab.stanford.edu for everyone: deisseroth.org/projections
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Sergiu P. Pasca @sergiuppasca.bsky.social · 01/10/2026
The latest @nature.com editorial discusses oversight as human neural organoid and assembloid research advances, highlighting discussions at Asilomar. An important conversation as the field moves forward. Read more: doi.org/10.1038/d415...
doi.org
Lab-grown brain organoids: time for international oversight
Researchers in the field are right to focus on biosafety, ethics and the involvement of patient groups and the public.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 28/09/2026
The 5th edition of the CSHL meeting on neural #organoids, #assembloids & human development is approaching! Since the first meeting in 2017, this has become a special forum for the field. This edition promises outstanding speakers, strong trainee engagement & the perfect setting to hear the latest
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Sergiu P. Pasca @sergiuppasca.bsky.social · 25/09/2026
www.nature.com/articles/s41...
nature.com
Developmental xenocortication using human-derived organoids in mice - Nature
Xenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 25/09/2026
Here’s a short summary of our recent #xenocortication article in @nature.com, including the rationale, approach, key findings, application to disease modeling & current limitations. A tremendous effort led by Konstantin Kaganovsky, Kevin Kelley, Tilo Gschwind, and Paul Harary. Article below 👇
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Sergiu P. Pasca @sergiuppasca.bsky.social · 24/09/2026
Article here: www.nature.com/articles/s41...
nature.com
mTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis - Nature
Reactive astrocytes emerge as a primary consequence of TSC2 loss in tuberous sclerosis complex, implicating glial dysfunction as a primary driver of pathogenesis and highlighting the astrocytes as pot...
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Sergiu P. Pasca @sergiuppasca.bsky.social · 24/09/2026
Superb work from Helen Bateup’s lab in @nature.com this week, led by the remarkable Tommy Li— a former PhD student at Stanford & lan alumnus. Using regionalized cortical #organoids, they discover glia as major players in tuberous sclerosis.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 18/09/2026
Precisely!
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Sergiu P. Pasca @sergiuppasca.bsky.social · 17/09/2026
thank you!
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Sergiu P. Pasca @sergiuppasca.bsky.social · 17/09/2026
Thank you!
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Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026
article here: www.nature.com/articles/s41...
nature.com
Developmental xenocortication using human-derived organoids in mice - Nature
Xenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026
Nearly seven years in the making. Congratulations to an extraordinary team and wonderful collaborators!
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Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026
We call these #xenocortical mice (XCX).
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Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026
To address some of these limitations and obtain functional readouts relevant to disease biology, we generated #apallial mice, in which ~98% of the cortex & hippocampus fail to form, creating space for transplanted human cortical organoids to grow and integrate extensively.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026
Transplantation can provide a more physiological environment, yet human cortical cells then develop within a rodent brain that matures much faster, constraining their growth and integration.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026
Human neural #assembloids and #organoids have opened new ways to study development in vitro, but they also have important limitations.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026
Today in Nature @nature.com, we report a new approach to studying human brain development and modeling disease in vivo. Open article link below 👇
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Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026
Thank you @carlzimmer.com and @carolynyjohnson.bsky.social for the thoughtful coverage of our work
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Kevin Kelley @kevinkelley.bsky.social · 16/09/2026
9/ Thank you to all co-authors. Really enjoyed working closely with Konstantin, Tilo, Paul Harary. Very grateful to @sergiuppasca.bsky.social for his vision, support, and mentorship. Here is the paper: www.nature.com/articles/s41...
nature.com
Developmental xenocortication using human-derived organoids in mice - Nature
Xenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026
Thank you @nitafarahany.bsky.social Very grateful for the discussions and guidance!
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Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026
Thank you, Kevin! There are many questions about development that we can now begin to address, including what you’ve been proposing for a long time about stochasticity in neural assembly. @wiringthebrain.bsky.social
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Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026
Thank you @anilseth.bsky.social Really appreciate this and your thoughtful perspective on the work.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 10/09/2026
One of the best weeks of the year for us in lab.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 10/09/2026
For us, the course is an invigorating lab-wide effort that we prepare for months in advance. This year it was superbly organized by three outstanding scientists: Merve Avar, Sabina Kanton, and Rebecca Levy (who recently started her own lab at Stanford!).
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Sergiu P. Pasca @sergiuppasca.bsky.social · 10/09/2026
This spring, 22 students came from around the world. They returned to their institutions and labs taking these methods with them and adapting them to their own research.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 10/09/2026
Mornings are devoted to lectures, while afternoons are spent at the bench: going from building assembloids to imaging them and recording their electrical activity. Throughout the week, students also work together in small groups on a project. This year, by popular demand, we focused on assembloids
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Sergiu P. Pasca @sergiuppasca.bsky.social · 10/09/2026
This year, we captured our Stanford Brain Organogenesis Center hand-on workshop on human stem cell models course in action. Every year here on campus , we share methods developed in our lab for generating and applying #organoids and #assembloids. A glimpse of it here: youtu.be/J-TJfdO11AQ?...
youtu.be
Stanford Brain Organogenesis Workshop (2026)
YouTube video by Sergiu Pasca, MD
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Sergiu P. Pasca @sergiuppasca.bsky.social · 28/08/2026
Links to apply below: Clinical Trials Regulatory Lab Manager: fa-exuf-saasfaprod1.fa.ocs.oraclecloud.com/hcmUI/Candid... Clinical Research Coordinator Associate: fa-exuf-saasfaprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...
fa-exuf-saasfaprod1.fa.ocs.oraclecloud.com
Clinical Trials Regulatory Lab Manager
Responsible for ensuring compliance with policies and procedures in accordance with mandated federal laws and regulation for clinical trials and human subjects.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 28/08/2026
Thank you to everyone who shared our Executive Director search last week! As our effort takes off, 2 more positions are now open: a Clinical Trials Regulatory Manager and a Clinical Coordinator Please share with anyone who might be a fit!
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Sergiu P. Pasca @sergiuppasca.bsky.social · 20/08/2026
Apply here: careersearch.stanford.edu/hcmUI/Candid...
careersearch.stanford.edu
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Sergiu P. Pasca @sergiuppasca.bsky.social · 20/08/2026
This is an exciting opportunity to work at the intersection of neuroscience, therapeutics, and clinical translation. More on this effort soon!
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Sergiu P. Pasca @sergiuppasca.bsky.social · 20/08/2026
We are building a new translational effort at focused on advancing therapies for severe neuropsychiatric disorders. We are recruiting an Executive Director to help shape this initiative across @stanfordmedicine.bsky.social and Lucile Packard Children’s Hospital.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 08/07/2026
www.nature.com/articles/s41...
nature.com
CRISPR screens in human neural organoids and assembloids - Nature Protocols
This protocol combines pooled CRISPR–Cas9 screening with neural organoid and assembloid models and illustrates how it can be applied to map hundreds of disease genes onto cellular pathways and specifi...
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Sergiu P. Pasca @sergiuppasca.bsky.social · 08/07/2026
Our article, led by the remarkable Xiangling Meng, on establishing CRISPR screens in neural #assembloids and #organoids is on the cover of Nature Protocols today
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Sergiu P. Pasca @sergiuppasca.bsky.social · 29/06/2026
meetings.cshl.edu/meetings.asp...
meetings.cshl.edu
Development & 3D Modeling of the Human Brain
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 29/06/2026
The 5th edition of the @cshlmeetings conference on Development and Modeling of the Human Brain with #assembloids and #organoids will take place in December. We will have a spectacular group of speakers and a series of selected talks from trainees. Deadline in September. More below 👇
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Sergiu P. Pasca @sergiuppasca.bsky.social · 11/06/2026
Check out this Venice Neuroscience course on #assembloids, which I am co-organizing with @jimena-andersen.bsky.social and @fikri-birey.bsky.social, who developed the initial assembloid system a decade ago. It promises to be a fun week, with a spectacular lineup of speakers and in-depth discussions.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 14/05/2026
This free-of-charge, annual course organized by our @brainorganogenesis.bsky.social Center has helped hundreds of laboratories around the world adopt human stem cell models to study evolution, development, and disease.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 14/05/2026
I am incredibly grateful to my entire lab for teaching this course with such dedication every year, and especially to the 3 superstars directing it: @merveavar.bsky.social & Sabina Kanton & @rebeccalevymdphd.bsky.social !
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Sergiu P. Pasca @sergiuppasca.bsky.social · 14/05/2026
This week we welcome at Stanford a remarkable cohort from all the over the world for our hands-on course on human brain #assembloids & #organoids! Amazing energy as they learn methods developed in the lab over the years, and as we discuss and troubleshoot the projects they are building home.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 02/05/2026
Thank you!
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Reposted by Sergiu P. Pasca
Sarah DeWeerdt @sarahdeweerdt.bsky.social · 01/05/2026
Loved working on this story because it illustrates the interdependence of science: an innovation from one lab unexpectedly clears a roadblock that had stymied another, which then leads to advance that opens up a whole new space for others to explore. Thanks @sergiuppasca.bsky.social for sharing w me
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Sergiu P. Pasca @sergiuppasca.bsky.social · 24/04/2026
Deeply honored to receive the Sir Wilfrid Le Gros Clark Prize, and very grateful for this recognition as I look forward to delivering the lecture at Oxford @ox.ac.uk next week.
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Simon Fisher @profsimonfisher.bsky.social · 08/04/2026
“Over the next decade these stem-cell-based models will increasingly help reveal the biology of complex brain conditions & demystify diseases that have long remained inaccessible” says organoid guru @sergiuppasca.bsky.social in this Nature news piece on an elegant & beautiful area of modern science🧪
nature.com
Mini models of the human brain are revealing how this complex organ takes shape
Lab-grown organoids are turbo-charging the study of human brain development and disease.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 02/04/2026
careersearch.stanford.edu/jobs/life-sc...
careersearch.stanford.edu
Life Science Research Professional 2 (1 YR FIXED -TERM) in School of Medicine, Stanford, California, United States
The Department of Psychiatry and Behavioral Sciences at Stanford University School of Medicine is seeking a highly motivated Life Science Research...
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Sergiu P. Pasca @sergiuppasca.bsky.social · 02/04/2026
Several staff scientist positions available in our lab at Stanford University! More details and application at the link below
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Sergiu P. Pasca @sergiuppasca.bsky.social · 11/03/2026
article here: www.biorxiv.org/content/10.6...
biorxiv.org
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Sergiu P. Pasca @sergiuppasca.bsky.social · 11/03/2026
Video above depicts responses to serotonin of neurons in human cortical organoids captured with the PsychLight2 sensor.
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Sergiu P. Pasca @sergiuppasca.bsky.social · 11/03/2026
This work was led by a incredible group of scientists in lab: Sabina Kanton, Meng XiangLing, Chunyang Dong, Fikri Birey.
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