Sergiu P. Pasca @sergiuppasca.bsky.social · 07/10/2026Thank you for the thoughtful summary and perspective! 040
Reposted by Sergiu P. PascaKarl Deisseroth @deisseroth.bsky.social · 05/10/2026Thank you to everyone sharing in this moment! I’m so grateful to all my trainees & collaborators… dlab.stanford.edu/group-members (pic: Peter and I together in 2017) Reading for all those asking: for technical details: dlab.stanford.edu for everyone: deisseroth.org/projections 521573298
Sergiu P. Pasca @sergiuppasca.bsky.social · 01/10/2026The latest @nature.com editorial discusses oversight as human neural organoid and assembloid research advances, highlighting discussions at Asilomar. An important conversation as the field moves forward. Read more: doi.org/10.1038/d415...doi.orgLab-grown brain organoids: time for international oversightResearchers in the field are right to focus on biosafety, ethics and the involvement of patient groups and the public. 065
Sergiu P. Pasca @sergiuppasca.bsky.social · 28/09/2026The 5th edition of the CSHL meeting on neural #organoids, #assembloids & human development is approaching! Since the first meeting in 2017, this has become a special forum for the field. This edition promises outstanding speakers, strong trainee engagement & the perfect setting to hear the latest 0115
Sergiu P. Pasca @sergiuppasca.bsky.social · 25/09/2026www.nature.com/articles/s41...nature.comDevelopmental xenocortication using human-derived organoids in mice - NatureXenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice. 010
Sergiu P. Pasca @sergiuppasca.bsky.social · 25/09/2026Here’s a short summary of our recent #xenocortication article in @nature.com, including the rationale, approach, key findings, application to disease modeling & current limitations. A tremendous effort led by Konstantin Kaganovsky, Kevin Kelley, Tilo Gschwind, and Paul Harary. Article below 👇 171
Sergiu P. Pasca @sergiuppasca.bsky.social · 24/09/2026Article here: www.nature.com/articles/s41...nature.commTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis - NatureReactive astrocytes emerge as a primary consequence of TSC2 loss in tuberous sclerosis complex, implicating glial dysfunction as a primary driver of pathogenesis and highlighting the astrocytes as pot... 031
Sergiu P. Pasca @sergiuppasca.bsky.social · 24/09/2026Superb work from Helen Bateup’s lab in @nature.com this week, led by the remarkable Tommy Li— a former PhD student at Stanford & lan alumnus. Using regionalized cortical #organoids, they discover glia as major players in tuberous sclerosis. 171
Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026article here: www.nature.com/articles/s41...nature.comDevelopmental xenocortication using human-derived organoids in mice - NatureXenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice. 070
Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026Nearly seven years in the making. Congratulations to an extraordinary team and wonderful collaborators! 140
Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026To address some of these limitations and obtain functional readouts relevant to disease biology, we generated #apallial mice, in which ~98% of the cortex & hippocampus fail to form, creating space for transplanted human cortical organoids to grow and integrate extensively. 140
Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026Transplantation can provide a more physiological environment, yet human cortical cells then develop within a rodent brain that matures much faster, constraining their growth and integration. 130
Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026Human neural #assembloids and #organoids have opened new ways to study development in vitro, but they also have important limitations. 120
Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026Today in Nature @nature.com, we report a new approach to studying human brain development and modeling disease in vivo. Open article link below 👇 49232
Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026Thank you @carlzimmer.com and @carolynyjohnson.bsky.social for the thoughtful coverage of our work 180
Reposted by Sergiu P. PascaKevin Kelley @kevinkelley.bsky.social · 16/09/20269/ Thank you to all co-authors. Really enjoyed working closely with Konstantin, Tilo, Paul Harary. Very grateful to @sergiuppasca.bsky.social for his vision, support, and mentorship. Here is the paper: www.nature.com/articles/s41...nature.comDevelopmental xenocortication using human-derived organoids in mice - NatureXenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice. 251
Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026Thank you @nitafarahany.bsky.social Very grateful for the discussions and guidance! 040
Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026Thank you, Kevin! There are many questions about development that we can now begin to address, including what you’ve been proposing for a long time about stochasticity in neural assembly. @wiringthebrain.bsky.social 0101
Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026Thank you @anilseth.bsky.social Really appreciate this and your thoughtful perspective on the work. 2140
Sergiu P. Pasca @sergiuppasca.bsky.social · 10/09/2026One of the best weeks of the year for us in lab. 040
Sergiu P. Pasca @sergiuppasca.bsky.social · 10/09/2026For us, the course is an invigorating lab-wide effort that we prepare for months in advance. This year it was superbly organized by three outstanding scientists: Merve Avar, Sabina Kanton, and Rebecca Levy (who recently started her own lab at Stanford!). 130
Sergiu P. Pasca @sergiuppasca.bsky.social · 10/09/2026This spring, 22 students came from around the world. They returned to their institutions and labs taking these methods with them and adapting them to their own research. 120
Sergiu P. Pasca @sergiuppasca.bsky.social · 10/09/2026Mornings are devoted to lectures, while afternoons are spent at the bench: going from building assembloids to imaging them and recording their electrical activity. Throughout the week, students also work together in small groups on a project. This year, by popular demand, we focused on assembloids 110
Sergiu P. Pasca @sergiuppasca.bsky.social · 10/09/2026This year, we captured our Stanford Brain Organogenesis Center hand-on workshop on human stem cell models course in action. Every year here on campus , we share methods developed in our lab for generating and applying #organoids and #assembloids. A glimpse of it here: youtu.be/J-TJfdO11AQ?...youtu.beStanford Brain Organogenesis Workshop (2026)YouTube video by Sergiu Pasca, MD 1141
Sergiu P. Pasca @sergiuppasca.bsky.social · 28/08/2026Links to apply below: Clinical Trials Regulatory Lab Manager: fa-exuf-saasfaprod1.fa.ocs.oraclecloud.com/hcmUI/Candid... Clinical Research Coordinator Associate: fa-exuf-saasfaprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...fa-exuf-saasfaprod1.fa.ocs.oraclecloud.comClinical Trials Regulatory Lab ManagerResponsible for ensuring compliance with policies and procedures in accordance with mandated federal laws and regulation for clinical trials and human subjects. 000
Sergiu P. Pasca @sergiuppasca.bsky.social · 28/08/2026Thank you to everyone who shared our Executive Director search last week! As our effort takes off, 2 more positions are now open: a Clinical Trials Regulatory Manager and a Clinical Coordinator Please share with anyone who might be a fit! 231
Sergiu P. Pasca @sergiuppasca.bsky.social · 20/08/2026Apply here: careersearch.stanford.edu/hcmUI/Candid...careersearch.stanford.edu 000
Sergiu P. Pasca @sergiuppasca.bsky.social · 20/08/2026This is an exciting opportunity to work at the intersection of neuroscience, therapeutics, and clinical translation. More on this effort soon! 120
Sergiu P. Pasca @sergiuppasca.bsky.social · 20/08/2026We are building a new translational effort at focused on advancing therapies for severe neuropsychiatric disorders. We are recruiting an Executive Director to help shape this initiative across @stanfordmedicine.bsky.social and Lucile Packard Children’s Hospital. 152
Sergiu P. Pasca @sergiuppasca.bsky.social · 08/07/2026www.nature.com/articles/s41...nature.comCRISPR screens in human neural organoids and assembloids - Nature ProtocolsThis protocol combines pooled CRISPR–Cas9 screening with neural organoid and assembloid models and illustrates how it can be applied to map hundreds of disease genes onto cellular pathways and specifi... 050
Sergiu P. Pasca @sergiuppasca.bsky.social · 08/07/2026Our article, led by the remarkable Xiangling Meng, on establishing CRISPR screens in neural #assembloids and #organoids is on the cover of Nature Protocols today 2182
Sergiu P. Pasca @sergiuppasca.bsky.social · 29/06/2026meetings.cshl.edu/meetings.asp...meetings.cshl.eduDevelopment & 3D Modeling of the Human BrainCold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics. 110
Sergiu P. Pasca @sergiuppasca.bsky.social · 29/06/2026The 5th edition of the @cshlmeetings conference on Development and Modeling of the Human Brain with #assembloids and #organoids will take place in December. We will have a spectacular group of speakers and a series of selected talks from trainees. Deadline in September. More below 👇 151
Sergiu P. Pasca @sergiuppasca.bsky.social · 11/06/2026Check out this Venice Neuroscience course on #assembloids, which I am co-organizing with @jimena-andersen.bsky.social and @fikri-birey.bsky.social, who developed the initial assembloid system a decade ago. It promises to be a fun week, with a spectacular lineup of speakers and in-depth discussions. 154
Sergiu P. Pasca @sergiuppasca.bsky.social · 14/05/2026This free-of-charge, annual course organized by our @brainorganogenesis.bsky.social Center has helped hundreds of laboratories around the world adopt human stem cell models to study evolution, development, and disease. 030
Sergiu P. Pasca @sergiuppasca.bsky.social · 14/05/2026I am incredibly grateful to my entire lab for teaching this course with such dedication every year, and especially to the 3 superstars directing it: @merveavar.bsky.social & Sabina Kanton & @rebeccalevymdphd.bsky.social ! 110
Sergiu P. Pasca @sergiuppasca.bsky.social · 14/05/2026This week we welcome at Stanford a remarkable cohort from all the over the world for our hands-on course on human brain #assembloids & #organoids! Amazing energy as they learn methods developed in the lab over the years, and as we discuss and troubleshoot the projects they are building home. 1151
Reposted by Sergiu P. PascaSarah DeWeerdt @sarahdeweerdt.bsky.social · 01/05/2026Loved working on this story because it illustrates the interdependence of science: an innovation from one lab unexpectedly clears a roadblock that had stymied another, which then leads to advance that opens up a whole new space for others to explore. Thanks @sergiuppasca.bsky.social for sharing w me 193
Sergiu P. Pasca @sergiuppasca.bsky.social · 24/04/2026Deeply honored to receive the Sir Wilfrid Le Gros Clark Prize, and very grateful for this recognition as I look forward to delivering the lecture at Oxford @ox.ac.uk next week. 3100
Reposted by Sergiu P. PascaSimon Fisher @profsimonfisher.bsky.social · 08/04/2026“Over the next decade these stem-cell-based models will increasingly help reveal the biology of complex brain conditions & demystify diseases that have long remained inaccessible” says organoid guru @sergiuppasca.bsky.social in this Nature news piece on an elegant & beautiful area of modern science🧪nature.comMini models of the human brain are revealing how this complex organ takes shapeLab-grown organoids are turbo-charging the study of human brain development and disease. 0249
Sergiu P. Pasca @sergiuppasca.bsky.social · 02/04/2026careersearch.stanford.edu/jobs/life-sc...careersearch.stanford.eduLife Science Research Professional 2 (1 YR FIXED -TERM) in School of Medicine, Stanford, California, United StatesThe Department of Psychiatry and Behavioral Sciences at Stanford University School of Medicine is seeking a highly motivated Life Science Research... 010
Sergiu P. Pasca @sergiuppasca.bsky.social · 02/04/2026Several staff scientist positions available in our lab at Stanford University! More details and application at the link below 183
Sergiu P. Pasca @sergiuppasca.bsky.social · 11/03/2026article here: www.biorxiv.org/content/10.6...biorxiv.org 033
Sergiu P. Pasca @sergiuppasca.bsky.social · 11/03/2026Video above depicts responses to serotonin of neurons in human cortical organoids captured with the PsychLight2 sensor. 100
Sergiu P. Pasca @sergiuppasca.bsky.social · 11/03/2026This work was led by a incredible group of scientists in lab: Sabina Kanton, Meng XiangLing, Chunyang Dong, Fikri Birey. 120