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Sharon Plon

@seplon.bsky.social
883 followers 78 following 271 posts

Geneticist, researcher and educator

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Reposted by Sharon Plon
From the Labs at Baylor College of Medicine @bcmfromthelabs.bsky.social · 28/09/2026
Integrating multiple approaches allowed H. Bellen, M. Deng, M. Wangler et al. to diagnosis a rare, complex #neurodevelopmentalDisorder. @ajhgnews.bsky.social @bcmhouston.bsky.social @bcmgenetics.bsky.social @TexomeProject #BRSK1 #fruitfly www.bcm.edu/news/togethe...
bcm.edu
Together human genetics, AI and animal studies provide diagnosis for rare, complex neurodevelopmental disorder
Researchers at Baylor College of Medicine, the Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital, the Texome Project and...
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Reposted by Sharon Plon
eliderp10.bsky.social @eliderp10.bsky.social · 26/09/2026
We talked to eRA and NCBI and they were useless. No one knows anything about WHO did this or when. Good times, GOLD STANDARD!
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Sharon Plon @seplon.bsky.social · 25/09/2026
Very important description of the problems with the new restrictions on K awards and the future development of clinician-scientists.
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Sharon Plon @seplon.bsky.social · 25/09/2026
On Becoming a Gold Standard Scientist jamanetwork.com/journals/jam...
jamanetwork.com
On Becoming a Gold Standard Scientist
This Viewpoint discusses the recent National Institutes of Health announcement that its Career Development (K) awards cannot be used to conduct clinical trials, feasibility studies, or ancillary studi...
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Reposted by Sharon Plon
Baylor College of Medicine @bcmhouston.bsky.social · 24/09/2026
A 3-year-old boy’s quick-spreading cancer is cured thanks to 2 doses of a new experimental treatment. #CancerResearch
bit.ly
3-year-old boy’s quick-spreading cancer is cured thanks to 2 doses of new treatment
While CAR T-cell therapy has shown promising effects on blood cancers, its effects are limited when treating solid tumors, until now.
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Sharon Plon @seplon.bsky.social · 26/08/2026
I remember when Geoff first applied to our MD-PHD program @bcm and wanted to use science to improve the health of children with malnutrition. Gratifying to see years later his own lab’s work now paying off. Support of physician-scientists is a long process with big rewards.
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Sharon Plon @seplon.bsky.social · 26/08/2026
Delighted to see the thesis work from graduate student Suhasini Lulla published this week. Asked a basic question based on the two-hit hypothesis and found a surprising result. Germline first hits are distinct from somatic ones! Open access.
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Sharon Plon @seplon.bsky.social · 29/07/2026
If you haven’t seen The Odyssey yet consider bringing ear plugs or AirPods. Liked the movie but ears are ringing and have a headache afterwards
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Reposted by Sharon Plon
@debbie156 @debbie156.bsky.social · 26/07/2026
Meet the amazing Mary Golda Ross. She was a trailblazing Cherokee/American mathematician and engineer, & Lockheed’s first female that designed secret missile programs. Brilliant & amazing! #Pinks #SheShed #ProudBlue #OneV1 airandspace.si.edu/stories/edit...
airandspace.si.edu
Mary Golda Ross: Aerospace Engineer, Educator, and Advocate
Engineer Mary Golda Ross made lasting contributions to the United States aerospace industry while opening doors for women and Native students to pursue S.T.E.M. education and careers.
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Sharon Plon @seplon.bsky.social · 26/01/2026
I was trying to find an article for a family member with lung cancer that I knew I read in last few months in New England Journal on a clinical trial. (1) First went to NEJM website since I subscribe - no luck searching on lung cancer, failed EGFR, Chinese (site of study), 1/4
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Sharon Plon @seplon.bsky.social · 20/12/2025
Can anyone figure out this spam. A real person called my husband’s cell twice saying he was getting calls from him. The person read out my husband’s cell even though he never called him. That happens. The strange part is that when the person called my husband it showed MY cell phone number twice!!
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Sharon Plon @seplon.bsky.social · 11/11/2025
Happy to report that the results of germline testing as part of the National Cancer Institute/Children’s Oncology Group MATCH precision oncology trial was published. pubmed.ncbi.nlm.nih.gov/41166674/
pubmed.ncbi.nlm.nih.gov
Germline Cancer Predisposition Results From the National Cancer Institute-Children's Oncology Group Pediatric MATCH Trial - PubMed
Coordinated germline and tumor panel testing was feasible and revealed P/LP CPG variants in 6.3% of the Pediatric MATCH cohort. Tumor variant fraction, germline association of CPG with tumor type, and adult-oriented guidelines were not predictive of germline status, emphasizing the need for systemat …
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Reposted by Sharon Plon
Chris Gunter 🧬 @girlscientist.bsky.social · 14/10/2025
Welcome to #ASHG25! As our President Sarah Tishkoff just noted, next year for the first time the ASHG exec cmte will be all women. Glad to have anyone and everyone participating in this society now and in the future.
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Claudia Gonzaga-Jauregui @cgonzagaj.bsky.social · 14/10/2025
First Plenary Abstract Session of #ASHG25 starting with Srikar Gopinath from Yale describing their study characterizing >1M variants in the 5' UTR regions to assess their functional effects on gene translation and develop a prediction algorithm to evaluate non-coding UTR variation.
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Sharon Plon @seplon.bsky.social · 15/10/2025
Congratulations to Andy Rivera @poseypod.bsky.social lab @bcmhouston.bsky.social grad student for putting together a standing room only session at #ASHG25
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Sharon Plon @seplon.bsky.social · 17/07/2025
@nickywhiffin.bsky.social An article I thought you would appreciate. www.bozemandailychronicle.com/news/renu-sy...
bozemandailychronicle.com
‘We finally have a name’: At long last, Manhattan family gets an answer to daughter's rare genetic condition
As with so many calls previously about 9-year-old Delilah, Kelli Stanley braced for more uncertainty. But this time was different. This time, they finally had a name.
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Reposted by Sharon Plon
Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 13/07/2025
“The cause defended at Dayton is a continuing one that has existed throughout man’s brief history and will continue as long as man is here,” Scopes wrote in Center of the Storm, his 1967 memoir. “It is the cause of freedom, for which man must do what he can.”
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Sharon Plon @seplon.bsky.social · 25/06/2025
Funny reversal of technology. I have received the print version of @nejm.org for >30 years. I get the hard copy at my house. I wanted to look at videos associated with article in June 26 issue I was reading today on Pompe disease. I can read the print version - but the digital issue is not online!!
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Reposted by Sharon Plon
euanashley @euanashley.bsky.social · 14/06/2025
Atul Butte died yesterday. The world lost a giant. A big bear of a man. With a huge smile. With love for everyone. With energy that could power a room. I loved everything about Atul. I loved how he was always happy. I loved how excited he was about science and helping people.
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Larry Hunter @proflhunter.bsky.social · 13/06/2025
In a modest bit of good news, NIH has released new NOFOs for all the NRSAs (and also Pioneer and New Innovator awards) grants.nih.gov/funding/nih-...
grants.nih.gov
NIH Guide for Grants and Contracts | Grants & Funding
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Reposted by Sharon Plon
Aaron Rupar @atrupar.com · 10/06/2025
Durbin to Bhattacharya: "I can't understand it. I disagree w/ this admin on so many things. But this is the one that really gets to me personally. To think this nation would walk away from medical research. For God's sake...cancer, your budget requests a 38% cut to the National Cancer Institute"
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Alex Rubinsteyn @alexr.bsky.social · 05/06/2025
That’s awesome! ….but, it’s also ~30 R01s The truth is that the US stood alone in large scale science funding— and reaped a lot of benefit for being -the- place where new things get discovered Realigning is going to be tough on everyone
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Harmit Singh Malik @harmitmalik.bsky.social · 05/06/2025
The fallacy posed by the MAHAers is that if you eat healthy you are not going to be afflicted by diseases such as cancer. This is not just statistically stupid but it’s also cruel. Imagine telling the parent of a young child with cancer that you should have eaten more veggies. 1/
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Sharon Plon @seplon.bsky.social · 27/05/2025
At the luncheon for our Baylor College of Medicine MD/PhD MSTP graduation reception. So proud of this group and what they have accomplished!! Heading off during challenging times!
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Reposted by Sharon Plon
Turvey Lab @turveylab.bsky.social · 20/05/2025
📢📢Published today in @jem.org 📢📢 New human inborn error of immunity. We describe the first reported human with a monogenic disorder caused by the disruption of ZBTB7B, which encodes the transcription factor ThPOK. rupress.org/jem/article/... @ubcmedicine.bsky.social @bcchresearch.bsky.social
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Sharon Plon @seplon.bsky.social · 20/05/2025
Stefan Pfister - KiTZ Heidelberg Genomics of pediatric tumors. What makes childhood brain tumors different (recent publication) and new data. Pediatric hallmarks of cancer. Don’t have environmental exposure but have hijacking of normal development (maturation block) and simple genomes. #MSKDevOnc
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Sharon Plon @seplon.bsky.social · 20/05/2025
Richard Phillips - UPenn - epigenetic dysregulation of midline brain tumors. Different epigenetic regulator changes with age. Where K3.1 K27M is much younger than K3.3G34R/V tumors. IDH mutant is even older adults. Vulnerable periods of plasticity may differ. #MSKDevOnc #MSKkids
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Sharon Plon @seplon.bsky.social · 20/05/2025
Piyush Joshi - German Cancer Research Center. Plasticity of Medulloblastoma Group 3/4. See overlapping molecular programs across subtypes. Single nucleus multi-omic experiments. Transcription factor network. #MSKDevOnc #MSKkids
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Sharon Plon @seplon.bsky.social · 20/05/2025
David Teachey - CHOP on pediatric ALL treatment. Most of initial treatments developed in 1950’s. Hit a threshold with standard CTX in COG trials that ended in the 90’s, Focus on T-ALL - one good shot for initial treatment. Relapse not very successful. Need to improve frontline #MSKDevOnc #MSKkids
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Sharon Plon @seplon.bsky.social · 20/05/2025
Jean Soulier - France Genomic Instability in MDS/Fanconi Anemia begins Day 2 of the Steel Symposium. Now up to 24 genes. See both MDS and AML with subsequent in adults get solid tumors H&N SCC. Aldehydes one cause of inter strand crosslinks. #MSKDevOnc #MSKkids
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Sharon Plon @seplon.bsky.social · 19/05/2025
Paul Northcott - St. Jude - reviewing the history of the Medulloblastoma molecular anlaysis. 4 groups go back to many papers in 2006 to 2011. 2016 WHO classification separate out these diseases. Origins of MB for Group 3 & 4. #MSKDevOnc #MSKkids
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Sharon Plon @seplon.bsky.social · 19/05/2025
Pallavi Mohapatra - Huangfu and Ziv labs. Pancreatic Neuroendocrine tumors. Highly heterogeneous depending on the type of Islet cells and the hormone expressed (10-40% of tumors). Remainder are non-expressing and diagnosed very extensive. Lack of targeted therapeutic options. #MSKDevOnc #MSKkids
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Sharon Plon @seplon.bsky.social · 19/05/2025
Taryn Treger - UK - Wilms Tumor genetic predisposition. Compared WGS to 71 children with Wilms tumor with some known anomalies and similar number that were “negative”. Look at what is missed by standard analysis. #MSKDevOnc #MSKkids
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Sharon Plon @seplon.bsky.social · 19/05/2025
Elena Vasileva - Amatruda Lab at Children’s Hospital LA. Working on molecular genetics of Ewing sarcoma. No previously available mouse genetic model. EWS-Fli is very toxic in mouse cells. Using Zebrafish as a mosaic model instead. Inducible model (Elife, 2022). #MSKDevOnc #MSKkids
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Sharon Plon @seplon.bsky.social · 19/05/2025
Asher Steinberg - Kentsis lab Long read sequencing of sarcomas. Osteosarcoma high number of rearrangements but few point mutations. Doing long-read RNA sequencing to capture different isoforms by looking at splice junctions to get better patterns than short reads. #MSKDevOnc #MSKkids
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Sharon Plon @seplon.bsky.social · 19/05/2025
Lauren Banks - MSKCC - breaking HLA restriction and using TCR to attack intracellular antigen. Desmoplastic small cell round cell tumor. EWSR1-WT1 defines this tumor type. Conserved exon sequence of fusion RNA. So have a specific and unique junction peptide fragment. #MSKDevOnc #MSKkids
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Sharon Plon @seplon.bsky.social · 19/05/2025
Takeshi Fujino - MSKCC Pharmacology. Taking on Development of CAR-T cells targeting U5 snRNP200 for AML and b-lymphoid malignancies. Anti-U5 snRNP200 antibodies are being used. U5 snRNP200 is an RNA helicase part of the spliceosome. #MSKDevOnc #MSKkids
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Sharon Plon @seplon.bsky.social · 19/05/2025
Isabella Kong - Roth Lab - Weill Cornell Medicine. EBV-associated lymphoma. EBV latency states in malignancies. Latency 2 and 3 more likely to be killed by EBV specific killing. Latency 1 tumors don’t express antigens. Get partial conversion from latency 1 tumors by decitabine. #MSKDevOnc #MSKkids
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Sharon Plon @seplon.bsky.social · 19/05/2025
Cath Bollard - National Children’s Hospital - talking history of immunotherapy. Cancer Grand Challenge Team to increase potency T-cells for childhood cancer (solid tumors). 6 work packages and 3 clinical trials planned #MSKDevOnc #MSKkids
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Sharon Plon @seplon.bsky.social · 19/05/2025
Karina Leung - MSKCC Pre-targeted 225Ac alpha emitters radioImmunotherapy using self-assembling Dis-assembling bispecific antibodies. Focus on neuroblastoma. Alpha particles +2 high LET inducing double strand breaks #MSKDevOnc #MSKkids
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Sharon Plon @seplon.bsky.social · 19/05/2025
Oriana Miltiadous - MSKCC next up studying microbiome in pediatric cancer. Prior evidence that response to immune therapy impacted by microbiome species. How does antibiotics impact this? #MSKDevOnc #MSKkids
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Sharon Plon @seplon.bsky.social · 19/05/2025
Urmila Sehrawat on eIF4A target for MYC-driven neuroblastoma. eIF4A is overexpressed. Looking at natural products and synthetic analogs to find optimal inhibitors. #MSKDevOnc #MSKkids
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Sharon Plon @seplon.bsky.social · 19/05/2025
First up is Marielle Filbin from DFCI, Boston Children’s on glioma development, pediatric high grade glioma and ependymoma. Reviewing the amazing specificity of H3.3 K27M or H3.1K27M mutations in midline tumors. #MSKDevOnc
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Sharon Plon @seplon.bsky.social · 19/05/2025
I’m in NYC at the 2025 Robert Steel Symposium in Developmental Oncology. #MSKDevOnc and posting is allowed. mskcc.cloud-cme.com/Assets/mskcc...
mskcc.cloud-cme.com
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Sharon Plon @seplon.bsky.social · 11/05/2025
Garden friends. Have grown orchids in this corner of my living room for years. Now two different plants are losing leaves. Often starts like this. Any ideas?🌱🌱
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Prof Peter Hotez MD PhD DSc(hon) @peterhotezmdphd.bsky.social · 01/05/2025
1/n I don’t understand the new Dept HHS assertion that childhood vaccines weren’t tested in placebo-controlled trials. That’s simply not true. I did a quick (non-exhaustive) PubMed search and they came up pretty quickly. For example here’s MMR
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Nicky Whiffin @nickywhiffin.bsky.social · 03/03/2025
I don’t normally criticise papers publicly and have hesitated before posting this 🧵. However, I worry about the potential implications of this paper and others that may make similar mistakes. The paper: www.nature.com/articles/s41... 1/7
nature.com
Expanding the mutational spectrum of ReNU syndrome: insights into 5’ Stem-loop variants - European Journal of Human Genetics
European Journal of Human Genetics - Expanding the mutational spectrum of ReNU syndrome: insights into 5’ Stem-loop variants
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Kaia Mattioli @kaiamattioli.bsky.social · 28/04/2025
i'm just a senior postdoc, standing in front of a career that i have worked really hard for, asking higher education in the united states to not completely implode in front of my eyes before i even get a chance to say the words 'my lab studies'
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Sharon Plon @seplon.bsky.social · 28/04/2025
Filbin - profiling of ependymoma (pediatric brain tumor). Well known ZFTA-RELA and other fusions in supratentorial ependymoma (ST-EPN). Now in bioarchive but doesn’t want posted??? Really don’t get the posting ideas at the meeting this year #AACR2025
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Marlowe Tessmer @marlowetessmer.bsky.social · 26/04/2025
Check out this thread from @seplon.bsky.social and then go see the pediatric cancer series here brnw.ch/21wSeVa #AACR25
brnw.ch
Pediatric Oncology Series | Clinical Cancer Research | American Association for Cancer Research
Clinical Cancer Research is proud to present an updated special collection of articles from the AACR Childhood Cancer Predisposition Workshop. The series o
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