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Cyril Seillet, PhD

@seilletlab.bsky.social
40 followers 35 following 3 posts

Immunologist, NHMRC Fellow & Lab Head, Integrated Mucosal Immunity Lab @MonashUni

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Reposted by Cyril Seillet, PhD
Putoczki Lab @putoczkilab.bsky.social · 06/06/2025
We're looking for a post-doc to join our team @wehi-research.bsky.social The project is fast paced and challenging, but its going to be a ton of fun! Apply now and please spread the word wehi.wd3.myworkdayjobs.com/broadbean_ex....
wehi.wd3.myworkdayjobs.com
Senior Research Officer
Job Title Senior Research Officer Job Description An exciting opportunity exists for a talented and commercially focused researcher with a strong interest in immunology to join the Putoczki Laboratory...
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Cyril Seillet, PhD @seilletlab.bsky.social · 06/06/2025
Interesting approach from Chao Zhong’s group to dissect the role of RORgt in activated ILC3 highlighting its essential function in driving HB-EGF expression, rather than IL-22. www.cell.com/cell-reports...
cell.com
RORγt is crucial for gut homeostasis by regulating the expression of HB-EGF rather than IL-22 in activated ILC3s
Li et al. show that RORγt, the ILC3 master regulator, still plays a crucial role during the ILC3 activation phase. Although it is dispensable for ILC3 maintenance and their IL-22 production, it is req...
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Reposted by Cyril Seillet, PhD
Patrick Veiga @patrickveiga.bsky.social · 04/06/2025
Thrilled to share our latest review on how the gut microbiome connects diet to health, now published in Nature Reviews Gastro & Hepa! Honored to co-sign this piece with outstanding PIs @eranelinav.bsky.social @jfcryan.bsky.social Yolanda Sanz Mélanie Deschasaux Rebekka Lambrecht rdcu.be/epret
rdcu.be
The gut microbiome connects nutrition and human health
Nature Reviews Gastroenterology & Hepatology - In this Review, Sanz and colleagues discuss how diet shapes the gut microbiome, the role of diet–microbiome interactions on the immune,...
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Reposted by Cyril Seillet, PhD
Nature Reviews Immunology @natrevimmunol.nature.com · 29/05/2025
Not one, not two .... but FIVE recent papers highlighting a role for RORgt+ antigen-presenting cells in the gut in establishing tolerance to food antigens #oraltolerance #immunosky #foodallergy
nature.com
RORγt+ antigen-presenting cells mediate food tolerance - Nature Reviews Immunology
Five recent papers identify the RORγt+ antigen-presenting cells that induce food-antigen-specific regulatory T cells and establish food tolerance.
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Cyril Seillet, PhD @seilletlab.bsky.social · 02/06/2025
🎓 PhD positions available @MonashUni Join our lab to explore how neurons and immune cells shape gut immunity! 🧬 Single-cell RNAseq 🔬 3D imaging 🧠 Neuro-immune interactions 👥 Great mentoring & collaborations Apply now 👉 tinyurl.com/Seilletlab
tinyurl.com
Understanding the neuroimmune regulation of innate immunity | Supervisor Connect
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Reposted by Cyril Seillet, PhD
Joanna Groom @groomlab.bsky.social · 09/05/2025
Excited to have our latest research published in @jem.org this week and also highlighted by @natrevimmunol.nature.com @wehi-research.bsky.social @benjbroom.bsky.social
nature.com
Brief blockade of type I IFN increases CD8+ T cell memory - Nature Reviews Immunology
A study shows that transient blockade of type I interferon signalling during T cell priming enhances the generation of stem cell-like memory CD8+ T cells after viral infection and mRNA vaccination.
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Reposted by Cyril Seillet, PhD
Le Xiong @lexiong.bsky.social · 18/05/2025
Excited to see our work published on @cp-immunity.bsky.social. Also shared by a nice commentary. really like the last sentence: “Not all fuel nourishes; some, once ignited, may burn beyond control.”
cell.com
Dietary fuel or fire: Fatty acids rewire gut ILC3s
Long-term consumption of diets high in fats has detrimental impacts on the immune system, but the window necessary for initiating these effects is unclear. In this issue of Immunity, Xiong et al. demo...
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Reposted by Cyril Seillet, PhD
Le Xiong @lexiong.bsky.social · 15/04/2025
Thrilled to share our work now published on @cp-immunity.bsky.social . Big thanks to our collaborators. Here we show that short-term High-Fat diet impairs ILC3 functions in producing IL-22 through microbiota-dependent and-independent mechanisms.
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Reposted by Cyril Seillet, PhD
WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 19/05/2025
A landmark WEHI-led study has uncovered how our daily food choices are having an immediate effect on our gut health. Brilliant research led byDr Cyril Seillet and Dr Le Xiong, that could help pinpoint #chronicinflammation at the source. Now published in Immunity. www.wehi.edu.au/news/fast-fo...
Innate lymphoid cells 3 (ILC3s) are a subset of immune cells that are critical to gut immunity. When there is excess fat, such as after a rich meal, ILC3s store this fat in tiny lipid droplets to maintain their function. In this 3D illustration, we can see a lipid droplet (in orange) inside an ILC3.
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Cyril Seillet, PhD @seilletlab.bsky.social · 19/05/2025
🧠🍔 Just 48 hours on a high-fat diet can weaken gut immunity. Our new study shows saturated fats rapidly impair ILC3s! Proud to see this featured by @wehi-research.bsky.social as I continue to explore these questions @monashuniversity.bsky.social with the IMI Lab!
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