iiinova — where your digital self keeps evolving

Seeger Lab @seegerlab.bsky.social · 21/04/2026

Congrats to Fabian Ackle (@fabianackle.ch) for successfully defending his PhD thesis! 🥳👩‍🎓 You did an excellent job setting up and driving this project forward! We’ve always admired your curiosity and passion for science! We’re so proud of you! ☺️

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Stephan Gruber @gruberlab.bsky.social · 20/10/2025

This was a fun collaboration between Ophélie & the @seegerlab.bsky.social using sybody libraries to target the SMC complex in living bacteria. With a suprising finding: the 14 isolated sybodies bind to the middle of the SMC coiled coil rather than the more conserved ATPase heads.

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Camilo Perez @camiloperezc6h6.bsky.social · 21/08/2025

We are hiring a Postdoc in membrane protein cryo-EM at the University of Georgia. Looking for candidates with expertise in membrane protein purification and biochemistry. Fully funded for up to 5 years. Join us in Athens, GA. Apply: camilo.perez@uga.edu

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Carolyn King @immunologyking.bsky.social · 20/08/2025

always a pleasure discussing all things #tuberculosis with this group @seegerlab.bsky.social @berndwollscheid.bsky.social & Michael Berney

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Arne Möller @arnemoeller.bsky.social · 28/04/2025

Dear all, I am very excited about the upcoming 842 WE-Heraeus-Seminar #Cryo-EM on the Move. @djanuliene.bsky.social and I are looking forward to a great conference with many exciting speakers!

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ABC2025 @abcmeeting.bsky.social · 07/03/2025

We had an amazing time with the ABC family and already miss you all! Can’t wait to hear your exciting talks, have great discussions, and hit the slopes of the Alps again. #ABC2025 See you next time!🗻⛷️🚠🧬🧫🧪💙

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Nature Communications @natcomms.nature.com · 17/02/2025

Structural biology: #Mycobacteria use molecules called mycobactins to capture iron, then taken up by a membrane transporter Gonda et al. show that mycobactin slides down a crevice at the transporter surface & goes across the membrane in a “credit card” mechanism 🦠🧪 www.nature.com/articles/s41...

Proposed mechanism for import and reduction of mycobactin by IrtAB

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ABC2025 @abcmeeting.bsky.social · 02/03/2025

Markus from @seegerlab.bsky.social wakes us up with a fresh take on metal metabolism in Mycobacteria... So you think you have an exporter on your hands? Make sure it doesn't import instead - no iron(y) 😁

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Seeger Lab @seegerlab.bsky.social · 30/01/2023

Here you'll find everything a structure-function aficionado might hope for: ✅ Crystallography 💎 ✅ Cryo-EM 🔬 ✅ Nanobodies 🦙 ✅ Mutational analysis 🧬 ✅ Molecular dynamics simulations 🖥️

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Seeger Lab @seegerlab.bsky.social · 14/12/2022

Congrats to Dr. Sille Remm for winning the 1st special prize from the President of Estonian Academy of Science "for the most elegant work" in the Estonian National Student Science Competition!🥳👏 So proud of you!

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Seeger Lab @seegerlab.bsky.social · 28/11/2022

Many thanks to our collaborators @Barandunlab, @kai_ehrenbolger for their great effort to determine the cryoEM structure of EfrCD💪💪☺️

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Seeger Lab @seegerlab.bsky.social · 28/11/2022

Proud to see our DMS paper out in @nchembio after going through a productive review process🥳EfrCD's drug efflux activity profile determined for >1400 single variants. Identified single mutations that convert the exporter into a drug-specific ABC importer! nature.com/articles/s4158…

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Seeger Lab @seegerlab.bsky.social · 02/11/2022

For their project - IBD NanoBiotics - the team engineered gut microbiota member E. coli Nissle 1917 to secrete anti-inflammatory nanobodies which dampen inflammation in GI tract of IBD patients. Supervised by Kenny from @MartinJinek lab, Jenna and @f_ackle from our lab

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Seeger Lab @seegerlab.bsky.social · 02/11/2022

Congrats to the @uzh iGEM team for winning the best therapeutics project🥇 and best new basic part awards🥇 and for getting into the top 10 among the 350 projects at this year's @iGEM Jamboree in Paris! We're happy for all your achievements! 🤩👏It was fun to host you in our lab!

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Seeger Lab @seegerlab.bsky.social · 28/10/2022

new group photo... PARKOUR!🤸🏻‍♀️💨

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Seeger Lab @seegerlab.bsky.social · 13/10/2022

😍😍 x.com/krparey/status…

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Seeger Lab @seegerlab.bsky.social · 12/10/2022

The climax of a 5 year collaborative project with the @enricabordignon lab: spin-labelled nanobodies to probe the conformational space of MsbA in intact cells published in @ScienceAdvances. Structures by @MoellerGroup and MD simulations by Lars Schäfer lab science.org/doi/10.1126/sc…

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Seeger Lab @seegerlab.bsky.social · 13/09/2022

Congrats to Sille Remm for successfully defending her PhD thesis!🥳👩‍🎓 You did very well biting through this tough project! We're so proud of you!☺️☺️

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Seeger Lab @seegerlab.bsky.social · 16/08/2022

The temperature dropped by a few degrees yesterday, so we decided to have a raclette on our rooftop🧀😋

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Seeger Lab @seegerlab.bsky.social · 09/06/2022

Congrats to everyone! We are super proud of you, Imre 🤩💪@Prolatium x.com/ITTS_Cure/stat…

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Seeger Lab @seegerlab.bsky.social · 05/06/2022

Four weeks of time flied so fast! We're happy that you enjoyed your stay and we had a great time with you too. Many thanks for all the scientific discussions and after work beers🍻😉. We're excited to see the sybody selection platform being implemented in the @Intein lab🥳 t.co/x5vKO8BMQu

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Seeger Lab @seegerlab.bsky.social · 27/04/2022

...and here are the heros of the review, Michèle Sorgenfrei and Lea Huber-Hürlimann. The PI is very proud!!

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Seeger Lab @seegerlab.bsky.social · 27/04/2022

We're happy to announce that our latest review about biomolecules capturing live bacteria from clinical samples is out on @TrendsBiochem !!🥳🥳 doi.org/10.1016/j.tibs…

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Seeger Lab @seegerlab.bsky.social · 08/04/2022

How many memes does it take for people to clean up?

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Seeger Lab @seegerlab.bsky.social · 08/04/2022

4 unsuccessful attempts in form of memes to encourage people to clean their mess😅😅 #TGIF

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Seeger Lab @seegerlab.bsky.social · 16/03/2022

On a special mission to join a delegation of the Round Table Antibiotics to talk with members of the Swiss parliament about the urgent need to increase the federal budget to fight #AMR 💊🦠

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Seeger Lab @seegerlab.bsky.social · 07/03/2022

📢Our rapid response to the COVID-19 pandemic finally in peer-reviewed form @emboreports in collaboration with Philippe Plattet, @CPaulino_ @MembraneEnzymo1 🥳 „Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance“ doi.org/10.15252/embr.…

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Seeger Lab @seegerlab.bsky.social · 27/01/2022

Preparing E.coli produced avocado smoothie🥑 for the afternoon apéro... or is it GFP-tagged protein?😜

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Seeger Lab @seegerlab.bsky.social · 16/12/2021

We know it😅 thanks for measuring the samples! x.com/enricabordigno…

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Seeger Lab @seegerlab.bsky.social · 20/10/2021

The heros of this review, Sille Remm and Jennifer Earp, with a very proud PI

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Seeger Lab @seegerlab.bsky.social · 20/10/2021

We're excited that our latest review on the multifaceted characters of mycobacterial drug efflux pumps is out in @FEMSmicro 🥳🥳 Great collaboration with @ThomasD57648102 and @vdartois1🤝#mycobacteria #tuberculosis #drugefflux doi.org/10.1093/femsre…

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Seeger Lab @seegerlab.bsky.social · 02/10/2021

The cryoEM structure was solved by @kai_ehrenbolger and @Barandunlab in Umeå (@mims_umea). Many thanks for the great collaboration!

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Seeger Lab @seegerlab.bsky.social · 02/10/2021

Our latest preprint is out🥳We performed DMS on EfrCD to determine the drug efflux activity profile of 1539 single variants! Many interesting findings🔎, amongst which, that single mutations (!) can convert the exporter into a drug-specific ABC importer! doi.org/10.1101/2021.1…

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Seeger Lab @seegerlab.bsky.social · 22/09/2021

Thanks for the great organization!! Looking forward to the 3rd edition in Paris, 2023!!🦙 x.com/VIBLifeScience…

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Seeger Lab @seegerlab.bsky.social · 16/09/2021

Congrats to @CamiloPerez_BZ and team!🔥👏 We're happy to have contributed to the success of this great work! Once again #sybodies enabled the structure determination of a small membrane protein. t.co/9brN71a2pp biorxiv.org/content/10.110…

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Seeger Lab @seegerlab.bsky.social · 14/09/2021

Congrats to @DenekaDawid, Sonja Rutz and @MartaSawicka6 from the Dutzler lab for this fantastic piece of work!🥳👏 Great to see that sybodies helped to shed light on the mechanism of volume-regulated channels! nature.com/articles/s4146…

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Seeger Lab @seegerlab.bsky.social · 10/09/2021

Congrats to Michèle for winning the Poster prize at the #Nanobodies21 conference! The PI is proud of you😁🥳

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Seeger Lab @seegerlab.bsky.social · 09/09/2021

Hope all the in-person and virtual attendees of the #Nanobodies21 conference have enjoyed Justin Walter‘s talk about the Nestlink Technology 😁🍰 Justin, you made us proud!

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Seeger Lab @seegerlab.bsky.social · 09/09/2021

She‘s in good hands!😁 x.com/ChromoTekGmbH/…

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Seeger Lab @seegerlab.bsky.social · 08/09/2021

On our way to the #nanobodies21 conference in Brussels 🇧🇪🦙

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Seeger Lab @seegerlab.bsky.social · 29/06/2021

📢Don't miss it: Markus is giving a talk at the @EMBO workshop titled "Recent Advances in Structural Biology of Membrane Proteins" #EMBOMPsRegistration deadline is the 1st of November! embl.org/about/info/cou…

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Seeger Lab @seegerlab.bsky.social · 28/06/2021

The Seeger lab is fully vaccinated💉 We did an antibody test 2 weeks after the 2nd shot and…nice response💪🏽😄 Fun fact: a bispecific fusion of our sybody pair is coated on the control lane!

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Seeger Lab @seegerlab.bsky.social · 17/06/2021

Congrats Gianluca and @MembraneEnzymo1 for this amazing work!👏👏 Using a conformation-specific #sybody that inactivates the aspartate transporter, they could perform reliable uptake assays in proteoliposomes and shed light on the kinetic mechanism of the transporter! x.com/MembraneEnzymo…

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Seeger Lab @seegerlab.bsky.social · 14/06/2021

Here it is - the new logo of the lab!😀

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Seeger Lab @seegerlab.bsky.social · 27/05/2021

🎓🧑‍🎓Congrats to Gianmarco for successfully defending his PhD thesis! Great achievements over the last years!💪💪 We're very proud of him!🥳

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Seeger Lab @seegerlab.bsky.social · 05/02/2021

Agonist-bound OX2R cryo-EM structure in complex with a conformation-specific sybody👏We are proud to have contributed to this seminal study of Kaspar Hollenstein from @Merck by generating a conformation-selective high-affinity (600 pM) sybody💪 nature.com/articles/s4146…

nature.com

Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation

Nature Communications - Agonists of the orexin receptor 2 (OX2R) show promise in the treatment of narcolepsy. Cryo-EM structures of active-state OX2R bound to an endogenous peptide agonist and a...

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