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Seeger Lab

@seegerlab.bsky.social
126 followers 106 following 83 posts

Lab of Prof. Markus A. Seeger, @UZH_en, posts by group members; great admirers of membrane proteins, nanobodies, sybodies, structural biology and microbiology

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Seeger Lab @seegerlab.bsky.social · 21/04/2026
Congrats to Fabian Ackle (@fabianackle.ch) for successfully defending his PhD thesis! 🥳👩‍🎓 You did an excellent job setting up and driving this project forward! We’ve always admired your curiosity and passion for science! We’re so proud of you! ☺️
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Stephan Gruber @gruberlab.bsky.social · 20/10/2025
This was a fun collaboration between Ophélie & the @seegerlab.bsky.social using sybody libraries to target the SMC complex in living bacteria. With a suprising finding: the 14 isolated sybodies bind to the middle of the SMC coiled coil rather than the more conserved ATPase heads.
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Nature Methods @natmethods.nature.com · 29/08/2025
A laser flash melting procedure, followed by rapid revitrification, provides a simple approach to help mitigate the preferred orientation problem that plagues cryo-EM analysis. www.nature.com/articles/s41...
nature.com
Laser flash melting cryo-EM samples to overcome preferred orientation - Nature Methods
Individual proteins tend to adopt preferred orientations when subjected to vitrification for cryo-electron microscopy analysis. A laser flash melting procedure followed by rapid revitrification provid...
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Camilo Perez @camiloperezc6h6.bsky.social · 21/08/2025
We are hiring a Postdoc in membrane protein cryo-EM at the University of Georgia. Looking for candidates with expertise in membrane protein purification and biochemistry. Fully funded for up to 5 years. Join us in Athens, GA. Apply: camilo.perez@uga.edu
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Carolyn King @immunologyking.bsky.social · 20/08/2025
always a pleasure discussing all things #tuberculosis with this group @seegerlab.bsky.social @berndwollscheid.bsky.social & Michael Berney
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Arne Möller @arnemoeller.bsky.social · 28/04/2025
Dear all, I am very excited about the upcoming 842 WE-Heraeus-Seminar #Cryo-EM on the Move. @djanuliene.bsky.social and I are looking forward to a great conference with many exciting speakers!
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ABC2025 @abcmeeting.bsky.social · 07/03/2025
We had an amazing time with the ABC family and already miss you all! Can’t wait to hear your exciting talks, have great discussions, and hit the slopes of the Alps again. #ABC2025 See you next time!🗻⛷️🚠🧬🧫🧪💙
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Nature Communications @natcomms.nature.com · 17/02/2025
Structural biology: #Mycobacteria use molecules called mycobactins to capture iron, then taken up by a membrane transporter Gonda et al. show that mycobactin slides down a crevice at the transporter surface & goes across the membrane in a “credit card” mechanism 🦠🧪 www.nature.com/articles/s41...
Proposed mechanism for import and reduction of mycobactin by IrtAB
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ABC2025 @abcmeeting.bsky.social · 02/03/2025
Markus from @seegerlab.bsky.social wakes us up with a fresh take on metal metabolism in Mycobacteria... So you think you have an exporter on your hands? Make sure it doesn't import instead - no iron(y) 😁
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Seeger Lab @seegerlab.bsky.social · 14/12/2022
Congrats to Dr. Sille Remm for winning the 1st special prize from the President of Estonian Academy of Science "for the most elegant work" in the Estonian National Student Science Competition!🥳👏 So proud of you!
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Seeger Lab @seegerlab.bsky.social · 28/11/2022
Proud to see our DMS paper out in @nchembio after going through a productive review process🥳EfrCD's drug efflux activity profile determined for >1400 single variants. Identified single mutations that convert the exporter into a drug-specific ABC importer! nature.com/articles/s4158…
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Seeger Lab @seegerlab.bsky.social · 02/11/2022
Congrats to the @uzh iGEM team for winning the best therapeutics project🥇 and best new basic part awards🥇 and for getting into the top 10 among the 350 projects at this year's @iGEM Jamboree in Paris! We're happy for all your achievements! 🤩👏It was fun to host you in our lab!
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Seeger Lab @seegerlab.bsky.social · 28/10/2022
new group photo... PARKOUR!🤸🏻‍♀️💨
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Seeger Lab @seegerlab.bsky.social · 13/10/2022
😍😍 x.com/krparey/status…
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Seeger Lab @seegerlab.bsky.social · 12/10/2022
The climax of a 5 year collaborative project with the @enricabordignon lab: spin-labelled nanobodies to probe the conformational space of MsbA in intact cells published in @ScienceAdvances. Structures by @MoellerGroup and MD simulations by Lars Schäfer lab science.org/doi/10.1126/sc…
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Seeger Lab @seegerlab.bsky.social · 13/09/2022
Congrats to Sille Remm for successfully defending her PhD thesis!🥳👩‍🎓 You did very well biting through this tough project! We're so proud of you!☺️☺️
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Seeger Lab @seegerlab.bsky.social · 16/08/2022
The temperature dropped by a few degrees yesterday, so we decided to have a raclette on our rooftop🧀😋
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Seeger Lab @seegerlab.bsky.social · 09/06/2022
Congrats to everyone! We are super proud of you, Imre 🤩💪@Prolatium x.com/ITTS_Cure/stat…
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Seeger Lab @seegerlab.bsky.social · 05/06/2022
Four weeks of time flied so fast! We're happy that you enjoyed your stay and we had a great time with you too. Many thanks for all the scientific discussions and after work beers🍻😉. We're excited to see the sybody selection platform being implemented in the @Intein lab🥳 t.co/x5vKO8BMQu
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Seeger Lab @seegerlab.bsky.social · 27/04/2022
We're happy to announce that our latest review about biomolecules capturing live bacteria from clinical samples is out on @TrendsBiochem !!🥳🥳 doi.org/10.1016/j.tibs…
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Seeger Lab @seegerlab.bsky.social · 08/04/2022
4 unsuccessful attempts in form of memes to encourage people to clean their mess😅😅 #TGIF
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Seeger Lab @seegerlab.bsky.social · 16/03/2022
On a special mission to join a delegation of the Round Table Antibiotics to talk with members of the Swiss parliament about the urgent need to increase the federal budget to fight #AMR 💊🦠
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Seeger Lab @seegerlab.bsky.social · 07/03/2022
📢Our rapid response to the COVID-19 pandemic finally in peer-reviewed form @emboreports in collaboration with Philippe Plattet, @CPaulino_ @MembraneEnzymo1 🥳 „Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance“ doi.org/10.15252/embr.…
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Seeger Lab @seegerlab.bsky.social · 27/01/2022
Preparing E.coli produced avocado smoothie🥑 for the afternoon apéro... or is it GFP-tagged protein?😜
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Seeger Lab @seegerlab.bsky.social · 16/12/2021
We know it😅 thanks for measuring the samples! x.com/enricabordigno…
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Seeger Lab @seegerlab.bsky.social · 20/10/2021
We're excited that our latest review on the multifaceted characters of mycobacterial drug efflux pumps is out in @FEMSmicro 🥳🥳 Great collaboration with @ThomasD57648102 and @vdartois1🤝#mycobacteria #tuberculosis #drugefflux doi.org/10.1093/femsre…
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Seeger Lab @seegerlab.bsky.social · 02/10/2021
Our latest preprint is out🥳We performed DMS on EfrCD to determine the drug efflux activity profile of 1539 single variants! Many interesting findings🔎, amongst which, that single mutations (!) can convert the exporter into a drug-specific ABC importer! doi.org/10.1101/2021.1…
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Seeger Lab @seegerlab.bsky.social · 22/09/2021
Thanks for the great organization!! Looking forward to the 3rd edition in Paris, 2023!!🦙 x.com/VIBLifeScience…
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Seeger Lab @seegerlab.bsky.social · 16/09/2021
Congrats to @CamiloPerez_BZ and team!🔥👏 We're happy to have contributed to the success of this great work! Once again #sybodies enabled the structure determination of a small membrane protein. t.co/9brN71a2pp biorxiv.org/content/10.110…
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Seeger Lab @seegerlab.bsky.social · 14/09/2021
Congrats to @DenekaDawid, Sonja Rutz and @MartaSawicka6 from the Dutzler lab for this fantastic piece of work!🥳👏 Great to see that sybodies helped to shed light on the mechanism of volume-regulated channels! nature.com/articles/s4146…
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Seeger Lab @seegerlab.bsky.social · 10/09/2021
Congrats to Michèle for winning the Poster prize at the #Nanobodies21 conference! The PI is proud of you😁🥳
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Seeger Lab @seegerlab.bsky.social · 09/09/2021
Hope all the in-person and virtual attendees of the #Nanobodies21 conference have enjoyed Justin Walter‘s talk about the Nestlink Technology 😁🍰 Justin, you made us proud!
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Seeger Lab @seegerlab.bsky.social · 09/09/2021
She‘s in good hands!😁 x.com/ChromoTekGmbH/…
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Seeger Lab @seegerlab.bsky.social · 08/09/2021
On our way to the #nanobodies21 conference in Brussels 🇧🇪🦙
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Seeger Lab @seegerlab.bsky.social · 29/06/2021
📢Don't miss it: Markus is giving a talk at the @EMBO workshop titled "Recent Advances in Structural Biology of Membrane Proteins" #EMBOMPsRegistration deadline is the 1st of November! embl.org/about/info/cou…
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Seeger Lab @seegerlab.bsky.social · 28/06/2021
The Seeger lab is fully vaccinated💉 We did an antibody test 2 weeks after the 2nd shot and…nice response💪🏽😄 Fun fact: a bispecific fusion of our sybody pair is coated on the control lane!
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Seeger Lab @seegerlab.bsky.social · 17/06/2021
Congrats Gianluca and @MembraneEnzymo1 for this amazing work!👏👏 Using a conformation-specific #sybody that inactivates the aspartate transporter, they could perform reliable uptake assays in proteoliposomes and shed light on the kinetic mechanism of the transporter! x.com/MembraneEnzymo…
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Seeger Lab @seegerlab.bsky.social · 14/06/2021
Here it is - the new logo of the lab!😀
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Seeger Lab @seegerlab.bsky.social · 14/06/2021
We're excited to launch our new websiteCheck it out to get to know more about our lab's research projects and enjoy the pictures under "social"😃 seegerlab.org
seegerlab.org
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RESEARCH GROUP SEEGER university of zurich RESEARCH GROUP SEEGER university of zurich RESEARCH GROUP SEEGER university of zurich RESEARCH GROUP SEEGER university of zurich RESEARCH GROUP SEEGER university of zurich RESEARCH GROUP SEEGER university of zurich RESEARCH GROUP SEEGER university of zurich RESEARCH GROUP SEEGER university of zurich our projects MycoTransport DrugEfflux Sybodies NestLink All … Home Read More »
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Seeger Lab @seegerlab.bsky.social · 27/05/2021
🎓🧑‍🎓Congrats to Gianmarco for successfully defending his PhD thesis! Great achievements over the last years!💪💪 We're very proud of him!🥳
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Seeger Lab @seegerlab.bsky.social · 05/02/2021
Agonist-bound OX2R cryo-EM structure in complex with a conformation-specific sybody👏We are proud to have contributed to this seminal study of Kaspar Hollenstein from @Merck by generating a conformation-selective high-affinity (600 pM) sybody💪 nature.com/articles/s4146…
nature.com
Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation
Nature Communications - Agonists of the orexin receptor 2 (OX2R) show promise in the treatment of narcolepsy. Cryo-EM structures of active-state OX2R bound to an endogenous peptide agonist and a...
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Seeger Lab @seegerlab.bsky.social · 20/01/2021
A beautiful start into the day! Sunrise view from our rooftop🌄☕️
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Seeger Lab @seegerlab.bsky.social · 15/12/2020
secure.avaaz.org/community_peti…
secure.avaaz.org
The next budget Horizon Europe (2021-27) will be vital to survive ! COVID-19 & Climate !
It is clear that Europe and our planet are currently exploded by two issues: COVID-19 and also Climate Change. And to survive, the scientific research is vital, as we saw on the recent active and innovative research knowledges on these two key issues, but which needs to continue to progress for the vital solutions. The problem has been the fact that the EU national leaders of the European Council mentioned last July a strong reduction of 13,5 billion euros of the budget already mentioned in previous May, for the next Horizon Europe which will start in 2021 until 2027.<br...
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Seeger Lab @seegerlab.bsky.social · 17/11/2020
An exciting project to watch: engineered phages to treat urinary tract infections. x.com/MartinLoessner…
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Seeger Lab @seegerlab.bsky.social · 01/10/2020
song credit: @parrygripp
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Seeger Lab @seegerlab.bsky.social · 21/09/2020
The Seeger Lab in 2020😀
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Seeger Lab @seegerlab.bsky.social · 24/08/2020
Many thanks! It was a pleasure to have @TaschnerMichael in Zurich to perform selections with us😄 Let‘s hope that they are conformation-specific binders! Fingers crossed🤞🏾 t.co/uGTeTo9fiX
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Seeger Lab @seegerlab.bsky.social · 18/06/2020
Your own #sybodies selected within 3 weeks! The sybody generation toolbox is available on @Addgene. Also, check out their blog about our selection process! x.com/Addgene/status…
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Seeger Lab @seegerlab.bsky.social · 04/06/2020
„Protect the European Council (ERC) in the EU budget” - Jetzt unterschreiben!via @Change chng.it/Xwj4yXxX
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